Oxygen-sensitive enzymes of the mevalonate-independent isoprenoid biosynthesis pathway as targets for new antimalarial and anti-TB drugs

Informations projet

02-SENSITIVE TARGETS

N° de convention de subvention: 516017

Projet clôturé

Date de début 1 Janvier 2005

Date de fin 31 Decembre 2006

Financé au titre de

• Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Coût total € 1 349 000,00

Contribution de l’UE € 1 000 000,00

Coordonné par

JUSTUS LIEBIG UNIVERSITY GIESSEN
Germany

Objectif

In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.

Champ scientifique

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › basic medicine › medicinal chemistry
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Mots‑clés

• high resolution screening
• iron-sulphur cluster
• isoprenoid biosynthesis
• malaria
• tuberculosis

Programme(s)

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Thème(s)

• LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies

Appel à propositions

FP6-2003-LIFESCIHEALTH-3
Voir d’autres projets de cet appel

Régime de financement

STIP - Specific Targeted Innovation Project

Coordinateur

JUSTUS LIEBIG UNIVERSITY GIESSEN

• Contribution de l’UE: Aucune donnée
• Adresse: Ludwigstrasse 24 ; GIESSEN ; Allemagne
• Coût total: Aucune donnée

Participants (2)

KIADIS B.V.

Pays-Bas

• Contribution de l’UE: Aucune donnée
• Adresse: Zernikepark 6-8 ; GRONINGEN
• Coût total: Aucune donnée

GHENT UNIVERSITY

Belgique

• Contribution de l’UE: Aucune donnée
• Adresse: Sint-Pietersnieuwstraat 25 ; GENT
• Coût total: Aucune donnée