Project description
Improving stent design for better blood flow
When arteries become too narrow, doctors use stents (small mesh tubes) to keep them open and restore blood flow. However, stents create a rough surface inside the artery, which changes how blood moves. This can lead to unexpected flow patterns that may increase the risk of complications, such as the artery narrowing again (restenosis). Scientists do not understand how these changes affect blood flow and artery health. Supported by the Marie Skłodowska-Curie Actions programme, the CARE project will study how stents influence blood movement. Researchers will analyse how different stent designs create swirling currents inside arteries. The goal is to develop improved stents that promote healthy blood flow and reduce the risk of complications.
Objective
Stents are tub nets of varied materials and geometries that are installed in narrowed (stenotic) arteries to preserve their restored diameter following surgical procedure (e.g. angioplasty). Stents add a roughness element to the otherwise smooth walls of arteries, thus altering the hemodynamic environment and the flow characteristics. CARE is inspired by recent results in wall-bounded flows, which have shown that roughness patterns of height much smaller than the flow size may generate secondary currents (SCs), large-scale streamwise vortices (comparable to the artery diameter) that alter flow structure, transport mechanisms, wall shear stress distributions and flow drag, among others. Due to their geometrical properties, stents are ideal candidates for the generation of SCs within the flow, with potentially significant effects on biological processes, e.g. restenosis. CARE will aim at advancing our understanding of SC dynamics in arterial flows by assessing their effects on key hemodynamic parameters and analysing energy exchanges. General guidelines for improved stent designs that control and modulate SCs, by preventing or promoting their generation, will be outlined.
At present, roughness-induced SCs in stented arteries are largely unexplored, making the proposed research particularly timely. CARE will be based on laboratory experiments covering a range of flow conditions similar to those that can be found in the main body arteries. Different roughness patterns will be studied, including the reproduction of an actual stent. An advanced stereoscopic particle-image velocimetry system, capable of non-intrusive planar velocity measurements, will be used to study the SC patterns and their effects on wall shear stress distribution, as well as their contribution to momentum and energy exchanges.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery surgical procedures
- natural sciences mathematics pure mathematics geometry
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2022-PF-01
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35122 Padova
Italy
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