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Optimizing response to Li treatment through personalized evaluation of individuals with bipolar I disorder: the R-LiNK initiative

Objective

Bipolar disorder (BD) is a prevalent mental disorder and a leading cause of suicide. Lithium (Li) is the key mood stabilizer for prevention of BD relapse and suicide. Whilst many cases become asymptomatic with Li treatment, the majority show sub-optimal response. Identifying biomarkers for predicting Liresponse would enable personalization of treatment, define criteria for stratification of BD cases and further refine the clinical response phenotype.
The objectives of this proposal are to (i) improve outcomes of bipolar I disorder (BDI) cases prescribed Li through the application of stratified approaches; (ii) optimize the early prediction of lLi response using a set of multi-modal biomarkers (“blood omics”, Magnetic Resonance Imaging and Li7-Magnetic Resonance Imaging derived-markers); (iii) develop a multidisciplinary multinational network of experts to undertake this and future projects on personalized diagnostics and therapeutics; and (iv) implement new, powerful technologies to characterize brain Li distribution and the blood molecular signature of Li in responders and non-responders. This cutting edge approach will identify the eligibility criteria for treatment with Li in BD in terms of response, safety and tolerability. The assessment of each putative biomarker (singly and combined) will be guided by preliminary findings already obtained by R-LiNK; our expertise will allow exploratory analyses and innovative modelling of multi-modal data.
Likely impacts include improved outcomes and quality of life for BDI cases; development of a screening tool for clinicians; and an evaluation of the cost-effectiveness of this stratified approach. The network will develop new avenues of research on Li mechanisms of action and disease mechanisms; our industrial partnerships will enable development of medical devices to improve treatment adherence and patient’s autonomy, diagnostic kits, and tools based on the molecular signature in treatment responders.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2017-Two-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 438 750,00
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (26)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON
France
Net EU contribution
€ 114 885,00
Address
Place Saint Jacques 2
25030 Besancon Cedex
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Bourgogne-Franche-Comté Franche-Comté Doubs
INSERM TRANSFERT SA
France
Net EU contribution
€ 349 000,00
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI
Italy
Net EU contribution
€ 401 270,00
Address
Via Pilastroni 4
25125 Brescia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
GOETEBORGS UNIVERSITET
Sweden
Net EU contribution
€ 145 943,75
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Södra Sverige Västsverige Västra Götalands län
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 299 235,00
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITAET DRESDEN
Germany
Net EU contribution
€ 408 485,00
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITETET I OSLO
Norway
Net EU contribution
€ 76 250,00
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 107 500,00
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
Net EU contribution
€ 137 347,50
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 0,00
Address
Calle Villarroel 170
08036 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 211 080,00
CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain
Net EU contribution
€ 133 760,50
Address
Paseo Maritim 25-29
08003 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ALCYM
France
Net EU contribution
€ 270 155,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
1 Rue De La Glaciere
25660 Saone
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Bourgogne-Franche-Comté Franche-Comté Doubs
 
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 237 500,00
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 234 035,10
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 975 877,50
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Net EU contribution
€ 293 453,75
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
Net EU contribution
€ 54 350,00
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 272 131,25
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
North East (England) Northumberland and Tyne and Wear Tyneside
ACOBIOM
France
Net EU contribution
€ 550 000,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
1682 Rue De La Valsiere Cap Delta Zac Euromedecine Ii
34790 Grabels
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 349 651,25
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 798 093,00
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MONSENSO A/S
Denmark
Net EU contribution
€ 381 250,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Ny Carlsberg Vej 80
1799 Copenhagen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Danmark Hovedstaden Byen København
 
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 485 360,00
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
Net EU contribution
€ 137 750,00
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

JOHANNES GUTENBERG-UNIVERSITAT MAINZ

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Saarstrasse 21
55122 Mainz
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
UNIVERSITY OF GREENWICH
United Kingdom
Net EU contribution
€ 50 498,65
Address
Park Row Greenwich Old Royal Naval College
SE10 9LS London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
London Outer London — East and North East Bexley and Greenwich