Objective
The overall goal is to develop a complex training program for PhD students on mammalian developmental biology, embryology, stem cell research combined with transgenic technology, genetic reprogramming, laboratory animal science and appropriate micromanipulation, microscopic imaging and molecular biological methods, using real-time PCR, micro-arrays andproteomics. Such training would reduce the fragmentation in the ERA in these areas and would enable the graduates to tackle the complexity of transgenic model and genetic reprogramming research. The research rationale of the project is that model organisms are essential to study the genetic basis of human diseases. Transgenic models, especially genetic knock-out mice catalysed the progress. To continue the advan cement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. This proposal is aimed to develop new tools for the generation of transgenic laboratory animal models both in mo use and rat for comparative analyses of functional genomics. In the mouse stable embryonic stem cell lines enable gene targeting. However, the lack of such cell lines in most mammalians has so far prevented targeted genetic modifications. This proposal is aimed to use new tools such as nuclear replacement and gene targeting in somatic cells as a technological platform for producing new transgenic models. The aim is to further explore and validate the nuclear replacement system for safety and reliability as a technological platform. Our goal is also to generate the first gene targeted rat models. Relevant issues, such as the role of mitochondrial inheritance, somatic cell gene targeting and standardisation of new genotypes by cryo-preservation will be addresse d. Generation of embryonic stem cell lines from cloned embryos and use of embryonic stem cells for partial reprogramming of somatic cells will be studied, as well.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences animal and dairy science
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences developmental biology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GODOLLO
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.