Skip to main content
italianoIT
European Commission logo print header

Evolvable platform for programmable nanoparticle-based cancer therapies

Obiettivo

EVO-NANO aims to create an integrated cross-disciplinary platform for the artificial evolution and assessment of nanoparticle-based drug delivery systems. Nanoparticles (NP) are increasingly being studied in cancer research for their ability to improve diagnosis accuracy and/or deliver tailored treatments directly to tumours. However, their effective biodistribution is still a major limitation. The challenge is to discover how to program collective behaviour of the trillions of NP interacting in a complex tumour environment. Finding effective NP designs that give rise to desired outcome will require a new class of evolutionary algorithms that can simultaneously 1) generate novel NP-based anti-cancer strategies, 2) search over a large space of solutions, and 3) adapt to a wide variety of scenarios. Our novel evolutionary approach will be integrated with molecular dynamics simulations, PhysiCell (http://physicell.mathcancer.org) and STEPS simulators that reproduces realistic NP motion and interactions within the tumour environment and with other NP. The most promising NP designs will then be synthesized and tested in vivo and in vitro on breast and colon cancer stem cells using mouse cancer xenografts and microfluidic testbeds featuring cancer microenvironments. To promote translation of the platform from early stage research into a commercialized product for patients, we will work with industrial partner ProChimia Surfaces, organize ‘Industry Open Days’ for potential investors and develop a translation strategy.
EVO-NANO is a multidisciplinary project that will create an entirely novel NP design platform for new cancer treatments, capable of autonomously evolving both innovative and adaptive solutions. The proposed platform has the potential to be at the forefront of cancer nanomedicine by enabling much faster development and assessment of new cancer treatments, than is done today. The project will generate concrete tools for the predictive design of nanomedicines that could be applied in other clinical fields.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-FETOPEN-2016-2017

Vedi altri progetti per questo bando

Bando secondario

H2020-FETOPEN-1-2016-2017

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

UNIVERZITET U NOVOM SADU, POLJOPRIVREDNI FAKULTET NOVI SAD
Contribution nette de l'UE
€ 284 843,75
Indirizzo
TRG DOSITEJA OBRADOVICA 8
21000 Novi Sad
Serbia

Mostra sulla mappa
Regione
Србија - север Регион Војводине Јужнобачка област
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 284 843,75

Partecipanti (6)

Condividi questa pagina

Scarica

Ultimo aggiornamento: 29 Giugno 2023

Il mio booklet

Permalink: https://cordis.europa.eu/project/id/800983/it

European Union, 2024