Project description
Nanomaterials to replace antibodies in cancer screening
Histo-pathology is the tool of choice for reliable diagnosis of many cancers. In most cases, pathologists also need to test a high number of biomarkers on a given tumour for better diagnostic and adapted treatments. Today, biomarker analyses are sequential and require several biopsy slices implying not always available biological material. Testing several biomarkers in an efficient, quantitative and reproducible way on a single tissue biopsy slice, is key. To address this technical challenge, the EU-funded Multi-IF project aims to generate novel fluorescent biomarkers based on carbon nanotubes. Researchers will also develop a new microscope capable of detecting multiplex immunofluorescence on a single biopsy. Project deliverables will significantly advance existing cancer diagnosis approaches.
Objective
Multi-IF proposes a fully innovative approach combining nanoscience, fluorescence microscopy and cancer histopathology to achieve optically multiplexed immunofluorescence for cancer diagnostic. At present, when examining cancer tissue, biomarker analyses are sequential and require several biopsy slices implying a lot of (not always available) biological material. Testing several biomarkers on a single tissue biopsy slice in an efficient, quantitative and reproducible way, would be crucial but not currently available at hospital. This project will involve an innovative technology based on single-walled carbon nanotubes to create a library of novel multicolor immuno-labels. More precisely, this will employ sp3 defects implanted fluorescent ultrashort nanotubes together with the development of a dedicated NIR microscope for multiplexed immunofluorescence on a single biopsy and the proof-of-concept on liver cancer tissue. The applicant will bring strong expertise in chemical synthesis, bioprobe spectroscopy and time-resolved fluorescence microscopy applied to the study of complex and heterogeneous bio-molecular organization (2D/3D cells, proteins and peptides). Concomitantly, he will gain a high-level hands-on training on carbon nanotube optics, near-infrared advanced spectroscopy, custom-built microscopy techniques, cancer tissue model and imaging analysis. To achieve this objective, the project will be performed at one of the leading French research institution, IOGS-LP2N at the CNRS/Univ. Bordeaux, with well-identified work packages to ensure efficient management, career development and training, science development, communication and technology transfer to pathologists. It will allow the applicant to reach high level of professional maturity to develop independent research career. The fellow’s expertise, privileged environment of the hosting lab, the mentoring, the infrastructure & relevant facilities will guarantee the successful execution of Multi-IF goals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology liver cancer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- natural sciences physical sciences optics spectroscopy
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91120 Palaiseau
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.