Objective
Many bacteria, including human and animal pathogens can acquire a high-resistance state as a consequence of exposure to stress. Since in their natural environments, bacteria seldom encounter conditions that allow exponential growth, understanding the mechanism/s behind stress-induced cross-resistance is of uttermost importance for the control of bacterial populations. In particular, the epidemiology and virulence of many human, animal, and plant pathogens appears to be related to stress-induced cross-resistance and phenomena such as biofilm formation appear to be the direct consequence of exposure to environmental stress. Therefore, understanding these bacterial survival strategies has important medical and economical implications. The research proposed here aims at the characterization of the molecular details behind the strategies used by two different Gram negatives, Escherichia coli and Vibrio anguillarum, for the development of stress-induced cross-resistance.
E. coli is the organism for which the most detailed picture of cellular physiology exists and has been commonly used as a model for the study of the bacterial protein synthesis and the response to stress. My previous research with this organism has uncovered an important link between the ribosome and the process of stress-induced cross-resistance. The molecular details of this phenomenon will be explored in Specific Aim I.
V. anguillarum is the fish pathogen which causes vibriosis, a devastating disease affecting aquaculture. Therefore, there exists high economic interest in developing methods for the control of this bacterium. Increased virulence in V. anguillarum appears to be related to iron deficiency, a common type of environmental stress. The goal of Specific Aim II is to study the cellular response to iron deficiency as well as the molecular details of iron uptake in V. anguillarum, so that strategies for its containment can be designed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences public health epidemiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
15001 La Coruna
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.