Deliverables Open Research Data Pilot (1) A Data Management Plan with ORDP A Data Management Plan with ORDP Documents, reports (11) Dissemination and exploitation plan Dissemination and exploitation plan Standard operating procedures in English and Spanish Standard operating procedures in English and Spanish Midterm report on the evaluation of risk factors related to HBV-induced HCC. Midterm report on the evaluation of risk factors related to HBVinduced HCC A Quality Assurance Plan A Quality Assurance Plan Midterm recruitment report of GBC patients Midterm recruitment report of GBC patients Third dissemination report Third dissemination report Midterm recruitment report of HCC patients and patients at risk of developing HCC Midterm recruitment report of HCC patients and patients at risk of developing HCC First dissemination report First dissemination report Report of the kick-off meeting Report of the kick-off meeting Midterm recruitment report of CCA patients and patients predisposed to develop CCA Midterm recruitment report of CCA patients and patients predisposed to develop CCA Second dissemination report Second dissemination report Websites, patent fillings, videos etc. (1) Public website and social media profiles Public website and social media profiles Other (1) Completion of trainings at all sites Completion of trainings at all sites Publications Peer reviewed articles (71) Circulating cytokines reflect the etiology-specific immune environment in cirrhosis and HCC Author(s): Beudeker BJB, Groothuismink ZMA, van der Eijk AA, Debes JD, Boonstra A. Published in: Cancers (Basel), 2022, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14194900 Medical therapy of HCC Author(s): Vogel A, Saborowski A. Published in: Journal of Hepatology, 2021, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2021.05.017 Next-Generation Biomarkers for Cholangiocarcinoma Author(s): Pedro Miguel Rodrigues, Arndt Vogel, Marco Arrese, Domingo C. Balderramo, Juan W. Valle, Jesus Maria Banales Published in: Cancers, 2021, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13133222 Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review. Author(s): Rohan Shotton, Angela Lamarca, Juan Valle, Mairéad G McNamara. Published in: World Journal of Gastrointestinal Oncology., 2021, ISSN 1948-5204 Publisher: Baishideng Publishing Group DOI: 10.4251/wjgo.v13.i9.1073 Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia Author(s): Lorena Rosa, Lorena Lobos‐González, Natalia Muñoz‐Durango, Patricia García, Carolina Bizama, Natalia Gómez, Ximena González, Ignacio A. Wichmann, Nicolás Saavedra, Francisca Guevara, Jaime Villegas, Marco Arrese, Catterina Ferreccio, Alexis M. Kalergis, Juan Francisco Miquel, Jaime A. Espinoza, Juan C. Roa Published in: Molecular Oncology, 2020, ISSN 1574-7891 Publisher: Elsevier BV DOI: 10.1002/1878-0261.12766 Molecular profiling and precision medicine in rare gastrointestinal cancers within EURACAN in the SPECTA Arcagen study (EORTC-1843): too few patients treated in Europe. Author(s): Angela Lamarca, Marie Morfouace, Sabine Tejpar, Julio Oliveira, Andreia Capela, Nicolas Penel, Christine Gennigens, Birute Brasiuniene, Julien Peron, Aleksandra Stevovic, Jean-Yves Blay, Heinz-Josef Klümpen. Published in: Annals of Oncology, 2022, ISSN 0923-7534 Publisher: Oxford University Press DOI: 10.1016/j.annonc.2022.07.006 Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary Author(s): Alicia-Marie Conway, Georgina C. Morris, Sarah Smith, Monique Vekeria, Prakash Manoharan, Claire Mitchell, Alison Backen, Pedro Oliveira, Richard A. Hubner, Angela Lamarca, Mairéad G. McNamara, Juan W. Valle and Natalie Cook Published in: British Journal of Cancer, 2022, ISSN 1532-1827 Publisher: Nature DOI: 10.1038/s41416-022-01824-4 Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic Author(s): Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L. Published in: Expert Opin Investig Drugs., 2021, ISSN 1354-3784 Publisher: Ashley Publications Ltd. DOI: 10.1080/13543784.2021.1880564 Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy Author(s): Roseanna C Wheatley, Elaine Kilgour, Timothy Jacobs, Angela Lamarca, Richard A Hubner , Juan W Valle, Mairéad G McNamara Published in: British Journal of Cancer, 2022, ISSN 1532-1827 Publisher: Nature DOI: 10.1038/s41416-021-01583-8 Liver metastases of intrahepatic cholangiocarcinoma: implications for a potential new staging system. Author(s): Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle Published in: Hepatology, 2020, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.31598 The Emerging Role of PIWI-Interacting RNAs (piRNAs) in Gastrointestinal Cancers: An Updated Perspective Author(s): Riquelme I, Pérez-Moreno P, Letelier P, Brebi P, Roa JC Published in: Cancers, 2022, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14010202 Current and novel therapeutic opportunities for systemic therapy in biliary cancer Author(s): José J. G. Marin, Maria Giuseppina Prete, Angela Lamarca, Simona Tavolari, Ana Landa-Magdalena, Giovanni Brandi, Oreste Segatto, Arndt Vogel, Rocío I. R. Macias, Pedro M. Rodrigues, Adelaida La Casta, Joachim Mertens, Cecilia M. P. Rodrigues, Maite G. Fernandez-Barrena, Ana Da Silva Ruivo, Marco Marzioni, Giulia Mentrasti, Pilar Acedo, Patricia Munoz-Garrido, Vincenzo Cardinale, Jesus M. Banales Published in: British Journal of Cancer, Issue 123/7, 2020, Page(s) 1047-1059, ISSN 0007-0920 Publisher: Nature Publishing Group DOI: 10.1038/s41416-020-0987-3 A look back at cholangiocarcinoma in Finland Author(s): Izquierdo-Sanchez L, Banales JM, Rodrigues PM. Published in: United European Gastroenterol J, 2021, ISSN 2050-6414 Publisher: SAGE Publications Inc. DOI: 10.1002/ueg2.12157 Hepatocellular carcinoma in nonalcoholic fatty liver disease: A growing challenge Author(s): Mattos ÂZ, Debes JD, Dhanasekaran R, Benhammou JN, Arrese M, Patrício ALV, Zilio AC, Mattos AA. Published in: World Journal of Hepatology, 2021, ISSN 1948-5182 Publisher: Baishideng Publishing Group DOI: 10.4254/wjh.v13.i9.1107 Combination therapies for targeting FGFR2 fusions in cholangiocarcinoma. Author(s): Saborowski A, Vogel A, Segatto O. Published in: Trends Cancer., 2021, ISSN 2405-8033 Publisher: Cell Press DOI: 10.1016/j.trecan.2021.11.001 Hepatitis B core‐related antigen levels predict recurrence‐free survival in patients with HBV‐associated early‐stage hepatocellular carcinoma: results from a Dutch long‐term follow‐up study Author(s): Boris J. B. Beudeker, Zwier M. A. Groothuismink, Robert A. Man, Caroline D. M. Witjes, Annemiek A. Eijk, Andre Boonstra, Milan J. Sonneveld Published in: Journal of Viral Hepatitis, Issue 28/1, 2021, Page(s) 205-208, ISSN 1352-0504 Publisher: Blackwell Publishing Inc. DOI: 10.1111/jvh.13394 Use of the Rockwood Clinical Frailty Scale in patients with advanced hepatopancreaticobiliary malignancies Author(s): Dinakshi Shah, Zainul Abedin Kapacee, Angela Lamarca, Richard A Hubner, Juan W Valle & Mairéad G McNamara Published in: Expert Review of Anticancer Therapy, 2022, ISSN 1744-8328 Publisher: Taylor & Francis DOI: 10.1080/14737140.2022.2096594 Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions Author(s): Macias RIR, Cardinale V, Kendall TJ, Avila MA, Guido M, Coulouarn C, Braconi C, Frampton AE, Bridgewater J, Overi D, Pereira SP, Rengo M, Kather JN, Lamarca A, Pedica F, Forner A, Valle JW, Gaudio E, Alvaro D, Banales JM, Carpino G. Published in: Gut, 2022, ISSN 1468-3288 Publisher: BMJ DOI: 10.1136/gutjnl-2022-327099 HPB cancers in older patients | inclusion of older/senior patients in clinical trials Author(s): Alison Backen, Angela Lamarca, Richard A. Hubner, Mairéad G. McNamara, Juan W. Valle Published in: European Journal of Surgical Oncology, Issue 47/3, 2021, Page(s) 597-602, ISSN 0748-7983 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.ejso.2020.11.002 Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance Author(s): Qian Wan, Chimaobi Anugwom, Hailemichael Desalegn , Jose D Debes Published in: Hepatoma research, 2022, ISSN 2454-2520 Publisher: OAE Publishing Inc. DOI: 10.20517/2394-5079.2022.32 Work-up and outcome of hepatic resection for peri-hilar cholangiocarcinoma (PH-CCA) without staging laparoscopy Author(s): Santhalingam Jegatheeswaran, Panagiotis Stathakis, Harry V M Spiers, Fawwaz Mohammed, Panagiotis Petras, Thomas Satyadas, Michael Parker, Angela Lamarca, Saurabh Jamdar, Aali J Sheen, Ajith Kumar Siriwardena Published in: Cancers (Basel), 2022, Page(s) 1841, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14071841 A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma Author(s): Rocio I. R. Macias, Luis Muñoz-Bellvís, Anabel Sánchez-Martín, Enara Arretxe, Ibon Martínez-Arranz, Ainhoa Lapitz, M. Laura Gutiérrez, Adelaida La La Casta, Cristina Alonso, Luis M. González, Matias A. Avila, Maria L. Martinez-Chantar, Rui E. Castro, Luis Bujanda, Jesus M. Banales, Jose J. G. Marin Published in: Cancers, Issue 12/6, 2020, Page(s) 1433, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12061433 Current and New Biomarkers for Early Detection, Prognostic Stratification, and Management of Gallbladder Cancer Patients Author(s): Patricia García, Angela Lamarca, Javier Díaz, Enrique Carrera, Juan Roa Published in: Cancers, Issue 12/12, 2020, Page(s) 3670, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12123670 Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer Author(s): Pérez-Moreno P, Riquelme I, García P, Brebi P, Roa JC. Published in: Journal of Personalized Medicine, 2022, ISSN 2075-4426 Publisher: MDPI DOI: 10.3390/jpm12020234 Cholangiocarcinoma 2020: the next horizon in mechanisms and management Author(s): Jesus M. Banales, Jose J. G. Marin, Angela Lamarca, Pedro M. Rodrigues, Shahid A. Khan, Lewis R. Roberts, Vincenzo Cardinale, Guido Carpino, Jesper B. Andersen, Chiara Braconi, Diego F. Calvisi, Maria J. Perugorria, Luca Fabris, Luke Boulter, Rocio I. R. Macias, Eugenio Gaudio, Domenico Alvaro, Sergio A. Gradilone, Mario Strazzabosco, Marco Marzioni, Cédric Coulouarn, Laura Fouassier, Chiara Ragg Published in: Nature Reviews Gastroenterology & Hepatology, Issue 17/9, 2020, Page(s) 557-588, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/s41575-020-0310-z Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology Author(s): Chimaobi M. Anugwom, Manon Allaire, Sheikh Mohammad Fazle Akbar, Amir Sultan, Steven Bollipo, Angelo Z. Mattos, Jose D. Debes Published in: Hepatoma Research, 2021, ISSN 2454-2520 Publisher: OAE publishing DOI: 10.20517/2394-5079.2021.06 Role of lncRNAs in the development of an aggressive phenotype in gallbladder cancer Author(s): Pablo Pérez-Moreno, Ismael Riquelme, Priscilla Brebi, Juan Carlos Roa Published in: Journal of Clinical Medicine, 2021, ISSN 2077-0383 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/jcm10184206 Ivosidenib: an investigational drug for the treatment of biliary tract cancers Author(s): Angelos Angelakas, Angela Lamarca, Richard a Hubner, Mairéad G McNamara, Juan W. Valle Published in: Expert Opinion on Investigational Drugs, Issue 30/4, 2021, Page(s) 301-307, ISSN 1354-3784 Publisher: Ashley Publications Ltd. DOI: 10.1080/13543784.2021.1900115 Druggable molecular alterations in bile duct cancer: potential and current therapeutic applications in clinical trials. Author(s): Héloïse Bourien, Angela Lamarca, Mairéad G McNamara, Richard A Hubner, Juan W Valle, Julien Edeline Published in: Expert Opinion on Investigational Drugs, 2021, ISSN 1354-3784 Publisher: Ashley Publications Ltd. DOI: 10.1080/13543784.2021.1964470 Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation Author(s): Sabine K. Urban, Hanna Sänger, Marcin Krawczyk, Henrike Julich‐Haertel, Arnulf Willms, Joanna Ligocka, Mikel Azkargorta, Tudor Mocan, Christoph Kahlert, Beata Kruk, Krzysztof Jankowski, Waldemar Patkowski, Marek Krawczyk, Krzysztof Zieniewicz, Wacław Hołówko, Łukasz Krupa, Mateusz Rzucidło, Krzysztof Gutkowski, Wojciech Wystrychowski, Robert Król, Joanna Raszeja‐Wyszomirska, Artur Słom Published in: Liver International, Issue 40/12, 2020, Page(s) 3103-3116, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.14585 Locoregional therapies in patients with intrahepatic cholangiocarcinoma: a systematic review and pooled analysis. Author(s): Julien Edeline, Angela Lamarca, Mairéad G McNamara, Timothy Jacobs, Richard A Hubner, Dan Palmer, Bas Groot Koerkamp, Philip Johnson, Boris Guiu and Juan W Valle. Published in: Cancer Treatment reviews, 2021, ISSN 0305-7372 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.ctrv.2021.102258 Dysplasia and carcinoma of the gallbladder: pathological evaluation, sampling, differential diagnosis and clinical implications Author(s): Juan C Roa, Olca Basturk, Volkan Adsay Published in: Histopathology, 2022, ISSN 1365-2559 Publisher: Wiley DOI: 10.1111/his.14360 Advances in systemic therapy for the first-line treatment of unresectable HCC Author(s): Arndt Vogel, Melanie Bathon, Anna Saborowski Published in: Expert Review of Anticancer Therapy, 2021, ISSN 1473-7140 Publisher: Future Drugs Ltd. DOI: 10.1080/14737140.2021.1882855 Non-alcoholic fatty liver disease-related hepatocellular carcinoma: Is there a role for immunotherapy? Author(s): Ângelo Z Mattos, Jose D Debes, Arndt Vogel, Marco Arrese, Xavier Revelo, Tales Henrique S Pase, Muriel Manica, Angelo A Mattos Published in: World Journal of Gastroenterology, 2022, ISSN 2219-2840 Publisher: Baishideng Publishing Group DOI: 10.3748/wjg.v28.i28.3595 Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America Author(s): Balderramo D, Mattos AZ, Mulqui V, Chiesa T, Plácido-Damián Z, Abarca J, Bolomo A, Carlino Y, Bombassaro IZ, Wiltgen D, Castillo LT, Díaz K, Acuña J, Manero E, Prieto J, Carrera E, Díaz-Ferrer J, Debes JD Published in: Can J Gastroenterol Hepatol, 2021, ISSN 2291-2789 Publisher: Pulsus Group Inc. DOI: 10.1155/2021/1622533 Hepatocellular carcinoma Author(s): Arndt Vogel, Tim Meyer, Gonzalo Sapisochin, Riad Salem, Anna Saborowski Published in: The lancet, 2022, ISSN 0140-6736 Publisher: The Lancet Publishing Group DOI: 10.1016/s0140-6736(22)01200-4 Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry. Author(s): Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborow Published in: J Hepatol., 2022, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2021.12.010 PIGR-enriched circulating vesicles contributes to hepatocellular carcinoma aggressiveness Author(s): Zingoni A, Banales JM. Published in: J Hepatol., 2022, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2022.02.001 Insights into NAFLD heterogeneity Author(s): Marco Arrese, MD, Juan Pablo Arab, MD, Francisco Barrera, MD, Ben Kaufmann, MD, Luca Valenti; MD, PhD, Ariel E. Feldstein, MD Published in: Seminars in Liver Disease, 2021, ISSN 1098-8971 Publisher: Thieme DOI: 10.1055/s-0041-1730927 Implicit bias in region-dependent publication potential can partly be counteracted by Academic collaboration Author(s): Maikel P. Peppelenbosch, Carmen V. Ferreira Published in: Clinical Gastroenterology and Hepatology, 2021, ISSN 1542-3565 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.cgh.2021.04.001 Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up Author(s): Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M Published in: Annals of Oncology, 2022, ISSN 0923-7534 Publisher: Oxford University Press DOI: 10.1016/j.annonc.2022.10.506 Current impact of viral hepatitis on liver cancer development: The challenge remains Author(s): """Ângelo Zambam de Mattos, Jose D Debes, Andre Boonstra, Ju-Dong Yang, Domingo C Balderramo, Giovana D P Sartori, Angelo Alves de Mattos""" Published in: World J Gastroenterol, 2021, ISSN 1007-9327 Publisher: W J G Press DOI: 10.3748/wjg.v27.i24.3556 Reply to “Does multiple intrahepatic cholangiocarcinoma worsen prognosis as “M1” stage?”; multiple primaries vs liver metastases Author(s): Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle Published in: Hepatology, 2021, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.31740 Understanding immune perspectives and options for the use of checkpoint immunotherapy in HCC post liver transplant Author(s): Chimaobi M Anugwom, Thomas M Leventhal, Jose D Debes Published in: Hepatoma research, 2022, ISSN 2454-2520 Publisher: OAE Publishing Inc. DOI: 10.20517/2394-5079.2021.123 Hepatobiliary cancers in South America: disparity strikes Author(s): Jose D Debes, Andre Boonstra, Domingo Balderramo, Angelo Z Mattos, Marco Arrese, Juan C. Roa, Juan W. Valle, Jesus M. Banales, Enrique Carrera, Pablo A. Romagnoli, Jhon E. Prieto, Bettina E. Hansen, Arndt Vogel, Angela Lamarca Published in: The Lancet Gastroenterology & Hepatology, Issue 4/8, 2019, Page(s) 581, ISSN 2468-1253 Publisher: Elsevier DOI: 10.1016/s2468-1253(19)30188-8 Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis Author(s): Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz-Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez-Arranz, Ainhoa Lapitz, Alvaro Santos-Laso, Matias A. Avila, Maria L. Martínez-Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias Published in: Hepatology, Issue 70/2, 2019, Page(s) 547-562, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.30319 Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor Author(s): Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Dávila-López, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato, Pamela Leal, Marcela Lagos, Juan Carlos Roa Published in: Biological Research, Issue 53/1, 2020, ISSN 0717-6287 Publisher: Biological Research (BMC) DOI: 10.1186/s40659-020-00282-7 Hepatocellular Carcinoma: Unraveling the Role of Occult Hepatitis B Virus Infection Author(s): Ângelo Z. Mattos, Angelo A. Mattos, Jose D. Debes Published in: Clinical Gastroenterology and Hepatology, 2020, ISSN 1542-3565 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.cgh.2020.03.028 Diagnostic and prognostic biomarkers in cholangiocarcinoma Author(s): Rocio I. R. Macias, Miroslaw Kornek, Pedro M. Rodrigues, Nuno A. Paiva, Rui E. Castro, Sabine Urban, Stephen P. Pereira, Massimiliano Cadamuro, Christian Rupp, Sven H. Loosen, Tom Luedde, Jesus M. Banales Published in: Liver International, Issue 39/S1, 2019, Page(s) 108-122, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.14090 Hepatocellular carcinoma, a unique tumor with a lack of biomarkers Author(s): Jose D. Debes, Enrique Carrera, Angelo Z. Mattos, Jhon E. Prieto, Andre Boonstra Published in: Annals of Hepatology, Issue 18/6, 2019, Page(s) 786-787, ISSN 1665-2681 Publisher: Ediciones Medicina y Cultura DOI: 10.1016/j.aohep.2019.07.009 Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer Author(s): Patricia García, Lorena Rosa, Sergio Vargas, Helga Weber, Jaime A. Espinoza, Felipe Suárez, Isabel Romero-Calvo, Nicole Elgueta, Vanessa Rivera, Bruno Nervi, Javiera Obreque, Pamela Leal, Eduardo Viñuela, Gloria Aguayo, Sabrina Muñiz, Alfredo Sagredo, Juan C. Roa, Carolina Bizama Published in: Cancers, Issue 12/4, 2020, Page(s) 778, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12040778 NAFLD‐Related Hepatocellular Carcinoma and the Four Horsemen of the Apocalypse Author(s): Jose D. Debes, Andre Boonstra, Robert J. Knegt Published in: Hepatology, Issue 71/3, 2020, Page(s) 774-776, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.31170 Circulating biomarkers for early detection of hepatocellular carcinoma Author(s): Boris J. B. Beudeker, Andre Boonstra Published in: Therapeutic Advances in Gastroenterology, Issue 13, 2020, Page(s) 175628482093173, ISSN 1756-2848 Publisher: SAGE DOI: 10.1177/1756284820931734 Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience. Author(s): Welland S, deCastro T, Bathon M, Wirth TC, Reineke-Plaaß T, Saborowski M, Lehmann U, Saborowski A, Vogel A. Published in: Journal of Cancer Research and Clinical Oncology, 2021, ISSN 0171-5216 Publisher: Springer Verlag DOI: 10.1007/s00432-021-03774-5 Targeted therapies for Perihilar Cholangiocarcinoma Author(s): Simon Gray, Angela Lamarca, Julien Edeline, Heinz-Josef Klümpen, Richard A. Hubner, Mairéad G. McNamara, Juan W. Valle Published in: Cancers (Basel), Issue 14(7), 2022, Page(s) 1789, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14071789 Immune aspects of hepatocellular carcinoma: From immune markers for early detection to immunotherapy Author(s): Mattos ÂZ, Debes JD, Boonstra A, Vogel A, Mattos AA Published in: World Journal of Gastrointestinal Oncology, 2021, ISSN 1948-5204 Publisher: Baishideng Publishing Group DOI: 10.4251/wjgo.v13.i9.1132 Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands. Author(s): Beudeker BJB, Voermans JJC, Geurtsvankessel CH, de Knegt RJ, Kuhlemann T, Boonstra A, van der Eijk AA Published in: Journal of Clinical Virology, 2021, ISSN 1386-6532 Publisher: Elsevier BV DOI: 10.1016/j.jcv.2021.104870 Surgery for advanced intrahepatic cholangiocarcinoma warrants further investigation Author(s): Angela Lamarca, Alvaro Santos-Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle Published in: Hepatology, 2021, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.31904 Gallbladder cancer Author(s): Juan C. Roa, Patricia García, Vinay K. Kapoor, Shishir K. Maithel, Milind Javle & Jill Koshiol Published in: Nature Review Disease Primers, 2022, ISSN 2056-676X Publisher: Springer nature DOI: 10.1038/s41572-022-00408-z Current and Future Systemic Therapies in Biliary Tract Cancer Author(s): Arndt Vogel, Anna Saborowski Published in: Visceral Medicine, Issue 37/1, 2021, Page(s) 32-38, ISSN 2297-4725 Publisher: Karger international DOI: 10.1159/000513969 Immunotherapies in clinical development for biliary tract cancer Author(s): Arndt Vogel, Melanie Bathon, Anna Saborowski Published in: Expert Opinion on Investigational Drugs, Issue 30/4, 2021, Page(s) 351-363, ISSN 1354-3784 Publisher: Ashley Publications Ltd. DOI: 10.1080/13543784.2021.1868437 Changing epidemiology of hepatocellular carcinoma in South America: a report from the South American Liver Research Network Author(s): Marina Faraha, Chimaobi Anugwomb, Javier Diaz Ferrerc, Estefania Liza Bacac, Angelo Z. Mattosd, João Pedro P. Possebond, Marco Arresee, Jhon Prietof, Domingo Balderramog, Enrique Carrerah, Jose D. Debes Published in: Annals of Hepatology, 2022, ISSN 1665-2681 Publisher: Ediciones Medicina y Cultura DOI: 10.1016/j.aohep.2022.100876 The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma Author(s): Noe Rico Montanari, Chimaobi M. Anugwom, Andre Boonstra and Jose D. Debes Published in: Cancers, 2021, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13194876 Pathogenesis of Cholangiocarcinoma Author(s): Pedro M. Rodrigues, Paula Olaizola, Nuno A. Paiva, Irene Olaizola, Alona Agirre-Lizaso, Ana Landa, Luis Bujanda, Maria J. Perugorria, Jesus M. Banales Published in: Annual Review of Pathology: Mechanisms of Disease, Issue 16/1, 2021, Page(s) 433-463, ISSN 1553-4006 Publisher: Annual Reviews, Inc. DOI: 10.1146/annurev-pathol-030220-020455 Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic Author(s): Massimiliano Cadamuro, Alberto Lasagni, Angela Lamarca, Laura Fouassier, Maria Guido, Samantha Sarcognato, Enrico Gringeri, Umberto Cillo, Mario Strazzabosco, Jose JG Marin, Jesus M Banales, Luca Fabris Published in: Expert Opinion on Investigational Drugs, Issue 30/4, 2021, Page(s) 377-388, ISSN 1354-3784 Publisher: Ashley Publications Ltd. DOI: 10.1080/13543784.2021.1880564 Serum Biomarkers for the Prediction of Hepatocellular Carcinoma Author(s): José Debes, Pablo Romagnoli, Jhon Prieto, Marco Arrese, Angelo Mattos, André Boonstra Published in: Cancers, Issue 13/7, 2021, Page(s) 1681, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13071681 New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming Author(s): Colyn L, Alvarez-Sola G, Latasa MU, Uriarte I, Herranz JM, Arechederra M, Vlachogiannis G, Rae C, Pineda-Lucena A, Casadei-Gardini A, Pedica F, Aldrighetti L, López-López A, López-Gonzálvez A, Barbas C, Ciordia S, Van Liempd SM, Falcón-Pérez JM, Urman J, Sangro B, Vicent S, Iraburu MJ, Prosper F, Nelson LJ, Banales JM, Martinez-Chantar ML, Marin JJG, Braconi C, Trautwein C, Corrales FJ, Cub Published in: J Exp Clin Cancer Res., 2022, ISSN 1756-9966 Publisher: BioMed Central DOI: 10.1186/s13046-022-02386-2 Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry Author(s): Nooijen LE, Banales JM, de Boer MT, Braconi C, Folseraas T, Forner A, Holowko W, Hoogwater FJH, Klümpen HJ, Groot Koerkamp B, Lamarca A, La Casta A, López-López F, Izquierdo-Sánchez L, Scheiter A, Utpatel K, Swijnenburg RJ, Kazemier G, Erdmann JI; ENSCCA Group. Published in: Cancers (Basel), 2022, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14102389 Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis Author(s): Ainhoa Lapitz, Ander Arbelaiz, Colm J. O’Rourke, Jose L. Lavin, Adelaida La Casta, Cesar Ibarra, Juan P. Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Marcin Krawczyk, Maria J. Perugorria, Raul Jimenez-Aguero, Alberto Sanchez-Campos, Ioana Riaño, Esperanza Gónzalez, Frank Lammert, Marco Marzioni, Rocio I.R. Macias, Jose J. G. Marin, Tom H. Karlsen, Luis Bujanda, Juan M. Falcón-Pérez, Published in: Cells, Issue 9/3, 2020, Page(s) 721, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells9030721 Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management Author(s): Amedeo Lonardo, Juan Pablo Arab, Marco Arrese Published in: Advances in Therapy, 2021, ISSN 0741-238X Publisher: Health Communications, Inc. DOI: 10.1007/s12325-021-01690-1 Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach Author(s): Jesús M. Urman, José M. Herranz, Iker Uriarte, María Rullán, Daniel Oyón, Belén González, Ignacio Fernandez-Urién, Juan Carrascosa, Federico Bolado, Lucía Zabalza, María Arechederra, Gloria Alvarez-Sola, Leticia Colyn, María U. Latasa, Leonor Puchades-Carrasco, Antonio Pineda-Lucena, María J. Iraburu, Marta Iruarrizaga-Lejarreta, Cristina Alonso, Bruno Sangro, Ana Purroy, Isabel Gil, L Published in: Cancers, Issue 12/6, 2020, Page(s) 1644, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12061644 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
