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The regulatory GENomE of SWine and CHicken: functional annotation during development

Objective

GENE-SWitCH aims to deliver new underpinning knowledge on the functional genomes of two main monogastric farm species (pig and chicken) and to enable immediate translation to the pig and poultry sectors. The activation status of functional genome sequences varies across time and space, and in response to environmental perturbations. In full coordination and synergy with global effort and ongoing projects of the Functional Annotation of ANimal Genomes (FAANG) community, we will characterize the dynamics (“switches”) of the functional genome from embryo (chicken) and fetus (pig) to adult life by targeting a panel of tissues relevant to sustainable production. New expression QTL data in pigs and existing high-resolution QTL data in chicken will be used for developing innovative genomic predictive models that integrate functional annotations, and these models will be validated in commercial pig and poultry populations. In addition, nutritional epigenetic data will allow evaluation of the influence of maternal diet on the epigenome of the pig fetus and whether such effects persist until post-weaning. These open-shared datasets will conform fully with FAANG standards and add valuable knowledge on genetic and epigenetic variation of functional elements to FAANG. A comprehensive plan of dissemination and outreach activities to a large audience of stakeholders will be implemented. The GENE-SWitCH consortium brings together partners representing pan-European excellence (including the academic institutions which pioneered FAANG) and world-leading animal breeding and biotech industry in a true co-creation effort. Overall, GENE-SWitCH will contribute to the global FAANG effort considerably, demonstrate how functional annotation of genomes can foster the advancement of genomic selection for immediate benefit to the breeding industry, and produce cutting-edge research paving the way to new studies and strategies for sustainable productions.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /natural sciences/biological sciences/genetics and heredity/epigenetics
  • /medical and health sciences/clinical medicine/embryology

Call for proposal

H2020-SFS-2018-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Address
147 Rue De L'universite
75007 Paris Cedex 07
France
Activity type
Research Organisations
EU contribution
€ 1 195 073

Participants (10)

INRAE TRANSFERT SAS
France
EU contribution
€ 209 750
Address
Rue Du Docteur Finlay 28
75015 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 905 523
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 971 783
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 710 478
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 287 500
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
DIAGENODE
Belgium
EU contribution
€ 548 000
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROPEAN FORUM OF FARM ANIMAL BREEDERS
Netherlands
EU contribution
€ 197 357
Address
Silkeborg 75
2905 AT Capelle Aan Den Ijssel
Activity type
Research Organisations
FEDERAZIONE EUROPEA DI ZOOTECNICA
Italy
EU contribution
€ 120 687
Address
Via Giuseppe Tomassetti 3 A/1
00161 Roma
Activity type
Other
HENDRIX GENETICS RESEARCH,TECHNOLOGY & SERVICES BV
Netherlands
EU contribution
€ 343 743
Address
Spoorstraat 69
5831 CK Boxmeer
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES
Spain
EU contribution
€ 509 992
Address
Ctra C-59 Km 12 Torre Marimon
08140 Caldes De Montbui Barcelona
Activity type
Other