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The alternative splicing database- a novel tool to diagnose human disease

Ziel

The consortium proposes to create a database that contains all alternatively spliced axons from human, mouse, rat and drosophilae. Both manual duration and an automated computer pipeline from public databases will create the database. Alternative splicing has been increasingly recognized a reason for human disease and we will therefore develop a DNA chip that contains codas of all the splicing regulatory proteins and their is forms, as well as a chip that contains a number of disease relevant genes. We will concentrate on three models of disease (breast cancer, FTDP-17, male infertility) in which a connection between misplacing and a pathological state has been observed. Finally, an industrial partner to demonstrate that a human disease and possibly a predisposition to it can be detected will manufacture these chips.

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Finanzierungsplan

DEM - Demonstration contracts

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UNIVERSITY OF ERLANGEN-NUREMBERG
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Fahrstrasse 17
91054 Erlangen
Deutschland

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Letzte Aktualisierung: 13 Juni 2006

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/QLK3-CT-2002-02062/de

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