Project description
Nanotechnology-based treatment for alopecia
Alopecia areata (AA) is an autoimmune disorder associated with patchy hair loss that results from T cells attacking the hair follicles. Conventional treatment employs the use of topical corticosteroids, which, however, do not provide a cure. The EU-funded EngiNano-HF project is interested to develop novel treatment solutions for AA using nanocarriers that facilitate the controlled release of therapeutic substances. Researchers will develop a series of polymer nanoformulations and characterise their properties alongside their capacity to penetrate hair follicles and achieve targeted delivery. Results have the potential to improve existing treatment options for AA.
Objective
Alopecia areata (AA) is a common autoimmune disorder resulting from damage of the hair follicle by cytotoxic T cells and characterized by non-scarring hair loss. This project intended for preventive treatment AA brings together a highly motivated, experienced, and talented Researcher (Dr. Matías Picchio), with a Polymer Chemistry background in biomaterials, hydrogels, and nanoparticle synthesis and properties improvement methodologies for biomedical applications, and POLYMAT, an innovative technological institute in the field of development of biomedical solutions based on nanohydrogels for the controlled release of therapeutic substances. EngiNano-HF will focus on advancing the Experienced Researcher’s career through the development of the technology and manufacture stages of a new supramolecular polymer nanoformulation for the successful management of Janus kinase-inhibitors to prevent AA and associated complications. Under the supervision of Prof. M. Calderón, a globally recognized researcher, EngiNano-HF will proceed in a stepwise fashion using cutting-edge methodologies to prepare and physicochemically characterize the polymer nanocarriers. The effect of the nanocarrier size, surface chemistry, surface charge, and mechanical properties on the hair follicle penetration and follicular delivery will be evaluated in porcine ear skin ex-vivo models. The most promising formulations will then be validated on a pre-industrial scale. Three highly experienced teams RPT, CRC, and i+Med company will complement each other to meet the multidisciplinary expertise needed for EngiNano-HF. This proposal is designed to allow the applicant to expand his research field significantly by receiving high-quality training-through-research and developing a new set of transferable skills. Moreover, with the aim of achieving the highest possible social, industrial, and academic impact, this proposal covers multiple aspects related to exploitation, dissemination, and outreach activities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences polymer sciences
- engineering and technology nanotechnology nano-materials
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48940 Leioa
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.