Obiettivo Model organisms are essential to study the genetic basis of human diseases. Transgenic mammalian models, especially genetic knock-out mice catalysed the progress. To continue the advancement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. In order to enhance our genetic understanding of human diseases, this proposal is aimed to develop new tools for the generation of transgenic laboratory animal models both in mouse and rat for comparative analyses of functional genomics in different species. In the mouse stable embryonic stem cell lines enable gene-targeting technology. However, the lack of such cell lines in most mammalians has so far prevented targeted genetic modifications.This proposal is aimed to use new tools such as nuclear replacement and gene targeting in somatic cells as a technological platform for producing new transgenic models. The primary aim is to further explore and validate the nuclear replacement system for safety and reliability as a technological platform. Our goal is also to generate the first gene targeted rat models. Relevant issues, such as the role of mitochondrial inheritance, somatic cell gene targeting and standardisation of newly generated genotypes by cryo-preservation will be addressed as well. Campo scientifico medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cells Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Invito a presentare proposte FP6-2004-LIFESCIHEALTH-5 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore AGRICULTURAL BIOTECHNOLOGY CENTER Contributo UE Nessun dato Indirizzo Szent Gyorgyi Albert utca 4. GODOLLO Ungheria Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BIOTALENTUM LTD. Ungheria Contributo UE Nessun dato Indirizzo Aulich Lajos 26 GÖDÖLLO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) Germania Contributo UE Nessun dato Indirizzo Ingolstaedter Landstrasse 1 NEUHERBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF COPENHAGEN Danimarca Contributo UE Nessun dato Indirizzo Noerregade 10 COPENHAGEN K Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF NOTTINGHAM Regno Unito Contributo UE Nessun dato Indirizzo University Park NOTTINGHAM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF VETERINARY MEDICINE, VIENNA Austria Contributo UE Nessun dato Indirizzo Veterinaerplatz 1 VIENNA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
