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Data-driven cancer genome interpretation for personalised cancer treatment

Objective

CGI-Clinics aims at improving personalised medicine in oncology by optimizing genomic data interpretation (after sequencing and before advising on compatible targeted therapies). Interpretation is a bottleneck for the full deployment and broad accessibility of Next Generation Sequencing (NGS) in cancer management. The project tackles the 3 main hurdles in the interpretation of cancer mutations: it is not systematic, it deals with a majority of variants of unknown significance and it fails to empower patients.

The interpretation of tumor genomic data relies on the work of experts reviewing scattered databases and resources, in a time-consuming process that may lead to suboptimal clinical decisions. CGI-clinics will systematize the interpretation process by integrating relevant public and private databases hospitals in a one-stop shop tool, with the possibility to organize virtual molecular tumor boards co-facilitated by reference hospitals. Project will have three phases: a setup (assess needs), validation (pilot with the 9 clinical partners) and replication (30 hospitals across EU). It will enable democratization of genomic data interpretation (independent of their size, resources and profiling technology) and provide health economics validation.

Relying on a systematic automatic learning platform, GCI-Clinics will increase the share of interpretable variants in tumors (from the current 9-12% to at least 50%), and features that constitute biomarkers of drug response. The interpretation process is complex for most cancer patients, alienating them from knowledge of their illness. CGI-Clinics will build eduCGI, an app to help them understand the information gained through interpretation of their tumors, facilitating informed discussions with clinicians and sharing their data for research. Ultimately, the project is built to inform policy-makers on cancer management and empower patients.

Coordinator

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Net EU contribution
€ 2 872 675,00
Address
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00

Participants (14)

FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
Net EU contribution
€ 489 425,00
Address
Calle Nazaret 115-117
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
INSTITUT GUSTAVE ROUSSY
France
Net EU contribution
€ 379 305,00
Address
Rue Camille Desmoulins 39
94805 Villejuif

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Region
Ile-de-France Ile-de-France Val-de-Marne
Activity type
Research Organisations
Other funding
€ 0,00
CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD
France
Net EU contribution
€ 460 825,00
Address
Rue Laennec 28
69373 Lyon

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Research Organisations
Other funding
€ 0,00
EUROPEAN CANCER PATIENT COALITION
Belgium
Net EU contribution
€ 324 897,00
Address
Avenue Des Arts 6
1210 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Other funding
€ 0,50
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
Net EU contribution
€ 440 100,00
Address
Kerpener Strasse 62
50937 Koeln

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Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUNDACION CIENTIFICA DE LA ASOCIACIÓN ESPANOLA CONTRA EL CANCER
Spain
Net EU contribution
€ 466 813,00
Address
Teniente Coronel Norena 30
28045 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Other
Other funding
€ 0,75
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
Net EU contribution
€ 1 245 341,00
Address
Carrer Doctor Aiguader 88
08003 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,25
ALIRA HEALTH SL
Spain
Net EU contribution
€ 1 544 062,00
Address
Av Josep Tarradellas 132 Planta 7
08029 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,50
SERVICIO ANDALUZ DE SALUD
Spain
Net EU contribution
€ 193 096,00
Address
Avenida De La Constitucion 18
41071 Sevilla

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Region
Andalucía Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,25
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P.
Spain
Net EU contribution
€ 18 962,00
Address
Avenida Americo Vespucio 15 Edif S2
41092 Sevilla

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Region
Andalucía Sevilla
Activity type
Research Organisations
Other funding
€ 0,50
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE GIRONA DOCTOR JOSEP TRUETA
Spain
Net EU contribution
€ 218 975,00
Address
Calle Dr. Castany Sn Edificio De La Mancomunidad 2 Parque Hospitalario Marti Julia
17190 Girona

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Region
Este Cataluña Girona
Activity type
Research Organisations
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT CATALA D'ONCOLOGIA
Spain
Net EU contribution
€ 0,00
Address
Av Gran Via De L'hospitalet 199-203
08908 L'hospitalet Del Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
ALTHAIA XARXA ASSISTENCIAL UNIVERSITARIA DE MANRESA FUNDACIO PRIVADA
Spain
Net EU contribution
€ 216 432,00
Address
Calle Doctor Joan Soler 1-3
08243 Manresa Barcelona

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Region
Este Cataluña Barcelona
Activity type
Other
Other funding
€ 0,50
UNIVERSITAETSKLINIKUM AACHEN
Germany
Net EU contribution
€ 386 600,00
Address
Pauwelsstrasse 30
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Partners (2)

THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 0,00
Address
Oxford Road
M13 9PL Manchester

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Other funding
No data
EUROPEAN ASSOCIATION FOR CANCER RESEARCH
United Kingdom
Net EU contribution
€ 0,00
Address
Sir Colin Campbell Building, Triumph Road, University Of Notthingham, Innovation Park
NG7 2TU Nottingham

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Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
Activity type
Other
Other funding
No data