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Novel 1D photonic metal oxide nanostructures for early stage cancer detection

Novel 1D photonic metal oxide nanostructures for early stage cancer detection

Objective

The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas and
knowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors for
cancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool for
early stage cancer detection which can solve on of important health challenges in EU society. One dimensional (1D) polimer
nanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide based
nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au
nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will
be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy
will be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic
lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic
system in order to minimize dimensions and simplify the use of the detection system.
The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization,
bioengineering, microfluidics and biosensor testing, market analysis and commercialization. Provided research and
management training to experienced researchers and early stage researchers will strengthen their personal skills and CVs
via new scientific papers and conference theses and strengthen a development of EU research human resources. Long
lasting collaboration between partners, based on co-supervising students and preparation of novel collaborative project
proposals is foreseen. Dissemination of the project results to scientific society and wide auditories is foreseen.

Coordinator

LATVIJAS UNIVERSITATE

Address

Rainis Boulevard 19
1586 Riga

Latvia

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 423 000

Participants (7)

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VILNIAUS UNIVERSITETAS

Lithuania

EU Contribution

€ 207 000

ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER

France

EU Contribution

€ 112 500

UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU

Poland

EU Contribution

€ 333 000

FONDAZIONE BRUNO KESSLER

Italy

EU Contribution

€ 36 000

EESTI MATERJALITEHNOLOOGIATE ARENDUSKESKUSE OÜ

Estonia

EU Contribution

€ 58 500

BIOSENSOR SRL

Italy

EU Contribution

€ 49 500

NANOPHARMA AS

Czechia

EU Contribution

€ 63 000

Partners (1)

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Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus

Project information

Grant agreement ID: 778157

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 1 282 500

  • EU contribution

    € 1 282 500

Coordinated by:

LATVIJAS UNIVERSITATE

Latvia