Project description
Translation of messenger RNA and cancer progression
Regulation of gene expression takes place at multiple levels, including transcription, messenger RNA (mRNA) translation, and protein degradation. Translational regulation is especially powerful, as it allows cells to quickly change protein production without altering gene transcription. However, we still lack a comprehensive understanding of how translation is regulated across the whole transcriptome. With the support of the Marie Skłodowska-Curie Actions programme, the TRANSLATOME project aims to identify mRNAs whose translation is consistently co-regulated and investigate how these are orchestrated. To target dysregulated translation in cancer, researchers hope to identify the mechanisms causing translation changes and look into how these relate to breast cancer and glioblastoma.
Objective
The gene expression pathway includes transcription, mRNA translation, and protein degradation. Altered translation can rapidly modulate protein levels, without requiring changes in transcription, and can therefore efficiently control cellular responses. Despite evidence of key roles for transcript-selective modulation of translation, the extent and organization of translational control at a transcriptome-wide level is largely uncharted. Moreover, major cancer types appear to be under strong post-transcriptional regulation affecting metastasis and prognosis. TRANSLATOME aims to identify the organization and mechanisms underlying transcriptome-wide modulation of translation. First, I will explore and identify modules whose translation is consistently co-regulated across many cellular conditions, and therefore share common mechanisms, using network module identification. Dependencies between activities of translation modules, which are suggested from the preliminary data, will be studied in detail. This part will exploit polysome or ribosome profiling data from public repositories. Second, I will determine the mechanisms underlying translation modules and how their activities are orchestrated. This will be achieved by identifying RNA features driving the coordinated translation of mRNAs within modules, and how these – via encoded proteins – determine activities in key biological pathways. Finally, I will assess whether modules underlie translation patterns or subtypes of breast and glioblastoma tumours. This interdisciplinary approach requires molecular biology, bioinformatics, systems biology, algorithm development and applied statistics. TRANSLATOME will bring new insights into the transcriptome-wide organization of mRNA translation, which is pertinent to complex diseases. Particularly, I expect to elucidate how mRNA translation is altered in breast cancer and glioblastoma, paving the way for treatments aimed at reversing dysregulated translation programs in cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.