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Repeat protein Function Refinement, Annotation and Classification of Topologies

Objective

The REFRACT proposal answers the RISE call, aiming at the promotion of an international and interdisciplinary collaboration on tandem repeat proteins (TRPs) through the sharing of knowledge and expertise between partners via staff exchanges. REFRACT is an international consortium aiming to extend our knowledge on the mechanism of TRP function and evolution, establishing a common classification and best practices. Starting from available state of the art computational tools and databases, which have been mostly developed by REFRACT participants, it aims drive a new level of TRP characterization leveraging the complementary expertise of 7 EU MS and 9 TC institutions in Latin America, with the latter providing useful complementary expertises. This aim will be achieved by the following steps:
Benchmarking different existing methods and defining their use-cases;
Coordinating the necessary next steps to analyze TRP roles in biological pathways and organism evolution;
Providing a detailed description of their mechanism of function, related to their structural properties, that can be of great importance in TRP-related medical research and biotechnological applications;
Building a unified and commonly accepted TRP classification from sequence and structure as well as characterizing the relationship between the two.
The REFRACT implementation will take advantage of the different expertises, supporting them by a combination of research-centered, training and dissemination activities. The secondment program is designed so that all the participating institutions will be actively involved not only in the production of scientific outcomes, but also be empowered with the responsibility of planning, monitoring and discussing project advancement. The broadest possible dissemination of the results will be achieved through dedicated activities, the propagation of results into ELIXIR core data resources (InterPro, and consequently UniProt) as well as possible industrial exploitation.

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA

Address

Via 8 Febbraio 2
35122 Padova

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 556 600

Participants (6)

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EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 225 400

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 358 800

JOHANNES GUTENBERG-UNIVERSITAT MAINZ

Germany

EU Contribution

€ 266 800

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 358 800

ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN

Switzerland

EU Contribution

€ 262 200

STOCKHOLMS UNIVERSITET

Sweden

EU Contribution

€ 197 800

Partners (9)

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UNIVERSIDAD NACIONAL DE QUILMES

UNIVERSIDAD NACIONAL DE LA PLATA

PONTIFICIA UNIVERSIDAD CATOLICA DEL PERU

UNIVERSIDAD PERUANA CAYETANO HEREDIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA

UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

UNIVERSIDAD DEL CAUCA

CENTRO DE INVESTIGATION CIENTIFICACAUCASECO LIMITADA

Project information

Grant agreement ID: 823886

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 2 392 000

  • EU contribution

    € 2 226 400

Coordinated by:

UNIVERSITA DEGLI STUDI DI PADOVA

Italy