Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

Project Information

NO-ESKAPE

Grant agreement ID: 725523

DOI 10.3030/725523

Project closed

EC signature date 30 May 2017

Start date 1 June 2017

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITEIT LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

Author(s): Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin
Published in: Chemistry – A European Journal, Issue 27/11, 2021, Page(s) 3806-3811, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004694

Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption

Author(s): Nathaniel Martin; Angeliki Ioli Kotsogianni Teftsoglou; Charlotte Wesseling; Cornelis Jacob Slingerland
Published in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00307

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

Author(s): David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright
Published in: Journal of Biological Chemistry, Issue 297/2, 2021, Page(s) 100918, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100918

Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine.

Author(s): Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Published in: RSC Medicinal Chemistry, 2022, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2md00281g

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Author(s): Karol Al Ayed; Ross D. Ballantine; Michael Hoekstra; Samantha J. Bann; Charlotte M. J. Wesseling; Alexander T. Bakker; Zheng Zhong; Yong-Xin Li; Nora C. Brüchle; Mario van der Stelt; Stephen A. Cochrane; Nathaniel I. Martin
Published in: Chemical Science, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc00143h

Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity

Author(s): Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Published in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00308

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.

Author(s): Charlotte M J Wesseling; Cornelis J Slingerland; Shanice Veraar; Samantha Lok; Nathaniel I. Martin
Published in: ACS Infectious Diseases, 2021, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00466

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

Author(s): Ioli Kotsogianni; Thomas M. Wood; Francesca M. Alexander; Stephen A. Cochrane; Nathaniel I. Martin
Published in: ACS Infectious Diseases, 2021, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00316

Vancomycin-Polymyxin Nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains

Author(s): Groesen, Emma van; Slingerland, Cornelis J.; Innocenti, Paolo; Mihajlovic, Milos; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Published in: ACS Infectious Diseases, 2021, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00318

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022

Author(s): Emma van Groesen; Paolo Innocenti; Nathaniel I. Martin
Published in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00253

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Author(s): Bakker, A.T.; Kotsogianni, A.I.; Mirenda, L.; Straub, V.M.; Avalos Garcia, M.; Berg, R.J.B.H.N. van den; Florea, B.I.; Wezel, G.P. van; Janssen, A.P.A.; Martin, N.I.; Stelt, M. van der
Published in: Journal of the American Chemical Society, 2023, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c10819

opening the door for gram-positive specific antibiotics

Author(s): Nathaniel Martin; Charlotte Wesseling
Published in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00193

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

Author(s): Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin
Published in: Journal of Medicinal Chemistry, Issue 64/13, 2021, Page(s) 9141-9151, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00362

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Author(s): Ali Javed; Cornelis J. Slingerland; Thomas M. Wood; Nathaniel I. Martin; Femke Broere; Markus H. Weingarth; Edwin J. A. Veldhuizen
Published in: ACS Infectious Diseases, 2023, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00518

Metabolic labeling probes for interrogation of the host–pathogen interaction

Author(s): Bob J Ignacio; Thomas Bakkum; Kimberly M. Bonger; Nathaniel I. Martin; Sander I. van Kasteren
Published in: Organic & Biomolecular Chemistry, 2021, ISSN 1477-0539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ob02517h

Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria.

Author(s): Charlotte M J Wesseling; Thomas M. Wood; Thomas M. Wood; Kristine Bertheussen; Samantha Lok; Nathaniel I. Martin
Published in: Molecules, 2021, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26071954

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**

Author(s): Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin
Published in: ChemMedChem, Issue 16/10, 2021, Page(s) 1651-1659, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100042

Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494.

Author(s): Nicola Wade; Charlotte M. J. Wesseling; Paolo Innocenti; Cornelis J. Slingerland; Gregory M. Koningstein; Joen Luirink; Nathaniel I. Martin
Published in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00459

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures

Author(s): Wood, Thomas M.; Zeronian, Matthieu R.; Buijs, Ned; Bertheussen, Kristine; Abedian, Hanieh K.; Johnson, Aidan V.; Pearce, Nicholas M.; Lutz, Martin; Kemmink, Johan; Seirsma, Tjalling; Hamoen, Leendert W.; Janssen, Bert J. C.; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Sub Structural Biochemistry; Structural Biochemistry; Pharmacology
Published in: Chemical Science, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc07190d

β-lactam/β-lactamase inhibitor combinations: an update

Author(s): Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin
Published in: MedChemComm, Issue 9/9, 2018, Page(s) 1439-1456, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8md00342d

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Author(s): Karol Al Ayed; Denise Zamarbide Losada; Nataliia V. Machushynets; Barbara Terlouw; Somayah S. Elsayed; Julian Schill; Vincent Trebosc; Michel Pieren; Marnix H. Medema; Gilles P. van Wezel; Nathaniel I. Martin
Published in: ACS Infectious Diseases, 2023, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.3c00043

A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens

Author(s): Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin
Published in: Journal of Medicinal Chemistry, Issue 64/15, 2021, Page(s) 10890-10899, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00176

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Author(s): Ned Buijs, Halana C. Vlaming, Matthijs J. van Haren, Nathaniel I. Martin
Published in: ChemBioChem, 2022, ISSN 1439-7633
Publisher: Wiley
DOI: 10.1002/cbic.202200547

Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids

Author(s): Slingerland, Cornelis J.; Wesseling, Charlotte M. J.; Innocenti, Paolo; Westphal, Koen G. C.; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Published in: Journal of Medicinal Chemistry, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01528

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

Author(s): Thomas M. Wood, Nathaniel I. Martin
Published in: MedChemComm, Issue 10/5, 2019, Page(s) 634-646, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9md00126c

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

Author(s): Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin
Published in: Chemical Communications, Issue 56/20, 2020, Page(s) 3047-3049, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc00356e

Dual targeting of the class V lanthipeptide antibiotic cacaoidin

Author(s): Julia P. Deisinger; Melina Arts; Ioli Kotsogianni; Jan-Samuel Puls; Fabian Grein; Francisco Javier Ortiz-López; Nathaniel I. Martin; Anna Müller; Olga Genilloud; Tanja Schneider
Published in: iScience, 2023, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2023.106394

A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation

Author(s): Liubov Yakovlieva; Thomas M. Wood; Thomas M. Wood; Johan Kemmink; Ioli Kotsogianni; Franziska Koller; Juergen Lassak; Nathaniel I. Martin; Marthe T. C. Walvoort
Published in: Chemical Science, 2021, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05823h

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

Author(s): Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Published in: ACS Infectious Diseases, Issue 6/6, 2020, Page(s) 1366-1371, ISSN 2373-8227
Publisher: America Chemical Society
DOI: 10.1021/acsinfecdis.9b00459

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

Author(s): Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin
Published in: Organic & Biomolecular Chemistry, Issue 18/3, 2020, Page(s) 514-517, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9ob02534k