Immune Signatures for Therapy Stratification in Major Mood Disorders

Deliverables

Demonstrators, pilots, prototypes (2)

A kit protocol for the discriminating serum cytokines/growth factors

A kit protocol for the ELISA’s for hCRP, IL-6, IL-10, CCL2, PTX3, sCD25, IL-7, SCF, IGFBP-2 and BDNF (or a selection of those factors) and other found serum cytokines and growth factors discriminating active mood disorders and helpful in determining therapy responsiveness.

A PAXGENE kit protocol

A kit protocol for a Q-PCR on PAXGENE material for the key genes of cluster 1 and 2 , the IFN cluster and, if relevant, also for growth and apoptosis genes discriminating active mood disorders and helpful in determining therapy responsiveness.

Websites, patent fillings, videos etc. (9)

Website update M12

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

List of seminars for patients M24

Reports and programs of seminars organized for patient organizations

Website update M1

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M30

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

General public communications M24

A two-yearly list of lay press articles, television documentaries and other general public communications

Website update M6

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M36

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M24

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M18

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Documents, reports (8)

Kick off report

Report of the kick off meeting

Abstract list M24

A yearly list of abstracts of contributions to scientific meetings

First annual meeting report

Report of the first annual meeting of the general assembly

Midterm meeting report

Report of the midterm meeting of the general assembly, with special emphasis on the decisions made with regard to the final composition of the immune signatures and the decisions made on the choice for anti-inflammatory and T cell enforcement therapies

Data management plan

A data management plan

Ethical approval treatment as usual study

First study subject approvals package for the study with treatment as usual (simple recording of improvement of mood state in patients)

Ethical approval IL-2 study

First study subject approvals package for the low dose IL-2 clinical investigations

Mood state in CVID

Report on the study on the prevalence of fatigue and depression in CVID patients with and without reduced numbers of T cells

Publications

Peer reviewed articles (14)

Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression

Author(s): Carmen Schiweck, Stephan Claes, Lukas Van Oudenhove, Ginette Lafit, Thomas Vaessen, Gommaar Op de Beeck, Raf Berghmans, Annemarie Wijkhuijs, Norbert Müller, Volker Arolt, Hemmo Drexhage, Elske Vrieze
Published in: Translational Psychiatry, Issue 10/1, 2020, ISSN 2158-3188
DOI: 10.1038/s41398-020-00979-z

T-cell defects and postpartum depression

Author(s): Lauren M. Osborne, Janneke Gilden, Astrid M. Kamperman, Witte J.G. Hoogendijk, Julie Spicer, Hemmo A. Drexhage, Veerle Bergink
Published in: Brain, Behavior, and Immunity, Issue 87, 2020, Page(s) 397-403, ISSN 0889-1591
DOI: 10.1016/j.bbi.2020.01.007

Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells

Author(s): Carmen Schiweck, Mireia Valles-Colomer, Volker Arolt, Norbert Müller, Jeroen Raes, Annemarie Wijkhuijs, Stephan Claes, Hemmo Drexhage, Elske Vrieze
Published in: Brain, Behavior, and Immunity, Issue 87, 2020, Page(s) 603-609, ISSN 0889-1591
DOI: 10.1016/j.bbi.2020.02.005

Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder

Author(s): Sara Poletti, Mario Gennaro Mazza, Benedetta Vai, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Published in: Frontiers in Psychiatry, Issue 11, 2020, ISSN 1664-0640
DOI: 10.3389/fpsyt.2020.590095

Cause-specific life years lost in individuals with treatment-resistant depression: A Danish nationwide register-based cohort study

Author(s): Kathrine Bang Madsen, Oleguer Plana-Ripoll, Katherine L. Musliner, Jean-Christophe Philippe Debost, Liselotte Vogdrup Petersen, Trine Munk-Olsen
Published in: Journal of Affective Disorders, Issue 280, 2021, Page(s) 250-257, ISSN 0165-0327
DOI: 10.1016/j.jad.2020.11.042

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin

Author(s): Thomas A Pollak, Belinda R Lennox, Sabine Müller, Michael E Benros, Harald Prüss, Ludger Tebartz van Elst, Hans Klein, Johann Steiner, Thomas Frodl, Bernhard Bogerts, Li Tian, Laurent Groc, Alkomiet Hasan, Bernhard T Baune, Dominique Endres, Ebrahim Haroon, Robert Yolken, Francesco Benedetti, Angelos Halaris, Jeffrey H Meyer, Hans Stassen, Marion Leboyer, Dietmar Fuchs, Markus Otto, David A Brow
Published in: The Lancet Psychiatry, Issue 7/1, 2020, Page(s) 93-108, ISSN 2215-0366
DOI: 10.1016/s2215-0366(19)30290-1

Childhood Adversity and Current Stress are related to Pro- and Anti-inflammatory Cytokines in Major Depression

Author(s): Norbert Müller, Daniela Krause, Rike Barth, Aye-Mu Myint, Elif Weidinger, Waltraud Stettinger, Peter Zill, Hemmo Drexhage, Markus J. Schwarz
Published in: Journal of Affective Disorders, Issue 253, 2019, Page(s) 270-276, ISSN 0165-0327
DOI: 10.1016/j.jad.2019.04.088

Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium

Author(s): Gara Arteaga-Henríquez, Maria S. Simon, Bianka Burger, Elif Weidinger, Annemarie Wijkhuijs, Volker Arolt, Tom K. Birkenhager, Richard Musil, Norbert Müller, Hemmo A. Drexhage
Published in: Frontiers in Psychiatry, Issue 10, 2019, ISSN 1664-0640
DOI: 10.3389/fpsyt.2019.00458

Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Author(s): Sara Poletti, Giovanni Leone, Thomas A. Hoogenboezem, Davide Ghiglino, Benedetta Vai, Harm de Wit, Annemarie J.M. Wijkhuijs, Clara Locatelli, Cristina Colombo, Hemmo A. Drexhage, Francesco Benedetti
Published in: Psychiatry Research: Neuroimaging, Issue 285, 2019, Page(s) 64-66, ISSN 0925-4927
DOI: 10.1016/j.pscychresns.2019.01.009

Editorial: Activation and de-activation of inflammatory pathways. The disequilibrium of immune-neuro-endocrine networks in psychiatric disorders

Author(s): Hemmo A Drexhage
Published in: Brain, Behavior, and Immunity, Issue 78, 2019, Page(s) 5-6, ISSN 0889-1591
DOI: 10.1016/j.bbi.2019.01.007

Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder

Author(s): G. Snijders, R. Brouwer, S. Kemner, F. Bootsman, H. A. Drexhage, M. H. J. Hillegers
Published in: International Journal of Bipolar Disorders, Issue 7/1, 2019, ISSN 2194-7511
DOI: 10.1186/s40345-018-0139-3

Th17/T regulator cell balance and NK cell numbers in relation to psychosis liability and social stress reactivity

Author(s): J. Counotte, H.A. Drexhage, J.M. Wijkhuijs, R. Pot-Kolder, V. Bergink, H.W. Hoek, W. Veling
Published in: Brain, Behavior, and Immunity, Issue 69, 2018, Page(s) 408-417, ISSN 0889-1591
DOI: 10.1016/j.bbi.2017.12.015

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder

Author(s): Karlijn Becking, Bartholomeus C.M. Haarman, Laura Grosse, Willem A. Nolen, Stephan Claes, Volker Arolt, Robert A. Schoevers, Hemmo A. Drexhage
Published in: Journal of Neuroimmunology, Issue 319, 2018, Page(s) 28-36, ISSN 0165-5728
DOI: 10.1016/j.jneuroim.2018.03.004

Early labor force exits in patients with treatment-resistant depression: an assessment of work years lost in a Danish nationwide register-based cohort study

Author(s): Kathrine Bang Madsen, Liselotte Vogdrup Petersen, Oleguer Plana-Ripoll, Katherine L. Musliner, Jean-Christophe Philippe Debost, Frederikke Hordam Gronemann, Preben Bo Mortensen, Trine Munk-Olsen
Published in: Therapeutic Advances in Psychopharmacology, Issue 10, 2020, Page(s) 204512532097379, ISSN 2045-1253
DOI: 10.1177/2045125320973791