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Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases

Descripción del proyecto

Aprovechamiento de la biodiversidad marina para descubrir bioprotectores novedosos

La bioprospección puede ofrecer microbiomas y productos microbianos naturales que promuevan la resistencia a enfermedades centrándose en interacciones únicas hospedador-microbio en esponjas marinas, microalgas y peces. El proyecto MARBLES, financiado con fondos europeos, utilizará una estrategia de bioprospección basada en la ecología para desvelar los agentes bioactivos en microbiomas supresores de enfermedades y estudiar sustancias químicas derivadas de los microbios y los hospedadores que desencadenan la producción de compuestos bioactivos. Los resultados incluirán consorcios microbianos y productos naturales bioactivos, sus derivados y elicitores, que pueden utilizarse para combatir enfermedades infecciosas en los sectores agroquímico y de la acuicultura, y en sanidad. Además, la producción sostenible de bioprotectores mejorará la producción piscícola, reducirá la presión sobre la pesca de poblaciones silvestres y facilitará la transición a soluciones circulares de origen biológico.

Objetivo

MARBLES will use a novel and systematic approach to access and exploit marine microbial biodiversity for sustainable bioprospecting to discover microbial consortia and bioactive molecules for application in aqua- and agriculture and in the clinic. MARBLES' ecology-based bioprospecting strategy will focuses on unique host-microbe interactions in marine environments, including marine sponges, microalgae and fish, which rely on their microbiomes and microbial natural products for disease resistance. Partners’ existing microbial collections and new ones generated during MARBLES will be harnessed for the discovery of novel natural products and synthetic microbial communities. For this, MARBLES will use a systems-wide genomics approach to uncover the bioactive agents in disease-suppressive microbiomes. Also, MARBLES will explore host- and microbe-derived chemicals that elicit production of bioactive compounds, as elicitors to revitalise drug screening. The deliverables will be microbes and consortia and bioactive natural products, their derivatives and elicitors, which can be harnessed to fight infectious diseases in the agrochemical and aquaculture industries and in healthcare.
Besides highly innovative, the approaches will be cost-effective and will offer advantages from both environmental and health perspectives in comparison to existing alternatives. The sustainable production of bioprotectants will increase the effectiveness of fish production - reducing the pressure on harvesting wild fish - and aid the transition of the crop agriculture sector towards bio-based and circular solutions. MARBLES will work closely together with a panel of SMEs and large companies from the EU aquaculture, crop protection biotechnology and health sectors. MARBLES fully complies with the Nagoya and Cartagena Protocols, and aims to make major contributions to the UN sustainable development goals, SDG 2, 3, 12, 13 and 14, as well as to current UN processes (BBNJ, DSI, SynBio)

Convocatoria de propuestas

H2020-FNR-2020

Consulte otros proyectos de esta convocatoria

Convocatoria de subcontratación

H2020-FNR-2020-2

Régimen de financiación

RIA - Research and Innovation action

Coordinador

UNIVERSITEIT LEIDEN
Aportación neta de la UEn
€ 1 098 620,00
Dirección
RAPENBURG 70
2311 EZ Leiden
Países Bajos

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Región
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 1 098 620,00

Participantes (13)