Project description
Understanding the role of stem cells during bone healing
Most tissues contain somatic stem cells which are crucial for regeneration. Skeletal stem progenitor cells (SSPCs) contribute to bone healing after fracture, contributing to cartilage and bone formation. Successful healing also requires the coordinated development of new blood vessels and nerves within the bone microenvironment. Disruption of these processes can lead to fibrosis and impaired repair. With the support of the Marie Skłodowska-Curie Actions programme, the CROSSBONE project will investigate the regulation of SSPCs in the niche and its role in healing. Researchers will employ a range of pathological models of healing to study how angiogenesis, nerve regeneration, and SSPC fate decisions are coordinated. Project findings will improve our understanding of fibrosis-related bone disorders and guide future therapies.
Objective
Bone fractures are common traumatic injuries and a significant global health challenge. Successful healing depends on skeletal stem progenitor cells (SSPCs) producing cartilage and bone via a complex process. New vessel and nerve formations in the bone microenvironment are also crucial to determine the healing outcome. When disrupted, bone healing is impaired and fibrosis emerges, impacting patients’ life. In current research on bone repair disorders, there is a lack of understanding of initial triggers influencing cell differentiation and healing outcomes. In Neurofibromatosis type 1 (NF1), the host laboratory identified an early SSPC shift from a chondrogenic fate to a fibrotic fate promoting fibrosis instead of bone formation. Analysing the factors causing this cell fate shift is essential to understand altered mechanisms in pathological conditions. CROSSBONE will address these needs by unveiling the SSPC niche initial regulatory mechanisms influencing bone healing and fibrosis. It will analyse healthy fracture healing, detailing angiogenesis, reinnervation and SSPC interactions. Then I will investigate NF1 pathological mechanisms, focusing on this crosstalk and how it can disrupt healing. The project will use complementary in vitro and in vivo experiments, single-cell transcriptomics, and advanced tools to dissect spatial-temporal crosstalk after fractures. These interdisciplinary methodologies will provide a comprehensive understanding of bone healing in healthy and pathological conditions. CROSSBONE will enhance my professional development, boosting independence and competitiveness for my future career. The findings will potentially impact the management of diseases where fibrosis influences bone healing, benefiting scientists, clinicians and patients in related fields. Integrating various disciplines and techniques, CROSSBONE aims to contribute pioneering insights into bone healing and fibrosis, supporting new therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.