Obiettivo The objective of this project is to co-finance a collaborative Workshop on "Systems biology of DNA damage induced stress responses" between researchers of the EU and the USA. The purpose of this Workshop is to develop better collaboration between researche rs in the EU and the US in a systems biology analysis of the principal pathways in the area of DNA-damage response. Heretofore, researchers focused on specific cellular compartments with regard to DNA-damage responses, such as cell cycle regulation, indu ction of apoptosis or DNA repair. However, work during the past few years has shown that there are strong interplays between specific steps in these major defence pathways and in order to fully understand cellular responses to DNA-damage, the cell must b e viewed as a large network of protein-protein and protein-DNA interactions that respond in a systematic way to DNA-damage. Researchers of the various DNA-damage response pathways have therefore recently embraced approaches in which global measurements of gene expression and the proteome can be combined with genome-wide screening of sensitivity mutants to develop an integrated view of how cells respond to and protect themselves against DNA damaging agents. The emerging picture from these global genomic studies is quite different from the previous concept of DNA repair, cell cycle control and induction of apoptosis as being independent processes. In fact these processes appear to form a fully integrated network. Integration of these genome-wide measure ments allows the development of specific models of response networks that could not have been detected or discerned previously. These models can be further refined and tested to improve mechanistic understanding. Specifically, the main goals of this Work shop are to enhance harmonization of protocols, to integrate databases and to increase communication between scientists in the EU and US in this field of research. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencescomputer and information sciencesinternetnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsmutation Parole chiave DNA damage collaboration EU-US genome wide transcriptional profiling stress response systems biology Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2002-3-2 - Stimulating international cooperation LSH-2003-3-6 - Realising ERA objectives Invito a presentare proposte FP6-2003-LIFESCIHEALTH-II Vedi altri progetti per questo bando Meccanismo di finanziamento SSA - Specific Support Action Coordinatore ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N LEIDEN UNIVERSITY MEDICAL CENTER) Contributo UE Nessun dato Indirizzo Wassenaarseweg 72 LEIDEN Paesi Bassi Mostra sulla mappa Costo totale Nessun dato