Project description
Bacterial invasion in the human gut
The human gut microbiota defends against pathogens and supports vital metabolic and immune functions. However, our understanding of how gut microbiota influences bacterial invasion and evolution remains limited due to the complexity of these interactions. Supported by the Marie Skłodowska-Curie Actions programme, the MICROINVADER project addresses this knowledge gap by investigating how the commensal bacterium Escherichia coli invades and evolves within different human gut microbiota compositions. Utilising an established in vitro gut simulator, the project aims to elucidate the molecular mechanisms behind bacterial invasion and colonisation. By validating findings through in vitro and in vivo experiments, MICROINVADER seeks to uncover insights that could inform strategies to manipulate gut microbiota, ultimately enhancing human health and well-being.
Objective
The human gut microbiota plays a critical role in safeguarding human health by defending against pathogens and supporting essential metabolic and immune functions. Nevertheless, our understanding of how the gut microbiota influences bacterial invasion and evolution within the human body is incomplete due to the complexity of these interactions. Furthermore, the specific mechanisms through which commensal bacteria, such as Escherichia coli, successfully invade and evolve in distinct human gut microbiota compositions remain unclear.
The MICROINVADER project aims to address this knowledge gap, utilizing an established in vitro gut simulator to investigate the precise mechanisms underlying the successful invasion of distinct human gut microbiota ecosystems by the commensal bacterium E. coli. Furthermore, MICROINVADER aims to characterize at the molecular level the processes that shape the evolution of invading strains in response to specific human gut microbiota compositions. Subsequently, MICROINVADER will validate these findings through in vitro and in vivo experiments, focusing on quantifying the selection strength acting on the genetic mechanisms that are crucial for bacterial invasion and colonization in different human gut environments.
By unveiling these novel mechanisms driving bacterial invasion and colonization within diverse human gut microbiotas, MICROINVADER seeks to provide critical insights that may have far-reaching implications for enhancing human health. Ultimately, MICROINVADER aims to contribute to our understanding of how to manipulate the gut microbiota in ways that promote and sustain overall well-being.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences ecology ecosystems
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.