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The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Objective

Rejection is the major cause of allograft failure with dramatic consequences in terms of mortality, morbidity and increased cost for the society. The field of transplantation lacks a robust assessment of risk stratification. Thus, it impairs the development of relevant clinical trials to address graft and patient outcomes. We formed the EU-TRAIN project by gathering reference kidney transplant centres in a fully operating European network including 12 partners. Our ambitious but realistic goals are: to provide clinicians with innovative and accessible tools for early prediction of individual risk of allograft rejection and transplant loss; to personalise clinical management and treatment and; to improve allograft outcomes. This project will engineer a risk stratification system applied to kidney transplant patients by analysing the integration of several layers of data (clinical, histological, immunological data as well as gene expression and novel biomarkers) - the TRAnsplant Comprehensive Evaluator of Risk (EU-TRACER). EU-TRACER will be generated and validated in 2 dedicated studies including a randomised control trial. Translation to patients will be achieved by delivering: 1) A multiplex non-invasive biomarker system for the stratification and immune monitoring of low and high risk kidney recipients; 2) A prognostic system for individual risk stratification for allograft rejection and failure that will assist decision making via an interactive web interface. The EU-TRACER, developed with our 3 industrial partners, will define a new standard of care in transplantation. The EU-TRACER will have the potential for a large implementation and diffusion in other centres in Europe and will be suitable for industrial collaboration.
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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Research Organisations

EU Contribution

€ 1 025 447

Participants (11)

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INSTITUT CATALA DE LA SALUT

Spain

EU Contribution

€ 750 597

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 898 236

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 1 154 520

CELLTREND GESELLSCHAFT MIT BESCHRANKTER HAFTUNG

Germany

EU Contribution

€ 208 313

INSERM - TRANSFERT SA

France

EU Contribution

€ 391 875

OXFORD IMMUNOTEC LIMITED

United Kingdom

EU Contribution

€ 303 841

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

France

EU Contribution

€ 1 207 741

CERNER FRANCE

France

EU Contribution

€ 96 563

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 444 413

EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION

Netherlands

EU Contribution

€ 120 000

ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK

France

EU Contribution

€ 40 000

Project information

Grant agreement ID: 754995

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 641 546

  • EU contribution

    € 6 641 546

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France