Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

Informacje na temat projektu

NO-ESKAPE

Identyfikator umowy o grant: 725523

DOI

10.3030/725523

Projekt został zamknięty

Data podpisania przez KE 30 Maja 2017

Data rozpoczęcia 1 Czerwca 2017

Data zakończenia 31 Maja 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 000 000,00

Wkład UE

€ 2 000 000,00

Koordynowany przez

UNIVERSITEIT LEIDEN
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (30)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

Autorzy: Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin
Opublikowane w: Chemistry – A European Journal, Numer 27/11, 2021, Strona(/y) 3806-3811, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004694

Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption

Autorzy: Nathaniel Martin; Angeliki Ioli Kotsogianni Teftsoglou; Charlotte Wesseling; Cornelis Jacob Slingerland
Opublikowane w: ACS Infectious Diseases, 2022, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00307

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

Autorzy: David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright
Opublikowane w: Journal of Biological Chemistry, Numer 297/2, 2021, Strona(/y) 100918, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100918

Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine.

Autorzy: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Opublikowane w: RSC Medicinal Chemistry, 2022, ISSN 2632-8682
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2md00281g

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Autorzy: Karol Al Ayed; Ross D. Ballantine; Michael Hoekstra; Samantha J. Bann; Charlotte M. J. Wesseling; Alexander T. Bakker; Zheng Zhong; Yong-Xin Li; Nora C. Brüchle; Mario van der Stelt; Stephen A. Cochrane; Nathaniel I. Martin
Opublikowane w: Chemical Science, 2022, ISSN 2041-6539
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2sc00143h

Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity

Autorzy: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Opublikowane w: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00308

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.

Autorzy: Charlotte M J Wesseling; Cornelis J Slingerland; Shanice Veraar; Samantha Lok; Nathaniel I. Martin
Opublikowane w: ACS Infectious Diseases, 2021, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00466

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

Autorzy: Ioli Kotsogianni; Thomas M. Wood; Francesca M. Alexander; Stephen A. Cochrane; Nathaniel I. Martin
Opublikowane w: ACS Infectious Diseases, 2021, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00316

Vancomycin-Polymyxin Nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains

Autorzy: Groesen, Emma van; Slingerland, Cornelis J.; Innocenti, Paolo; Mihajlovic, Milos; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Opublikowane w: ACS Infectious Diseases, 2021, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00318

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022

Autorzy: Emma van Groesen; Paolo Innocenti; Nathaniel I. Martin
Opublikowane w: ACS Infectious Diseases, 2022, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00253

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Autorzy: Bakker, A.T.; Kotsogianni, A.I.; Mirenda, L.; Straub, V.M.; Avalos Garcia, M.; Berg, R.J.B.H.N. van den; Florea, B.I.; Wezel, G.P. van; Janssen, A.P.A.; Martin, N.I.; Stelt, M. van der
Opublikowane w: Journal of the American Chemical Society, 2023, ISSN 1520-5126
Wydawca: American Chemical Society
DOI: 10.1021/jacs.2c10819

opening the door for gram-positive specific antibiotics

Autorzy: Nathaniel Martin; Charlotte Wesseling
Opublikowane w: ACS Infectious Diseases, 2022, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00193

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

Autorzy: Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin
Opublikowane w: Journal of Medicinal Chemistry, Numer 64/13, 2021, Strona(/y) 9141-9151, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00362

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Autorzy: Ali Javed; Cornelis J. Slingerland; Thomas M. Wood; Nathaniel I. Martin; Femke Broere; Markus H. Weingarth; Edwin J. A. Veldhuizen
Opublikowane w: ACS Infectious Diseases, 2023, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00518

Metabolic labeling probes for interrogation of the host–pathogen interaction

Autorzy: Bob J Ignacio; Thomas Bakkum; Kimberly M. Bonger; Nathaniel I. Martin; Sander I. van Kasteren
Opublikowane w: Organic & Biomolecular Chemistry, 2021, ISSN 1477-0539
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0ob02517h

Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria.

Autorzy: Charlotte M J Wesseling; Thomas M. Wood; Thomas M. Wood; Kristine Bertheussen; Samantha Lok; Nathaniel I. Martin
Opublikowane w: Molecules, 2021, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26071954

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**

Autorzy: Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin
Opublikowane w: ChemMedChem, Numer 16/10, 2021, Strona(/y) 1651-1659, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100042

Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494.

Autorzy: Nicola Wade; Charlotte M. J. Wesseling; Paolo Innocenti; Cornelis J. Slingerland; Gregory M. Koningstein; Joen Luirink; Nathaniel I. Martin
Opublikowane w: ACS Infectious Diseases, 2022, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00459

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures

Autorzy: Wood, Thomas M.; Zeronian, Matthieu R.; Buijs, Ned; Bertheussen, Kristine; Abedian, Hanieh K.; Johnson, Aidan V.; Pearce, Nicholas M.; Lutz, Martin; Kemmink, Johan; Seirsma, Tjalling; Hamoen, Leendert W.; Janssen, Bert J. C.; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Sub Structural Biochemistry; Structural Biochemistry; Pharmacology
Opublikowane w: Chemical Science, 2022, ISSN 2041-6539
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1sc07190d

β-lactam/β-lactamase inhibitor combinations: an update

Autorzy: Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin
Opublikowane w: MedChemComm, Numer 9/9, 2018, Strona(/y) 1439-1456, ISSN 2040-2503
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c8md00342d

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Autorzy: Karol Al Ayed; Denise Zamarbide Losada; Nataliia V. Machushynets; Barbara Terlouw; Somayah S. Elsayed; Julian Schill; Vincent Trebosc; Michel Pieren; Marnix H. Medema; Gilles P. van Wezel; Nathaniel I. Martin
Opublikowane w: ACS Infectious Diseases, 2023, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.3c00043

A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens

Autorzy: Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin
Opublikowane w: Journal of Medicinal Chemistry, Numer 64/15, 2021, Strona(/y) 10890-10899, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00176

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Autorzy: Ned Buijs, Halana C. Vlaming, Matthijs J. van Haren, Nathaniel I. Martin
Opublikowane w: ChemBioChem, 2022, ISSN 1439-7633
Wydawca: Wiley
DOI: 10.1002/cbic.202200547

Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids

Autorzy: Slingerland, Cornelis J.; Wesseling, Charlotte M. J.; Innocenti, Paolo; Westphal, Koen G. C.; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Opublikowane w: Journal of Medicinal Chemistry, 2022, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01528

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

Autorzy: Thomas M. Wood, Nathaniel I. Martin
Opublikowane w: MedChemComm, Numer 10/5, 2019, Strona(/y) 634-646, ISSN 2040-2503
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9md00126c

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

Autorzy: Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin
Opublikowane w: Chemical Communications, Numer 56/20, 2020, Strona(/y) 3047-3049, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0cc00356e

Dual targeting of the class V lanthipeptide antibiotic cacaoidin

Autorzy: Julia P. Deisinger; Melina Arts; Ioli Kotsogianni; Jan-Samuel Puls; Fabian Grein; Francisco Javier Ortiz-López; Nathaniel I. Martin; Anna Müller; Olga Genilloud; Tanja Schneider
Opublikowane w: iScience, 2023, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/j.isci.2023.106394

A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation

Autorzy: Liubov Yakovlieva; Thomas M. Wood; Thomas M. Wood; Johan Kemmink; Ioli Kotsogianni; Franziska Koller; Juergen Lassak; Nathaniel I. Martin; Marthe T. C. Walvoort
Opublikowane w: Chemical Science, 2021, ISSN 2041-6539
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0sc05823h

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

Autorzy: Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Opublikowane w: ACS Infectious Diseases, Numer 6/6, 2020, Strona(/y) 1366-1371, ISSN 2373-8227
Wydawca: America Chemical Society
DOI: 10.1021/acsinfecdis.9b00459

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

Autorzy: Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin
Opublikowane w: Organic & Biomolecular Chemistry, Numer 18/3, 2020, Strona(/y) 514-517, ISSN 1477-0520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9ob02534k