Project description DEENESFRITPL Novel tests to identify chemicals that disrupt thyroid hormone delivery to the embryo Endocrine-disrupting chemicals (EDCs) are abundant. They are found in plastics, pesticides and flame retardants, leaking into the environment and food chain and accumulating in the human body. EDCs can disrupt the function of hormonal systems by mimicking hormones or blocking their normal action in the body. During the first few weeks of gestation, the foetus is unable to produce thyroid hormone and relies on maternal supply. It is known that EDCs in the maternal system can decrease circulating thyroid hormone, changing the levels that reach the foetus and resulting in a negative outcome. The EU-funded ATHENA project aims to develop new test methods to identify the EDCs that disrupt thyroid hormone delivery to the embryo, damaging brain development in utero. Show the project objective Hide the project objective Objective The ATHENA consortium aims to mobilise the scientific progress made in recent years to close critical gaps left open in test methods for thyroid hormone axis disrupting-chemicals. We will develop new methods for incorporation into existing OECD test guidelines that can capture the consequences of maternal thyroid hormone deficiency on the developing brain, due to disruption of delivery of thyroid hormones to the foetus. To make this possible, we will establish new endpoints for identifying down-stream effects on the developing brain in foetal and post-natal life. We will provide new test methods for chemicals that interfere with the delivery of thyroid hormones to the foetus and the adult brain across physiological barriers such as the placenta, the blood brain barrier and the blood brain cerebrospinal fluid barrier. We will also develop QSARs for the screening of large compound libraries and methods for capturing disruption of the local supply of thyroid hormone by inhibition of deiodinases, dehalogenases and cell membrane transporters. Based on the construction of AOP networks for adverse neurodevelopmental effects, we will deliver a comprehensive testing strategy that can protect from chemicals that have the potential to harm brain development in foetal life and adulthood by disrupting the availability of thyroid hormones. Finally, ATHENA will conceive strategies for the international harmonisation of screening, testing and hazard identification for thyroid hormone axis disrupting chemicals. ATHENA comprises world-leading endocrinologists, experts in endocrine disruption and experts in modelling brain function ex vivo who collectively will deliver a step change in thyroid disruptor testing. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicineobstetricsfetal medicinemedical and health sciencesbasic medicinetoxicology Keywords test methods thyroid hormone axis disruption Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) SC1-BHC-27-2018 - New testing and screening methods to identify endocrine disrupting chemicals Call for proposal H2020-SC1-BHC-2018-2020 See other projects for this call Sub call H2020-SC1-2018-Single-Stage-RTD Funding Scheme RIA - Research and Innovation action Coordinator BRUNEL UNIVERSITY LONDON Net EU contribution € 1 154 313,75 Address KINGSTON LANE UB8 3PH Uxbridge United Kingdom See on map Region London Outer London — West and North West Harrow and Hillingdon Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 154 313,75 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all DANMARKS TEKNISKE UNIVERSITET Denmark Net EU contribution € 1 251 857,50 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 251 857,50 CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany Net EU contribution € 997 330,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 997 330,00 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 498 610,21 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 652 917,50 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. MUSEUM NATIONAL D'HISTOIRE NATURELLE France Net EU contribution € 154 307,29 Address RUE CUVIER 57 75005 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 154 307,29 STICHTING VU Netherlands Net EU contribution € 698 130,00 Address DE BOELELAAN 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 698 130,00 ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands Net EU contribution € 778 372,50 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 778 372,50 OREBRO UNIVERSITY Sweden Net EU contribution € 157 255,00 Address FAKULTETSGATAN 1 70182 Orebro See on map Region Östra Sverige Östra Mellansverige Örebro län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 157 255,00 WATCHFROG France Net EU contribution € 576 505,00 Address 4 RUE PIERRE FONTAINE 91000 Evry See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Essonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 576 505,00 KARLSTADS UNIVERSITET Sweden Net EU contribution € 50 537,50 Address UNIVERSITETSGATAN 2 651 88 Karlstad See on map Region Norra Sverige Norra Mellansverige Värmlands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 50 537,50 RISE RESEARCH INSTITUTES OF SWEDEN AB Sweden Net EU contribution € 248 245,00 Address BRINELLGATAN 4 501 15 Boras See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 248 245,00 BUNDESINSTITUT FUER RISIKOBEWERTUNG Germany Net EU contribution € 0,00 Address MAX DOHRN STRASSE 8-10 10589 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 21 800,00
