Project description
Proactive approach to understand and detect multiple sclerosis
The immune system protects against disease. However, when it malfunctions, it can cause autoimmune disorders such as multiple sclerosis (MS). MS leads to significant disability. Early detection is crucial, but current prognostic tools are ineffective. Supported by the Marie Skłodowska-Curie Actions programme, the AWARE-MS project will adopt a proactive approach to MS by modelling its progression to better understand the factors influencing relapse onset and severity. This initiative will integrate continuous data from wearable devices with interpretable physics-informed machine learning models. The project will enhance awareness of MS processes, improve treatment strategies and patients’ quality of life while reducing the overall healthcare burden related to MS.
Objective
The immune system protects the human body against disease and infection, but when it malfunctions, it can lead to autoimmune diseases like multiple sclerosis (MS). MS is a chronic inflammatory condition affecting the Central Nervous System, characterized by the demyelination of nerve fibers. It is currently one of the leading causes of non-traumatic disability worldwide, affecting 2.8 million of individuals. Most MS cases begin with relapsing-remitting episodes, marked by acute events, known as relapses, that occur frequently and present with severe sensorimotor symptoms. Early detection and prevention of relapses are crucial, as these events cause cumulative neurological damage that drives disease progression and leads to irreversible functional disability. A deeper understanding of MS relapses is vital for enabling effective, targeted care and improved disease management outcomes. Standard prognostic tools, like clinical scales, present weak predictive power, and more advanced solutions are still immature, lacking robust validation and interpretability. The AWARE-MS (Artificial intelligence and WeArables for the undeRstanding and Evaluation of Multiple Sclerosis) project aims at establishing a proactive approach to MS by modelling the evolution of MS to uncover the mechanisms underlying relapse onset and severity and ultimately address the early detection of exacerbations. The proposed framework integrates continuous multimodal data collected on MS patients via wearable devices with interpretable physics-informed machine learning (PIML) models. The project will leverage the biomedical expertise of Spaulding Rehabilitation Hospital (US) and the bioengineering and data science expertise of Scuola Superiore Sant’Anna (IT). AWARE-MS has the ambition of enhancing the awareness of MS processes to further impact treatment and decision strategies in the long-term, thus, improving patients’ quality of life and reducing the global healthcare burden associated with MS.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
56127 Pisa
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.