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Repeat protein Function Refinement, Annotation and Classification of Topologies

Objective

The REFRACT proposal answers the RISE call, aiming at the promotion of an international and interdisciplinary collaboration on tandem repeat proteins (TRPs) through the sharing of knowledge and expertise between partners via staff exchanges. REFRACT is an international consortium aiming to extend our knowledge on the mechanism of TRP function and evolution, establishing a common classification and best practices. Starting from available state of the art computational tools and databases, which have been mostly developed by REFRACT participants, it aims drive a new level of TRP characterization leveraging the complementary expertise of 7 EU MS and 9 TC institutions in Latin America, with the latter providing useful complementary expertises. This aim will be achieved by the following steps:
Benchmarking different existing methods and defining their use-cases;
Coordinating the necessary next steps to analyze TRP roles in biological pathways and organism evolution;
Providing a detailed description of their mechanism of function, related to their structural properties, that can be of great importance in TRP-related medical research and biotechnological applications;
Building a unified and commonly accepted TRP classification from sequence and structure as well as characterizing the relationship between the two.
The REFRACT implementation will take advantage of the different expertises, supporting them by a combination of research-centered, training and dissemination activities. The secondment program is designed so that all the participating institutions will be actively involved not only in the production of scientific outcomes, but also be empowered with the responsibility of planning, monitoring and discussing project advancement. The broadest possible dissemination of the results will be achieved through dedicated activities, the propagation of results into ELIXIR core data resources (InterPro, and consequently UniProt) as well as possible industrial exploitation.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Address
Via 8 Febbraio 2
35122 Padova
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 556 600

Participants (6)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 225 400
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 358 800
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany
EU contribution
€ 266 800
Address
Saarstrasse 21
55122 Mainz
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 358 800
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN
Switzerland
EU contribution
€ 262 200
Address
Gertrudstrasse 15
8401 Winterthur
Activity type
Higher or Secondary Education Establishments
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 197 800
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments

Partners (9)

UNIVERSIDAD NACIONAL DE QUILMES
Argentina
Address
Roque Saenz Pena 352
B1876BXD Bernal
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD NACIONAL DE LA PLATA
Argentina
Address
Calle 7 776
1900 La Plata
Activity type
Higher or Secondary Education Establishments
PONTIFICIA UNIVERSIDAD CATOLICA DEL PERU
Peru
Address
Av Universitaria 1801
15088 Lima
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD PERUANA CAYETANO HEREDIA
Peru
Address
Honorio Delgado 430
31 Lima
Activity type
Higher or Secondary Education Establishments
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile
Address
Avenida Libertador Bernardo O'higgins 340
8331150 Santiago
Activity type
Higher or Secondary Education Establishments
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
Cuba
Address
Avenida 31 S/n, E/158 Y 190, Playa
10600 La Habana
Activity type
Research Organisations
UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO
Mexico
Address
Torre De Rectoria 9º. Piso, Ciudad Universitaria, D.f.
04510 Mexico Distrito Federal
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DEL CAUCA
Colombia
Address
Calle 5 4-70
19001 Popayan
Activity type
Higher or Secondary Education Establishments
CENTRO DE INVESTIGATION CIENTIFICACAUCASECO LIMITADA
Colombia
Address
Carrera 37 2 Bis No. 5E 08
760002 Cali
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)