The Mechanisms and Dynamics Controlling Cycles of Lymph Node Expansion

Projektinformationen

LNEXPANDS

ID Finanzhilfevereinbarung: 757573

DOI 10.3030/757573

Projekt abgeschlossen

EK-Unterschriftsdatum 3 November 2017

Startdatum 1 März 2018

Enddatum 31 August 2023

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 1 500 000,00

EU-Beitrag € 1 500 000,00

Koordiniert durch

UNIVERSITY COLLEGE LONDON
United Kingdom

Ziel

Lymph node swelling is a classical hallmark of immunity. This expansion is observed by doctors, researchers and patients, yet as obvious as this process is, our understanding of the remodelling mechanisms involved are in their infancy. Lymph node remodelling is rapid and yet completely reversible, occurring countless times throughout our lifetimes. The purpose of this proposal is to understand how lymph node remodelling occurs and is resolved, repeatedly; to understand immunity in a whole organ context.
The architecture of lymphoid organs is key to the effective operation of our immune system and is dictated by structures formed by non-haematopoetic stromal cells, including endothelial cells, and fibroblasts. Beyond their structural roles, stromal cells play an active role in immune responses, and the field of stromal immunology has become one of the most dynamic and exciting areas of immunology research. In this proposal I focus on the changing behaviour of fibroblastic reticular cells (FRCs) throughout cycles of lymph node remodelling. Fibroblastic reticular cells (FRCs) are the most abundant lymphoid stromal cell population, and form an interconnected network spanning the full volume of the tissue. FRCs are highly contractile and are able to relax and stretch during early phases of lymph node remodelling. FRCs proliferate during later phases of lymph node growth but are then removed as homeostasis is restored. Throughout this proposal I will use an extensive range of systems, ranging from proteomics and biochemistry to intravital imaging.
I aim to: 1) To discover how spreading and stretching of the existing fibroblastic reticular network is directed in the acute phase of expansion: 2) To discover the cellular cues inducing the switch from stretching to proliferation and growth of the fibroblastic reticular network and 3) understand how homeostasis is regained as immune responses are resolved.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › physiology › homeostasis

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2017-STG - ERC Starting Grant

Aufforderung zur Vorschlagseinreichung

ERC-2017-STG

Finanzierungsplan

ERC-STG - Starting Grant

Gastgebende Einrichtung

UNIVERSITY COLLEGE LONDON

• Netto-EU-Beitrag: € 1 500 000,00
• Adresse: GOWER STREET ; WC1E 6BT London ; Vereinigtes Königreich
• Region: London › Inner London — West › Camden and City of London
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 500 000,00

Begünstigte (1)

UNIVERSITY COLLEGE LONDON

Vereinigtes Königreich

• Netto-EU-Beitrag: € 1 500 000,00
• Adresse: GOWER STREET ; WC1E 6BT London
• Region: London › Inner London — West › Camden and City of London
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 500 000,00