A micronutrient information portal
Micronutrients such as vitamins, zinc, selenium and antioxidants are required in small amounts for normal physiological function and influence various processes including oxidative stress and inflammation. Optimum micronutrient supply is important for the maintenance of metabolic homeostasis and overall good health. Research data and information on the health effects of these nutrients is fragmented and sparsely disseminated. The community-driven micronutrient genomics project (MGP) was established to facilitate the systematic storage, analyses, and dissemination of information on micronutrient–genome interactions. The EU-funded MICROGENNET (Extension, enhancement and strengthening of established collaborations for the purpose of a community-driven knowledge base for micronutrient genomics) project brought together leading experts from around the world to identify metabolic and functional target pathways for a range of micronutrients. Research focused on selenium, zinc, vitamins and vitamin-related compounds and anti-oxidants. Scientists studied the interaction of folate, vitamin B12 and riboflavin within the folate-methionine metabolic cycle and determined their optimal requirements. They extended existing knowledge on the relationship between single nucleotide polymorphisms and selenium status to colorectal cancer risk. This information underscored the dynamics of selenium supplementation. Furthermore, scientists investigated various zinc-dependent mechanisms in the respiratory system and elucidated the role of zinc in the regulation of cell death mechanisms. With respect to carotenoids, they tested the importance of genetic variation and epigenetic changes on nutrient bioavailability and immune function. Significant effort went towards the genetic modifiers of serum vitamin C and how the latter interacts with proteins in the plasma. The role of vitamin D on gene expression and how deficiency can lead to DNA damage was also investigated. Collectively, the results on micronutrient-relevant pathways were shared with the whole research community via the popular online pathway platform, WikiPathways. Overall, the MICROGENNET-generated data allows the evaluation of micronutrient effects on various biological processes. Translation of this information into recommendations for supplement intake is expected to improve health and prevent chronic diseases.
Keywords
Micronutrient, vitamins, micronutrient genomics project, MICROGENNET, WikiPathways
