CORDIS
EU research results

CORDIS

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Monitoring multidimensional aspects of QUAlity of Life after cancer ImmunoTherapy - an Open smart digital Platform for personalized prevention and patient management

Project information

Grant agreement ID: 875171

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.5.1.

H2020-EU.3.1.3.2.

  • Overall budget:

    € 5 196 772,50

  • EU contribution

    € 5 196 772,50

Coordinated by:

HOSPICES CIVILS DE LYON

France

Objective

"Cancer immunotherapy brought about significant progress in cancer treatment. It resulted in high efficacy in some cancers; e.g., up to 60% objective response rate in melanoma and 80% complete response rate in acute lymphoblastic leukaemia. Nevertheless, two main challenges still impede improving cancer patients’ health status and quality of life (QoL) after immunotherapy initiation: 1) a crucial need for “predictive markers” of occurrence of immunotherapy-related adverse events (IR-AEs) to predict and improve patients’ health status and promote their QoL; and, 2) the lack of knowledge on patients after start of immunotherapy outside randomised controlled trials. To reach these goals, significantly more diversified sources of data are required.
Project QUALITOP aims at developing a European immunotherapy-specific open Smart Digital Platform and using big data analysis, artificial intelligence, and simulation modelling approaches. This will enable collecting and aggregating efficiently real-world data to monitor health status and QoL of cancer patients given immunotherapy. Through causal inference analyses, QUALITOP will identify the determinants of health status regarding IR-AEs and define patient profiles in a real-world context. For this, heterogeneous data sources (big data), both retrospective and prospective --collected for QUALITOP from clinical centres in four EU countries—will integrate lifestyle, genetic, and psychosocial determinants of QoL. Using machine learning approaches, QUALITOP will provide ""real-time"" recommendations stemming from patient profiles and feedbacks via the Smart Digital Platform. Furthermore, an increased visibility on patients’ behaviour, a better IR-AEs prediction, and an improvement of care coordination will help analysing through simulation modelling approaches the gain in cost-effectiveness. Guidelines will be issued over the short and long-term.
"

Coordinator

HOSPICES CIVILS DE LYON

Address

Quai Des Celestins 3
69002 Lyon

France

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

EU Contribution

€ 889 375

Participants (13)

UNIVERSITE LYON 1 CLAUDE BERNARD

France

EU Contribution

€ 406 125

UNIVERSITE LUMIERE LYON 2

France

EU Contribution

€ 352 681,25

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON

France

EU Contribution

€ 71 625

INSTITUTO PORTUGUES DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL EPE

Portugal

EU Contribution

€ 184 325

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 354 972,50

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 356 557,50

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom

EU Contribution

€ 567 395

SCIENTIFIC ACADEMY FOR SERVICE TECHNOLOGY EV

Germany

EU Contribution

€ 496 625

EUROPEAN CANCER PATIENT COALITION

Belgium

EU Contribution

€ 272 625

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 356 750

THE GENERAL HOSPITAL CORPORATION

United States

EU Contribution

€ 457 966,25

UNIVERSITA DELLA CALABRIA

Italy

EU Contribution

€ 278 500

LYON INGENIERIE PROJETS

France

EU Contribution

€ 151 250

Project information

Grant agreement ID: 875171

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.5.1.

H2020-EU.3.1.3.2.

  • Overall budget:

    € 5 196 772,50

  • EU contribution

    € 5 196 772,50

Coordinated by:

HOSPICES CIVILS DE LYON

France