Pubblicazioni Peer reviewed articles (30) Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance Autori: Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin Pubblicato in: Chemistry – A European Journal, Numero 27/11, 2021, Pagina/e 3806-3811, ISSN 0947-6539 Editore: John Wiley & Sons Ltd. DOI: 10.1002/chem.202004694 Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption Autori: Nathaniel Martin; Angeliki Ioli Kotsogianni Teftsoglou; Charlotte Wesseling; Cornelis Jacob Slingerland Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.2c00307 Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+ Autori: David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright Pubblicato in: Journal of Biological Chemistry, Numero 297/2, 2021, Pagina/e 100918, ISSN 0021-9258 Editore: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1016/j.jbc.2021.100918 Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine. Autori: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane Pubblicato in: RSC Medicinal Chemistry, 2022, ISSN 2632-8682 Editore: Royal Society of Chemistry DOI: 10.1039/d2md00281g Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy Autori: Karol Al Ayed; Ross D. Ballantine; Michael Hoekstra; Samantha J. Bann; Charlotte M. J. Wesseling; Alexander T. Bakker; Zheng Zhong; Yong-Xin Li; Nora C. Brüchle; Mario van der Stelt; Stephen A. Cochrane; Nathaniel I. Martin Pubblicato in: Chemical Science, 2022, ISSN 2041-6539 Editore: Royal Society of Chemistry DOI: 10.1039/d2sc00143h Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity Autori: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane Pubblicato in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804 Editore: American Chemical Society DOI: 10.1021/acs.jmedchem.3c00308 Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens. Autori: Charlotte M J Wesseling; Cornelis J Slingerland; Shanice Veraar; Samantha Lok; Nathaniel I. Martin Pubblicato in: ACS Infectious Diseases, 2021, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.1c00466 Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin Autori: Ioli Kotsogianni; Thomas M. Wood; Francesca M. Alexander; Stephen A. Cochrane; Nathaniel I. Martin Pubblicato in: ACS Infectious Diseases, 2021, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.1c00316 Vancomycin-Polymyxin Nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains Autori: Groesen, Emma van; Slingerland, Cornelis J.; Innocenti, Paolo; Mihajlovic, Milos; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology Pubblicato in: ACS Infectious Diseases, 2021, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.1c00318 Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022 Autori: Emma van Groesen; Paolo Innocenti; Nathaniel I. Martin Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.2c00253 Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA Autori: Bakker, A.T.; Kotsogianni, A.I.; Mirenda, L.; Straub, V.M.; Avalos Garcia, M.; Berg, R.J.B.H.N. van den; Florea, B.I.; Wezel, G.P. van; Janssen, A.P.A.; Martin, N.I.; Stelt, M. van der Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 1520-5126 Editore: American Chemical Society DOI: 10.1021/jacs.2c10819 opening the door for gram-positive specific antibiotics Autori: Nathaniel Martin; Charlotte Wesseling Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.2c00193 Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases Autori: Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin Pubblicato in: Journal of Medicinal Chemistry, Numero 64/13, 2021, Pagina/e 9141-9151, ISSN 0022-2623 Editore: American Chemical Society DOI: 10.1021/acs.jmedchem.1c00362 Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages Autori: Ali Javed; Cornelis J. Slingerland; Thomas M. Wood; Nathaniel I. Martin; Femke Broere; Markus H. Weingarth; Edwin J. A. Veldhuizen Pubblicato in: ACS Infectious Diseases, 2023, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.2c00518 Metabolic labeling probes for interrogation of the host–pathogen interaction Autori: Bob J Ignacio; Thomas Bakkum; Kimberly M. Bonger; Nathaniel I. Martin; Sander I. van Kasteren Pubblicato in: Organic & Biomolecular Chemistry, 2021, ISSN 1477-0539 Editore: Royal Society of Chemistry DOI: 10.1039/d0ob02517h Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. Autori: Charlotte M J Wesseling; Thomas M. Wood; Thomas M. Wood; Kristine Bertheussen; Samantha Lok; Nathaniel I. Martin Pubblicato in: Molecules, 2021, ISSN 1420-3049 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules26071954 Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition** Autori: Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin Pubblicato in: ChemMedChem, Numero 16/10, 2021, Pagina/e 1651-1659, ISSN 1860-7179 Editore: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.202100042 Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494. Autori: Nicola Wade; Charlotte M. J. Wesseling; Paolo Innocenti; Cornelis J. Slingerland; Gregory M. Koningstein; Joen Luirink; Nathaniel I. Martin Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.2c00459 Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures Autori: Wood, Thomas M.; Zeronian, Matthieu R.; Buijs, Ned; Bertheussen, Kristine; Abedian, Hanieh K.; Johnson, Aidan V.; Pearce, Nicholas M.; Lutz, Martin; Kemmink, Johan; Seirsma, Tjalling; Hamoen, Leendert W.; Janssen, Bert J. C.; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Sub Structural Biochemistry; Structural Biochemistry; Pharmacology Pubblicato in: Chemical Science, 2022, ISSN 2041-6539 Editore: Royal Society of Chemistry DOI: 10.1039/d1sc07190d β-lactam/β-lactamase inhibitor combinations: an update Autori: Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin Pubblicato in: MedChemComm, Numero 9/9, 2018, Pagina/e 1439-1456, ISSN 2040-2503 Editore: Royal Society of Chemistry DOI: 10.1039/c8md00342d Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability Autori: Karol Al Ayed; Denise Zamarbide Losada; Nataliia V. Machushynets; Barbara Terlouw; Somayah S. Elsayed; Julian Schill; Vincent Trebosc; Michel Pieren; Marnix H. Medema; Gilles P. van Wezel; Nathaniel I. Martin Pubblicato in: ACS Infectious Diseases, 2023, ISSN 2373-8227 Editore: American Chemical Society DOI: 10.1021/acsinfecdis.3c00043 A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens Autori: Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin Pubblicato in: Journal of Medicinal Chemistry, Numero 64/15, 2021, Pagina/e 10890-10899, ISSN 0022-2623 Editore: American Chemical Society DOI: 10.1021/acs.jmedchem.1c00176 Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups Autori: Ned Buijs, Halana C. Vlaming, Matthijs J. van Haren, Nathaniel I. Martin Pubblicato in: ChemBioChem, 2022, ISSN 1439-7633 Editore: Wiley DOI: 10.1002/cbic.202200547 Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids Autori: Slingerland, Cornelis J.; Wesseling, Charlotte M. J.; Innocenti, Paolo; Westphal, Koen G. C.; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology Pubblicato in: Journal of Medicinal Chemistry, 2022, ISSN 0022-2623 Editore: American Chemical Society DOI: 10.1021/acs.jmedchem.2c01528 The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry Autori: Thomas M. Wood, Nathaniel I. Martin Pubblicato in: MedChemComm, Numero 10/5, 2019, Pagina/e 634-646, ISSN 2040-2503 Editore: Royal Society of Chemistry DOI: 10.1039/c9md00126c Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1 Autori: Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin Pubblicato in: Chemical Communications, Numero 56/20, 2020, Pagina/e 3047-3049, ISSN 1359-7345 Editore: Royal Society of Chemistry DOI: 10.1039/d0cc00356e Dual targeting of the class V lanthipeptide antibiotic cacaoidin Autori: Julia P. Deisinger; Melina Arts; Ioli Kotsogianni; Jan-Samuel Puls; Fabian Grein; Francisco Javier Ortiz-López; Nathaniel I. Martin; Anna Müller; Olga Genilloud; Tanja Schneider Pubblicato in: iScience, 2023, ISSN 2589-0042 Editore: Cell Press DOI: 10.1016/j.isci.2023.106394 A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation Autori: Liubov Yakovlieva; Thomas M. Wood; Thomas M. Wood; Johan Kemmink; Ioli Kotsogianni; Franziska Koller; Juergen Lassak; Nathaniel I. Martin; Marthe T. C. Walvoort Pubblicato in: Chemical Science, 2021, ISSN 2041-6539 Editore: Royal Society of Chemistry DOI: 10.1039/d0sc05823h Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem Autori: Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin Pubblicato in: ACS Infectious Diseases, Numero 6/6, 2020, Pagina/e 1366-1371, ISSN 2373-8227 Editore: America Chemical Society DOI: 10.1021/acsinfecdis.9b00459 The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics Autori: Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin Pubblicato in: Organic & Biomolecular Chemistry, Numero 18/3, 2020, Pagina/e 514-517, ISSN 1477-0520 Editore: Royal Society of Chemistry DOI: 10.1039/c9ob02534k È in corso la ricerca di dati su OpenAIRE... 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