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Genotype-To-Phenotype Databases: A Holistic Solution

Genotype-To-Phenotype Databases: A Holistic Solution

Objective

The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seamless G2P biomedical knowledge environment. The project will then utilise these elements to construct an operational first-version of that knowledge environment, by the projects end. This will consist of a European-centred but globally-networked hierarchy of bioinformatics GRID-linked databases, tools and standards, all tied into the Ensembl genome browser. The project has the following specific objectives: 1) To analyse the G2P field and thus determine emerging needs and practices; 2) To develop key standards for the G2P database field; 3) To create generic database components, services, and integration infrastructures for the G2P database domain; 4) To create search modalities and data presentation solutions for G2P knowledge; 5) To facilitate the process of populating G2P databases; 6) To build a major G2P internet portal; 7) To deploy GEN2PHEN solutions to the community; 8) To address system durability and long-term financing; 9) To undertake a whole-system utility and validation pilot study GEN2PHEN Consortium members have been selected from a talented pool of European research groups and companies that are interested in the G2P database challenge. Additionally, a few non-EU participants have been included to bring extra capabilities to the initiative. The final constellation is characterised by broad and proven competence, a network of established working relationships, and high-level roles/connections within other significant projects in this domain.

Coordinator

UNIVERSITY OF LEICESTER

Address

University Road
Le1 7rh Leicester

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 685 819,72

Administrative Contact

Marie Adams (Ms.)

Participants (22)

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EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 1 889 510

FUNDACIO INSTITUT MAR D INVESTIGACIONS MEDIQUES IMIM

Spain

EU Contribution

€ 722 682,09

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 1 158 437

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 855 897,39

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 169 080

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Greece

EU Contribution

€ 215 011

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 190 523

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 258 088,59

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 824 799

UNIVERSIDADE DE AVEIRO

Portugal

EU Contribution

€ 346 766

UNIVERSITY OF THE WESTERN CAPE

South Africa

EU Contribution

€ 60 435,28

COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

India

EU Contribution

€ 229 521

SIB INSTITUT SUISSE DE BIOINFORMATIQUE

Switzerland

EU Contribution

€ 257 138

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 701 614

BIOBASE GMBH

Germany

EU Contribution

€ 153 285

ISLENSK ERFDAGREINING EHF

Iceland

EU Contribution

€ 37 230,61

PHENOSYSTEMS SA

Belgium

EU Contribution

€ 141 279

BIOCOMPUTING PLATFORMS LTD OY

Finland

EU Contribution

€ 184 901

PANEPISTIMIO PATRON

Greece

EU Contribution

€ 360 859,41

SYNAPSE RESEARCH MANAGEMENT PARTNERS SL

Spain

EU Contribution

€ 346 489,91

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 50 000

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 50 000

Project information

Grant agreement ID: 200754

Status

Closed project

  • Start date

    1 January 2008

  • End date

    30 June 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 14 816 974,92

  • EU contribution

    € 11 889 367

Coordinated by:

UNIVERSITY OF LEICESTER

United Kingdom