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PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Deliverables

Update on communication and dissemination activities

Update on communication and dissemination activities for different stakeholders, including patients

Dissemination and Communication Plan

Dissemination and Communication Plan, including timely open access publication of results (green or gold OA) and other dissemination activities (including via project website)

Data management & sharing plan (DMSP) - Interim

Data management & sharing plan (DMSP) - Interim

Data management & sharing plan (DMSP) - Initial

Data management & sharing plan (DMSP) - Initial veresion

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Publications

Phenomenological equations for electron transport chain-mediated reactive oxygen species metabolism

Author(s): Prof. Jochen Prehn, Dr Niamh Connolly and Sandeep Chenna
Published in: 2021 IEEE International Conference on Bioinformatics and Biomedicine, 2021, 2021, Page(s) pp. 653-658
Publisher: IEEE
DOI: 10.1109/bibm52615.2021.9669351

Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

Author(s): Céline Galvagnion, Frederik Ravnkilde Marlet, Silvia Cerri, Anthony H V Schapira, Fabio Blandini, Donato A Di Monte
Published in: Brain Communications, 2022, ISSN 2632-1297
Publisher: Oxford University Press
DOI: 10.1093/brain/awab371

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Author(s): Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V. Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T. Heneka
Published in: Cell, 184/20, 2021, Page(s) 5089-5106.e21, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.09.007

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Author(s): Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, DeboraGentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, KristianHändler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Published in: Molecular Metabolism, 19 April 2022, 2022, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101503

CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants

Author(s): Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gomez Martın, Fabio Bertan, Chester J J Wrobel, Frank C Schroeder, Dan Ehninger, Kristian H€andler, Joachim L Schultze, Lukas Schreiber, Gerhild van Echten-Deckert, Pierluigi Nicotera & Daniele Bano
Published in: EMBO Reports, e52606, 2022, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202152606

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Author(s): Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Published in: Journal of Neurochemistry, Volume150, Issue5 Special Issue: Synuclein Meeting 2019, 2019, Page(s) 522-534, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

Author(s): M. Jacoupy, E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti
Published in: Scientific Reports, 9/1, 2019, Page(s) 1-15, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-47352-9

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Author(s): Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Published in: Acta Neuropathologica Communications, 7/1, 2019, Page(s) 1-18, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-019-0859-3

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Author(s): Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Published in: Biophysical Journal, 27 January 2020, 2020, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Author(s): Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Author(s): Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Published in: Biochemical and Biophysical Research Communications, 17 May 2020, 2020, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

Author(s): Orla Watters, Niamh M. C. Connolly, Hans-Georg König, Heiko Düssmann, Jochen H. M. Prehn
Published in: The Journal of Neuroscience, 11 May 2020, 2020, Page(s) JN-RM-2067-19, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2067-19.2020

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition

Author(s): Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Published in: Cell Death & Disease, 12/5, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03742-4

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

Author(s): Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot and Patrick P. Michel
Published in: Cells, 2022, 11, 1640, 2022, ISSN 2073-4409
Publisher: Molecular Diversity Preservation International
DOI: 10.3390/cells11101640

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Author(s): Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Published in: Journal of Biological Chemistry, 2021, 2021, Page(s) 100737, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737