Objective Migraine is a common chronic pain syndrome, with recurrent attacks (1-3 days) of disabling headache,associated symptoms and, in 1/3 of patients, neurological aura symptoms. Over 12% of the general population (2/3 females) have migraine attacks regularly (median 18/year). WHO rates migraine in the highest class of most disabling chronic disorders. Migraine-related annual costs in the EU amount 10 billion euros. Acute attack treatments are satisfactorily in less than half of patients. Effective and well-tolerated prophylactic migraine agents are dearly needed.Genetic factors are involvedin the mechanisms for the attack, pain, and aura. EUROHEAD aims to identify and validate these genes, and unravel their functional involvement in migraine pathways by using clinical and (post)genomic techniques in patients and cellular and transgenic mouse models. To this extent, EUROHEAD combines the extensive clinical, genetic and neurobiologic expertise of leading scientists from 7 EU countries and access to a unique patient material. This includes large well-defined families, clinic-and population-based cohorts, families from genetic isolated populations (Finland; Costa Rica and 600,000 twin pairs from the EUfunded GENOMEUTWIN project.We assume that rare familial and common complex types of migraine share common genes and pathways.Focusing on families and isolates, integrated genome wide scans linkage disequilibrium mapping, bioinformatics and association studies will yield candidate genes. The function will be studied by using electrophysiological (e.g. cortical spreading depression), behavioural, and neuroimaging models Endophenotypes will be identified in clinical, attack-provocation, neurophyiological, and neuroimaging studies.The project will improve our understanding of the genetics and neurobiology of migraine, including molecular diagnostics and intervention targets. There are ample opportunities for SME' s and pharmaceutical companies to participate... Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsDNAnatural scienceschemical sciencesinorganic chemistryalkali metalsmedical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesgeneticsgenomes Keywords genetics headache man migraine neurobiology pain response transgenic mouse models treatment Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-2.1.3-8 - Genetics and neurobiology of pain Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator LEIDEN UNIVERSITY MEDICAL CENTER EU contribution No data Address Albinusdreef 2 9600 LEIDEN Netherlands See on map Links Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF HELSINKI Finland EU contribution No data Address Yliopistonkatu 4 UNIVERSITY OF HELSINKI, HELSINKI See on map Links Website Opens in new window Total cost No data INSTITUTE OF NEUROLOGY, UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Queen Square LONDON See on map Links Website Opens in new window Total cost No data UNIVERSITA' DEGLI STUDI DI PADOVA' Italy EU contribution No data Address Via VIII Febrraio 2 PADOVA See on map Links Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Italy EU contribution No data Address Via Olgettina 60 MILAN See on map Links Website Opens in new window Total cost No data UNIVERSITÄT DUISBURG ESSEN Germany EU contribution No data Address Universitaetstrasse 2 ESSEN See on map Links Website Opens in new window Total cost No data GLOSTRUP UNIVERSITY HOSPITAL Denmark EU contribution No data Address Ndr. Ringvej 57 GLOSTRUP COPENHAGEN See on map Links Website Opens in new window Total cost No data UNIVERSITY OF LIEGE Belgium EU contribution No data Address Place du XX Aout, LIEGE See on map Links Website Opens in new window Total cost No data IRCCS NEUROLOGICAL INSTITUTE "CASIMIRO MONDINO" Italy EU contribution No data Address Via Palestro 6 PAVIA See on map Links Website Opens in new window Total cost No data