Objective
GENE-SWitCH aims to deliver new underpinning knowledge on the functional genomes of two main monogastric farm species (pig and chicken) and to enable immediate translation to the pig and poultry sectors. The activation status of functional genome sequences varies across time and space, and in response to environmental perturbations. In full coordination and synergy with global effort and ongoing projects of the Functional Annotation of ANimal Genomes (FAANG) community, we will characterize the dynamics (“switches”) of the functional genome from embryo (chicken) and fetus (pig) to adult life by targeting a panel of tissues relevant to sustainable production. New expression QTL data in pigs and existing high-resolution QTL data in chicken will be used for developing innovative genomic predictive models that integrate functional annotations, and these models will be validated in commercial pig and poultry populations. In addition, nutritional epigenetic data will allow evaluation of the influence of maternal diet on the epigenome of the pig fetus and whether such effects persist until post-weaning. These open-shared datasets will conform fully with FAANG standards and add valuable knowledge on genetic and epigenetic variation of functional elements to FAANG. A comprehensive plan of dissemination and outreach activities to a large audience of stakeholders will be implemented. The GENE-SWitCH consortium brings together partners representing pan-European excellence (including the academic institutions which pioneered FAANG) and world-leading animal breeding and biotech industry in a true co-creation effort. Overall, GENE-SWitCH will contribute to the global FAANG effort considerably, demonstrate how functional annotation of genomes can foster the advancement of genomic selection for immediate benefit to the breeding industry, and produce cutting-edge research paving the way to new studies and strategies for sustainable productions.
Field of science
- /natural sciences/biological sciences/genetics and heredity/genome
- /natural sciences/biological sciences/genetics and heredity/epigenetics
- /medical and health sciences/clinical medicine/embryology
Programme(s)
Call for proposal
H2020-SFS-2018-2
See other projects for this call
Funding Scheme
RIA - Research and Innovation actionCoordinator
75007 Paris Cedex 07
France
Participants (10)
75015 Paris
EH8 9YL Edinburgh
6708 PB Wageningen
69117 Heidelberg
751 05 Uppsala
4102 Seraing
2905 AT Capelle Aan Den Ijssel
00161 Roma
5831 CK Boxmeer
08140 Caldes De Montbui Barcelona
