Project description DEENESFRITPL Microplastic pollution under the microscope The rise in plastic pollution of the ocean is visible, but some plastics are so small they cannot be seen by the naked eye. At the sub-five-millimetre down to nanometre scale, these tiny plastics are also entering the environment and posing a huge concern for biota and human health. The EU-funded Imptox project will develop an analytical platform to investigate the effect and toxicity of micro- and nanoplastic particles (MNPs) combined with environmental contaminants on the risk of allergic disease in preclinical and clinical studies. The platform will be designed to find suitable analytical approaches for determining the extent of the problem. Findings will lead to novel tools for MNP detection and increased awareness of disease risk. Show the project objective Hide the project objective Objective There is an urgent need to understand the risks on human health of micro- and nano-plastic particles (MNPs) that contaminate food and environment. We aim to create a cross-disciplinary platform to design suitable analytical approaches for determining the extent of the problem in the environment and to our health by evaluating the influence of ingested and inhaled exposure of MNPs contaminated with metals, allergens, pathogenic bacteria and toxins on allergic responses. Our strategy includes developing a novel combination of tools to identify, extract, characterize, and quantify MNPs from selected foods, environmental media, and tissues of exposed animals to assess MNP prevalence based on size, shape and type. We will produce and label MNPs for use in a variety of pre-clinical studies to investigate toxicity and responses to MNPs, contaminants and allergens. We plan to use novel stable isotope 13C labelling and detection to determine MNP fate and accumulation in the gastrointestinal and respiratory tracts and secondary organs after immediate and chronic exposure and the effect on allergic immune responses at the cellular and molecular levels. Additionally, we designed a clinical study to evaluate the influence of MNP exposure in humans. The outcome of this state-of-the-art project includes - novel tools for MNP detection - improved understanding of the effects of NMPs combined with critical contaminants in the air, water and food on human health and discovery of predictive biomarkers - increased awareness of disease risk in response to MNPs and contaminants - improved communication strategies between science and relevant stakeholders and contribution to blue growth and the health-relevant aims of the European Strategy for Plastics in a Circular Economy - policy-relevant scientific data in support of improved human health hazard and risk assessment and for response and mitigation policies at the national and EU level for policymakers.ImpTox is part of the European MNP cluster on human health. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicineimmunologysocial scienceseconomics and businesseconomicssustainable economy Keywords microplastics absorption contaminant environment diet allergy asthma digestion toxicity pathogenic microorganisms isotope ratio mass spectrometry Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) SC1-BHC-36-2020 - Micro- and nano-plastics in our environment: Understanding exposures and impacts on human health Call for proposal H2020-SC1-BHC-2018-2020 See other projects for this call Sub call H2020-SC1-2020-Single-Stage-RTD Funding Scheme RIA - Research and Innovation action Coordinator HEMIJSKI FAKULTET, UNIVERZITET U BEOGRADU Net EU contribution € 881 750,00 Address STUDENTSKI TRG 12-16 11001 Beograd Serbia See on map Region Србија - север Београдски регион Београдска област Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 881 750,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all MOVERIM CONSULTING SRL Belgium Net EU contribution € 181 897,00 Address SQUARE AMBIORIX 32 1000 Bruxelles / Brussel See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 181 897,50 PROMOSCIENCE SRL Italy Net EU contribution € 253 437,50 Address LOCALITA PADRICIANO 99 34012 Trieste See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 253 437,50 MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 683 950,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 683 950,00 KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 399 353,75 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 399 353,75 UNIVERSITEIT GENT Belgium Net EU contribution € 1 219 750,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 219 750,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 599 335,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 599 335,00 UNIVERSITAT WIEN Austria Net EU contribution € 389 725,00 Address UNIVERSITATSRING 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 389 725,00 SCIENSANO Belgium Net EU contribution € 347 500,00 Address JULIETTE WYTSMANSTRAAT 14 1050 Elsene See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 347 500,00 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 362 800,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 362 800,00 Srebrnjak Children's Hospital Croatia Net EU contribution € 401 555,00 Address Srebrnjak 100 10000 Zagreb See on map Region Hrvatska Grad Zagreb Grad Zagreb Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 401 555,00 HAUTE ECOLE SPECIALISEE DE SUISSE OCCIDENTALE Switzerland Net EU contribution € 383 770,00 Address Route de Moutier 14 2800 Delemont See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Jura Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 383 770,00
