Obiettivo Regulation of gene expression is a complex phenomenon poorly understood. Our project aims to improve our knowledge about non-coding sequences, increasingly show to be relevant for modulating gene expression, using dystrophin gene and dystrophinopathies as model. Among the series of characterised patients, available in the collaborative units, several have unusual mutations and phenotype suggesting a role of non-coding regions. We will analyse these patients in order to identify and functionally study the regulatory sequences responsible. We will define the intronic breakpoints as well as other non-coding regions involved in dystrophin mutations. We will characterise these sequences by experimental studies to test their regulatory function with particular attention to those involved in pre-mRNA splicing. we will evaluate the feasibility of a targeted modulation of dystrophin gene expression using antisense oligonucleotides. Campo scientifico natural sciencesbiological sciencesgeneticsmutationnatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-8. - Research into genomes and diseases of genetic origin Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITA DEGLI STUDI DI FERRARA Contributo UE Nessun dato Indirizzo Via Savonarola 9 FERRARA Italia Mostra sulla mappa Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo South Kensington Campus LONDON Mostra sulla mappa Costo totale Nessun dato LEIDEN UNIVERSITY Paesi Bassi Contributo UE Nessun dato Indirizzo Wassenaarseweg 72 2300 RA LEIDEN Mostra sulla mappa Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI PADOVA Italia Contributo UE Nessun dato Indirizzo VIA U.BASSI 58/B 35131 PADOVA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF LEICESTER Regno Unito Contributo UE Nessun dato Indirizzo University Road LE1 7RH LEICESTER Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
