Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

Información del proyecto

NO-ESKAPE

Identificador del acuerdo de subvención: 725523

DOI

10.3030/725523

Proyecto cerrado

Fecha de la firma de la CE 30 Mayo 2017

Fecha de inicio 1 Junio 2017

Fecha de finalización 31 Mayo 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 000 000,00

Aportación de la UE

€ 2 000 000,00

Coordinado por

UNIVERSITEIT LEIDEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (30)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

Autores: Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin
Publicado en: Chemistry – A European Journal, Edición 27/11, 2021, Página(s) 3806-3811, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004694

Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption

Autores: Nathaniel Martin; Angeliki Ioli Kotsogianni Teftsoglou; Charlotte Wesseling; Cornelis Jacob Slingerland
Publicado en: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00307

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

Autores: David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright
Publicado en: Journal of Biological Chemistry, Edición 297/2, 2021, Página(s) 100918, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100918

Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine.

Autores: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Publicado en: RSC Medicinal Chemistry, 2022, ISSN 2632-8682
Editor: Royal Society of Chemistry
DOI: 10.1039/d2md00281g

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Autores: Karol Al Ayed; Ross D. Ballantine; Michael Hoekstra; Samantha J. Bann; Charlotte M. J. Wesseling; Alexander T. Bakker; Zheng Zhong; Yong-Xin Li; Nora C. Brüchle; Mario van der Stelt; Stephen A. Cochrane; Nathaniel I. Martin
Publicado en: Chemical Science, 2022, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sc00143h

Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity

Autores: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Publicado en: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00308

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.

Autores: Charlotte M J Wesseling; Cornelis J Slingerland; Shanice Veraar; Samantha Lok; Nathaniel I. Martin
Publicado en: ACS Infectious Diseases, 2021, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00466

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

Autores: Ioli Kotsogianni; Thomas M. Wood; Francesca M. Alexander; Stephen A. Cochrane; Nathaniel I. Martin
Publicado en: ACS Infectious Diseases, 2021, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00316

Vancomycin-Polymyxin Nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains

Autores: Groesen, Emma van; Slingerland, Cornelis J.; Innocenti, Paolo; Mihajlovic, Milos; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Publicado en: ACS Infectious Diseases, 2021, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00318

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022

Autores: Emma van Groesen; Paolo Innocenti; Nathaniel I. Martin
Publicado en: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00253

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Autores: Bakker, A.T.; Kotsogianni, A.I.; Mirenda, L.; Straub, V.M.; Avalos Garcia, M.; Berg, R.J.B.H.N. van den; Florea, B.I.; Wezel, G.P. van; Janssen, A.P.A.; Martin, N.I.; Stelt, M. van der
Publicado en: Journal of the American Chemical Society, 2023, ISSN 1520-5126
Editor: American Chemical Society
DOI: 10.1021/jacs.2c10819

opening the door for gram-positive specific antibiotics

Autores: Nathaniel Martin; Charlotte Wesseling
Publicado en: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00193

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

Autores: Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin
Publicado en: Journal of Medicinal Chemistry, Edición 64/13, 2021, Página(s) 9141-9151, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00362

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Autores: Ali Javed; Cornelis J. Slingerland; Thomas M. Wood; Nathaniel I. Martin; Femke Broere; Markus H. Weingarth; Edwin J. A. Veldhuizen
Publicado en: ACS Infectious Diseases, 2023, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00518

Metabolic labeling probes for interrogation of the host–pathogen interaction

Autores: Bob J Ignacio; Thomas Bakkum; Kimberly M. Bonger; Nathaniel I. Martin; Sander I. van Kasteren
Publicado en: Organic & Biomolecular Chemistry, 2021, ISSN 1477-0539
Editor: Royal Society of Chemistry
DOI: 10.1039/d0ob02517h

Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria.

Autores: Charlotte M J Wesseling; Thomas M. Wood; Thomas M. Wood; Kristine Bertheussen; Samantha Lok; Nathaniel I. Martin
Publicado en: Molecules, 2021, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26071954

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**

Autores: Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin
Publicado en: ChemMedChem, Edición 16/10, 2021, Página(s) 1651-1659, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100042

Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494.

Autores: Nicola Wade; Charlotte M. J. Wesseling; Paolo Innocenti; Cornelis J. Slingerland; Gregory M. Koningstein; Joen Luirink; Nathaniel I. Martin
Publicado en: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00459

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures

Autores: Wood, Thomas M.; Zeronian, Matthieu R.; Buijs, Ned; Bertheussen, Kristine; Abedian, Hanieh K.; Johnson, Aidan V.; Pearce, Nicholas M.; Lutz, Martin; Kemmink, Johan; Seirsma, Tjalling; Hamoen, Leendert W.; Janssen, Bert J. C.; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Sub Structural Biochemistry; Structural Biochemistry; Pharmacology
Publicado en: Chemical Science, 2022, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sc07190d

β-lactam/β-lactamase inhibitor combinations: an update

Autores: Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin
Publicado en: MedChemComm, Edición 9/9, 2018, Página(s) 1439-1456, ISSN 2040-2503
Editor: Royal Society of Chemistry
DOI: 10.1039/c8md00342d

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Autores: Karol Al Ayed; Denise Zamarbide Losada; Nataliia V. Machushynets; Barbara Terlouw; Somayah S. Elsayed; Julian Schill; Vincent Trebosc; Michel Pieren; Marnix H. Medema; Gilles P. van Wezel; Nathaniel I. Martin
Publicado en: ACS Infectious Diseases, 2023, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.3c00043

A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens

Autores: Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin
Publicado en: Journal of Medicinal Chemistry, Edición 64/15, 2021, Página(s) 10890-10899, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00176

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Autores: Ned Buijs, Halana C. Vlaming, Matthijs J. van Haren, Nathaniel I. Martin
Publicado en: ChemBioChem, 2022, ISSN 1439-7633
Editor: Wiley
DOI: 10.1002/cbic.202200547

Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids

Autores: Slingerland, Cornelis J.; Wesseling, Charlotte M. J.; Innocenti, Paolo; Westphal, Koen G. C.; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Publicado en: Journal of Medicinal Chemistry, 2022, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01528

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

Autores: Thomas M. Wood, Nathaniel I. Martin
Publicado en: MedChemComm, Edición 10/5, 2019, Página(s) 634-646, ISSN 2040-2503
Editor: Royal Society of Chemistry
DOI: 10.1039/c9md00126c

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

Autores: Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin
Publicado en: Chemical Communications, Edición 56/20, 2020, Página(s) 3047-3049, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d0cc00356e

Dual targeting of the class V lanthipeptide antibiotic cacaoidin

Autores: Julia P. Deisinger; Melina Arts; Ioli Kotsogianni; Jan-Samuel Puls; Fabian Grein; Francisco Javier Ortiz-López; Nathaniel I. Martin; Anna Müller; Olga Genilloud; Tanja Schneider
Publicado en: iScience, 2023, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2023.106394

A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation

Autores: Liubov Yakovlieva; Thomas M. Wood; Thomas M. Wood; Johan Kemmink; Ioli Kotsogianni; Franziska Koller; Juergen Lassak; Nathaniel I. Martin; Marthe T. C. Walvoort
Publicado en: Chemical Science, 2021, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc05823h

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

Autores: Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Publicado en: ACS Infectious Diseases, Edición 6/6, 2020, Página(s) 1366-1371, ISSN 2373-8227
Editor: America Chemical Society
DOI: 10.1021/acsinfecdis.9b00459

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

Autores: Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin
Publicado en: Organic & Biomolecular Chemistry, Edición 18/3, 2020, Página(s) 514-517, ISSN 1477-0520
Editor: Royal Society of Chemistry
DOI: 10.1039/c9ob02534k