Project description
Working against protein oxidation in milk
Protein oxidation during processing or storage negatively affects the quality of milk, often with deleterious effects on human health. The EU-funded CASMOX project is investigating the degradation pathway of caseins, the most abundant milk proteins, under conventional processing conditions. Using various analytical and biochemical methods, scientists are focussing on the nutritional consequences of milk protein oxidation and its biological effects such as toxicity and digestibility. Considering the high nutritional value and consumption of milk, the project's results will help improve existing industrial processing methods and develop more stringent policies for testing the quality of dairy products.
Objective
Oxidative damage is a major problem for dairy industry as it can occur to a significant extent during the processing and/or
storage of milk, and results in significant wastage. Due the high abundance of proteins, ~30% of the dry mass of whole milk,
these represent one of the most abundant targets of damage. Protein oxidation can have a direct impact on the nutritional
value of milk and the consumption of highly oxidised proteins may have deleterious consequences for human health. This
project will provide an improved understanding of the degradation pathways of the most abundant milk proteins (caseins),
the micelle structures that these proteins form, and the key drivers of these reactions. To address these aims, this project
will: (1) investigate the oxidation of casein micelle (CM) mediated by the most relevant oxidative sources generated during
milk processing and storage, and (2) determine the consequences of CM oxidation on their nutritional value (i.e. loss of
parent amino acids) and the biological effects (i.e. decreased digestibility, toxicity to human cells). The approaches to be
used in this project include analytical, biochemical and biological techniques (i.e. liquid chromatography, SDS-PAGE,
western blotting, mass spectrometry, electron microscopy, cell culture models). The project is of interest to the European
community as milk and dairy products represent one of the most consumed food materials, with health and nutrition claims
for these products based on the presence of specific materials, such as proteins. It is therefore critically important that these
claims are justified and correct. This project will provide important new knowledge, as there are currently no data available
as to the pathways responsible for CM oxidative modifications. Such data is a pre-requisite to the development of lessharmful
industrial milk processing methods. The project will also validate new methods to examine the nutritional quality of
milk and dairy products.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences chemical sciences organic chemistry amines
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.