Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

Informations projet

NO-ESKAPE

N° de convention de subvention: 725523

DOI

10.3030/725523

Projet clôturé

Date de signature de la CE 30 Mai 2017

Date de début 1 Juin 2017

Date de fin 31 Mai 2023

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 000 000,00

Contribution de l’UE

€ 2 000 000,00

Coordonné par

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Peer reviewed articles (30)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

Auteurs: Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin
Publié dans: Chemistry – A European Journal, Numéro 27/11, 2021, Page(s) 3806-3811, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004694

Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption

Auteurs: Nathaniel Martin; Angeliki Ioli Kotsogianni Teftsoglou; Charlotte Wesseling; Cornelis Jacob Slingerland
Publié dans: ACS Infectious Diseases, 2022, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00307

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

Auteurs: David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright
Publié dans: Journal of Biological Chemistry, Numéro 297/2, 2021, Page(s) 100918, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100918

Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine.

Auteurs: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Publié dans: RSC Medicinal Chemistry, 2022, ISSN 2632-8682
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2md00281g

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Auteurs: Karol Al Ayed; Ross D. Ballantine; Michael Hoekstra; Samantha J. Bann; Charlotte M. J. Wesseling; Alexander T. Bakker; Zheng Zhong; Yong-Xin Li; Nora C. Brüchle; Mario van der Stelt; Stephen A. Cochrane; Nathaniel I. Martin
Publié dans: Chemical Science, 2022, ISSN 2041-6539
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2sc00143h

Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity

Auteurs: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Publié dans: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00308

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.

Auteurs: Charlotte M J Wesseling; Cornelis J Slingerland; Shanice Veraar; Samantha Lok; Nathaniel I. Martin
Publié dans: ACS Infectious Diseases, 2021, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00466

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

Auteurs: Ioli Kotsogianni; Thomas M. Wood; Francesca M. Alexander; Stephen A. Cochrane; Nathaniel I. Martin
Publié dans: ACS Infectious Diseases, 2021, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00316

Vancomycin-Polymyxin Nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains

Auteurs: Groesen, Emma van; Slingerland, Cornelis J.; Innocenti, Paolo; Mihajlovic, Milos; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Publié dans: ACS Infectious Diseases, 2021, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00318

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022

Auteurs: Emma van Groesen; Paolo Innocenti; Nathaniel I. Martin
Publié dans: ACS Infectious Diseases, 2022, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00253

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Auteurs: Bakker, A.T.; Kotsogianni, A.I.; Mirenda, L.; Straub, V.M.; Avalos Garcia, M.; Berg, R.J.B.H.N. van den; Florea, B.I.; Wezel, G.P. van; Janssen, A.P.A.; Martin, N.I.; Stelt, M. van der
Publié dans: Journal of the American Chemical Society, 2023, ISSN 1520-5126
Éditeur: American Chemical Society
DOI: 10.1021/jacs.2c10819

opening the door for gram-positive specific antibiotics

Auteurs: Nathaniel Martin; Charlotte Wesseling
Publié dans: ACS Infectious Diseases, 2022, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00193

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

Auteurs: Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin
Publié dans: Journal of Medicinal Chemistry, Numéro 64/13, 2021, Page(s) 9141-9151, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00362

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Auteurs: Ali Javed; Cornelis J. Slingerland; Thomas M. Wood; Nathaniel I. Martin; Femke Broere; Markus H. Weingarth; Edwin J. A. Veldhuizen
Publié dans: ACS Infectious Diseases, 2023, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00518

Metabolic labeling probes for interrogation of the host–pathogen interaction

Auteurs: Bob J Ignacio; Thomas Bakkum; Kimberly M. Bonger; Nathaniel I. Martin; Sander I. van Kasteren
Publié dans: Organic & Biomolecular Chemistry, 2021, ISSN 1477-0539
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0ob02517h

Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria.

Auteurs: Charlotte M J Wesseling; Thomas M. Wood; Thomas M. Wood; Kristine Bertheussen; Samantha Lok; Nathaniel I. Martin
Publié dans: Molecules, 2021, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26071954

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**

Auteurs: Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin
Publié dans: ChemMedChem, Numéro 16/10, 2021, Page(s) 1651-1659, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100042

Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494.

Auteurs: Nicola Wade; Charlotte M. J. Wesseling; Paolo Innocenti; Cornelis J. Slingerland; Gregory M. Koningstein; Joen Luirink; Nathaniel I. Martin
Publié dans: ACS Infectious Diseases, 2022, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00459

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures

Auteurs: Wood, Thomas M.; Zeronian, Matthieu R.; Buijs, Ned; Bertheussen, Kristine; Abedian, Hanieh K.; Johnson, Aidan V.; Pearce, Nicholas M.; Lutz, Martin; Kemmink, Johan; Seirsma, Tjalling; Hamoen, Leendert W.; Janssen, Bert J. C.; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Sub Structural Biochemistry; Structural Biochemistry; Pharmacology
Publié dans: Chemical Science, 2022, ISSN 2041-6539
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1sc07190d

β-lactam/β-lactamase inhibitor combinations: an update

Auteurs: Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin
Publié dans: MedChemComm, Numéro 9/9, 2018, Page(s) 1439-1456, ISSN 2040-2503
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8md00342d

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Auteurs: Karol Al Ayed; Denise Zamarbide Losada; Nataliia V. Machushynets; Barbara Terlouw; Somayah S. Elsayed; Julian Schill; Vincent Trebosc; Michel Pieren; Marnix H. Medema; Gilles P. van Wezel; Nathaniel I. Martin
Publié dans: ACS Infectious Diseases, 2023, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.3c00043

A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens

Auteurs: Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin
Publié dans: Journal of Medicinal Chemistry, Numéro 64/15, 2021, Page(s) 10890-10899, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00176

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Auteurs: Ned Buijs, Halana C. Vlaming, Matthijs J. van Haren, Nathaniel I. Martin
Publié dans: ChemBioChem, 2022, ISSN 1439-7633
Éditeur: Wiley
DOI: 10.1002/cbic.202200547

Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids

Auteurs: Slingerland, Cornelis J.; Wesseling, Charlotte M. J.; Innocenti, Paolo; Westphal, Koen G. C.; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Publié dans: Journal of Medicinal Chemistry, 2022, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01528

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

Auteurs: Thomas M. Wood, Nathaniel I. Martin
Publié dans: MedChemComm, Numéro 10/5, 2019, Page(s) 634-646, ISSN 2040-2503
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9md00126c

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

Auteurs: Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin
Publié dans: Chemical Communications, Numéro 56/20, 2020, Page(s) 3047-3049, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0cc00356e

Dual targeting of the class V lanthipeptide antibiotic cacaoidin

Auteurs: Julia P. Deisinger; Melina Arts; Ioli Kotsogianni; Jan-Samuel Puls; Fabian Grein; Francisco Javier Ortiz-López; Nathaniel I. Martin; Anna Müller; Olga Genilloud; Tanja Schneider
Publié dans: iScience, 2023, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2023.106394

A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation

Auteurs: Liubov Yakovlieva; Thomas M. Wood; Thomas M. Wood; Johan Kemmink; Ioli Kotsogianni; Franziska Koller; Juergen Lassak; Nathaniel I. Martin; Marthe T. C. Walvoort
Publié dans: Chemical Science, 2021, ISSN 2041-6539
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0sc05823h

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

Auteurs: Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Publié dans: ACS Infectious Diseases, Numéro 6/6, 2020, Page(s) 1366-1371, ISSN 2373-8227
Éditeur: America Chemical Society
DOI: 10.1021/acsinfecdis.9b00459

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

Auteurs: Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin
Publié dans: Organic & Biomolecular Chemistry, Numéro 18/3, 2020, Page(s) 514-517, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9ob02534k