Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

Publications

Peer reviewed articles (10)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

Author(s): Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin
Published in: Chemistry – A European Journal, 27/11, 2021, Page(s) 3806-3811, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004694

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

Author(s): David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright
Published in: Journal of Biological Chemistry, 297/2, 2021, Page(s) 100918, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100918

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

Author(s): Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin
Published in: Journal of Medicinal Chemistry, 64/13, 2021, Page(s) 9141-9151, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00362

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**

Author(s): Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin
Published in: ChemMedChem, 16/10, 2021, Page(s) 1651-1659, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100042

β-lactam/β-lactamase inhibitor combinations: an update

Author(s): Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin
Published in: MedChemComm, 9/9, 2018, Page(s) 1439-1456, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8md00342d

A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens

Author(s): Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin
Published in: Journal of Medicinal Chemistry, 64/15, 2021, Page(s) 10890-10899, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00176

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

Author(s): Thomas M. Wood, Nathaniel I. Martin
Published in: MedChemComm, 10/5, 2019, Page(s) 634-646, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9md00126c

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

Author(s): Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin
Published in: Chemical Communications, 56/20, 2020, Page(s) 3047-3049, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc00356e

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

Author(s): Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Published in: ACS Infectious Diseases, 6/6, 2020, Page(s) 1366-1371, ISSN 2373-8227
Publisher: America Chemical Society
DOI: 10.1021/acsinfecdis.9b00459

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

Author(s): Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin
Published in: Organic & Biomolecular Chemistry, 18/3, 2020, Page(s) 514-517, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9ob02534k