Project description DEENESFRITPL Metabolic MRI for cardiovascular disease diagnosis Molecular characterisation of tissues is necessary to understand disease pathophysiology. Positron emission tomography (PET) is the only imaging modality that measures the metabolic activity of cells within tissues, but it is not suitable for understanding and characterising cardiovascular diseases. To address this limitation, the EU-funded MetaboliQs project has developed a novel method for magnetic resonance imaging (MRI) that provides information on the chemical state of the tissue. The method amplifies the MRI signal of metabolites by a thousand-fold generating important insight into metabolic activity at a fraction of the cost. The MetaboliQs method is expected to unlock novel diagnostic capabilities and advance personalised treatment of cardiovascular and other metabolic diseases. Show the project objective Hide the project objective Objective Cardiovascular Diseases (CVDs) are the number 1 cause of death globally: more people die annually from CVDs than from any other cause. Despite emerging diagnostics tools and therapeutics, several areas of significant unmet need remain unaddressed among CVD patients. The ability to personalize cardiovascular medical care and improve outcomes, will require characterization of disease processes at a molecular level. The current state-of-the-art, e.g. Positron emission tomography (PET), does not provide detailed information about the chemical state of the tissue at a molecular level, therefore it remains difficult to accurately diagnose and confidently select appropriate therapy in many circumstances. The MetaboliQs project brings together two areas of European excellence - diamond-based quantum sensing and medical imaging. We will translate a newly developed hyperpolarization method for magnetic resonance imaging (MRI) based on the quantum dynamics of nitrogen-vacancy (NV) centers. This breakthrough quantum technology will enable previously unachievable, highly sensitive quantification of metabolic activity, paving the way for precision diagnostics and better personalized treatment of cardiovascular and other metabolic diseases. For realizing and eventually commercializing the technology, MetaboliQs brings together a world-class multidisciplinary consortium with end to end expertise - leading diamond quantum technology research institutes (Fraunhofer IAF - quantum-grade diamond growth and fabrication, HUJI - quantum sensing) and innovative companies (Element 6 - worldwide leader in synthetic diamonds, NVision - inventor of diamond-based polarization), as well as two expert users of hyperpolarized and cardiovascular MRI (TUM, ETH Zurich - first in continental Europe to conduct clinical trials of hyperpolarized MRI for cardiovascular disease) and the market leader in electron paramagnetic resonance and preclinical MRI (Bruker). Fields of science medical and health sciencesclinical medicinecardiologycardiovascular diseasesengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Keywords diamond quantum dynamics hyperpolarisation metabolic imaging precision diagnostics cardiovascular diseases Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.3. - FET Flagships Topic(s) FETFLAG-03-2018 - FET Flagship on Quantum Technologies Call for proposal H2020-FETFLAG-2018-2020 See other projects for this call Sub call H2020-FETFLAG-2018-03 Funding Scheme RIA - Research and Innovation action Coordinator FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Net EU contribution € 1 500 172,50 Address Hansastrasse 27c 80686 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 500 172,50 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all NVISION IMAGING TECHNOLOGIES GMBH Germany Net EU contribution € 1 430 937,50 Address Wolfgang-paul-strasse 2 89081 Ulm See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 430 937,50 KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany Net EU contribution € 1 220 401,25 Address Ismaninger strasse 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 220 401,25 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland Net EU contribution € 936 812,50 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 936 812,50 BRUKER BIOSPIN GMBH Germany Net EU contribution € 228 800,00 Address Rudolf-plank-strasse 23 76275 Ettlingen See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 228 800,00 ELEMENT SIX (UK) LIMITED United Kingdom Net EU contribution € 960 290,00 Address Global innovation centre fermi avenue OX11 0QR Harwell oxfordshire didcot See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 960 290,00 THE HEBREW UNIVERSITY OF JERUSALEM Israel Net EU contribution € 390 387,50 Address Edmond j safra campus givat ram 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 390 387,50