Project description
Unleashing arene oxidation via engineered unspecific peroxygenases
Direct epoxidation of arenes by cytochrome P450 is an important metabolic pathway in eukaryotes. The resulting arene oxides are also versatile precursors to many other classes of molecules. Despite this reaction’s tremendous potential for biotechnology applications, its replication has been elusive, hampering its exploitation. With the support of the Marie Skłodowska-Curie Actions programme, the UPOxArene project aims to achieve the epoxidation of arenes in a single step using engineered unspecific peroxygenases (UPOs). The researchers also plan to expand UPO chemistry beyond the aromatic hydroxylation accessible with cytochrome P450s by leveraging UPOs’ compatibility with organic media. The approach’s biotechnological relevance will be highlighted through production of industrially relevant compounds in continuous chemo-enzymatic cascades.
Objective
UPOXARENE is an interdisciplinary project combining organic synthesis, biocatalysis, and protein engineering, to realise the elusive epoxidation of arenes in a single step using engineered unspecific peroxygenases (UPOs). The compatibility of UPOs with organic media will be exploited to expand their chemistry beyond the aromatic hydroxylation accessible with cytochrome P450s. The utility of the method will be demonstrated through the preparation of industrially relevant products in continuous chemo-enzymatic cascades, in alignment with the principles set out in the MSCA Green Charter. UPOXARENE will promote biotechnology through the citizen-science initiative Peroxynauts, encouraging students from all backgrounds to pursue careers in the life sciences.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences catalysis biocatalysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2628 CN Delft
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.