Integrating biology and behaviour for precision stratification of mental disorders

Project Information

MENTALPRECISION

Grant agreement ID: 101001118

DOI

10.3030/101001118

EC signature date 8 April 2021

Start date 1 June 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Data management plan

Publications

Peer reviewed articles (31)

Functional Network Connectivity Deviation Is Associated With Transdiagnostic Symptomatology: Brain Connectivity Links to Transdiagnostic Symptoms

Author(s): Josina D. Kist, Charlotte Fraza, Hannah S. Savage, Peter C.R. Mulders, Janna N. Vrijsen, Rose M. Collard, Indira Tendolkar, Philip van Eijndhoven, Andre F. Marquand
Published in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Publisher: Elsevier BV
DOI: 10.1016/j.bpsc.2025.09.014

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

Author(s): Hannah S. Savage, Peter C. R. Mulders, Philip F. P. van Eijndhoven, Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen, Christian F. Beckmann, Andre F. Marquand
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06573-z

Objective QC for diffusion MRI data: Artefact detection using normative modelling

Author(s): Ramona Cirstian, Natalie J. Forde, Jesper L. R. Andersson, Stamatios N. Sotiropoulos, Christian F. Beckmann, Andre F. Marquand
Published in: Imaging Neuroscience, 2024, ISSN 2837-6056
Publisher: MIT Press
DOI: 10.1162/imag_a_00144

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Author(s): Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcís Cardoner, Jeggan Tiego, Murat Yücel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Published in: Nature Neuroscience, Issue 26, 2023, Page(s) 1613–1629, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01404-6

Using normative models pre-trained on cross-sectional data to evaluate intra-individual longitudinal changes in neuroimaging data

Author(s): Barbora Rehak Buckova, Charlotte Fraza, Rastislav Rehák, Marián Kolenič, Christian F Beckmann, Filip Španiel, Andre F Marquand, Jaroslav Hlinka
Published in: eLife, Issue 13, 2025, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.95823.4

Closing the Life-Cycle of Normative Modeling Using Federated Hierarchical Bayesian Regression

Author(s): Kia, Seyed Mostafa, Hester Huijsdens, Saige Rutherford, Augustijn de Boer, Richard Dinga, Thomas Wolfers, Pierre Berthet, et al
Published in: PLOS ONE, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0278776

Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features

Author(s): Milin Kim, Nitin Sharma, Esten H. Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Aikaterina Manoli, Sofie L. Valk, Dag Alnæs, Christian F. Beckman, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Published in: Biological Psychiatry Global Open Science, 2025, ISSN 2667-1743
Publisher: Elsevier
DOI: 10.1101/2024.12.10.24318590

Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth

Author(s): Rikka Kjelkenes, Thomas Wolfers, Dag Alnæs, Dennis van der Meer, Mads Lund Pedersen, Andreas Dahl, Irene Voldsbekk, Torgeir Moberget, Christian K Tamnes, Ole A Andreassen, Andre F Marquand, Lars T Westlye
Published in: Biology Psychiatry Global Open Science, 2023, ISSN 2667-1743
Publisher: Elsevier
DOI: 10.1016/j.bpsgos.2022.01.007

Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model

Author(s): Charlotte Fraza, Mariam Zabihi, Christian F. Beckmann, Andre F. Marquand
Published in: Human Brain Mapping, Issue 46, 2025, ISSN 1065-9471
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hbm.70281

Understanding individual neurodegenerative progression in Parkinson’s disease through normative modelling

Author(s): Charlotte Fraza, Barbora Rehák Bučková, Martin E. Johansson, Rick C. Helmich, Andre F. Marquand, Christian F. Beckmann
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-20484-x

Framework for Brain-Derived Dimensions of Psychopathology

Author(s): Tristram A. Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Argyris Stringaris, Lea Waller, Zuo Zhang, Jeanne Wintere
Published in: JAMA Psychiatry, Issue 82, 2025, Page(s) 778, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2025.1246

Striatal Connectopic Maps Link to Functional Domains across Psychiatric Disorders’

Author(s): Mulders, Peter C. R., Philip F. P. van Eijndhoven, Jasper van Oort, Marianne Oldehinkel, Fleur A. Duyser, Josina D. Kist, Rose M. Collard, et al
Published in: Translational Psychiatry, 2022, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-022-02273-6

Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models

Author(s): Johanna M.M. Bayer, Richard Dinga, Seyed Mostafa Kia, Akhil R. Kottaram, Thomas Wolfers, Jinglei Lv, Andrew Zalesky, Lianne Schmaal, Andre Marquand
Published in: Neuroimage, 2022, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2022.119699

Unraveling the link between CNVs, cognition and individual neuroimaging deviation scores from a population-based reference cohort

Author(s): Charlotte Fraza, Ida E. Sønderby, Rune Boen, Yingjie Shi, Christian F. Beckmann, Andre F. Marquand
Published in: Nature Mental Health, Issue 2, 2024, Page(s) 1451-1463, ISSN 2731-6076
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00322-1

The normative modeling framework for computational psychiatry

Author(s): Saige Rutherford, Seyed Mostafa Kia, Thomas Wolfers, Charlotte Fraza, Mariam Zabihi, Richard Dinga, Pierre Berthet, Amanda Worker, Serena Verdi, Henricus G. Ruhe, Christian F. Beckmann & Andre F. Marquand
Published in: Nature Protocols, Issue 17, 2022, Page(s) 1711–1734, ISSN 1750-2799
Publisher: Springer Nature
DOI: 10.1038/s41596-022-00696-5

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive

Author(s): Natalie Remiszewski, James Edward Bryant, Saige E. Rutherford, Andre F. Marquand, Eric Nelson, Ibrahim Askar, Adrienne Carol Lahti, Nina Vanessa Kraguljac
Published in: JAMA Psychiatry, 2022, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2022.3010

Charting Brain Growth and Aging at High Spatial Precision

Author(s): Rutherford, Saige, Charlotte Fraza, Richard Dinga, Seyed Mostafa Kia, Thomas Wolfers, Mariam Zabihi, Pierre Berthet, et al.
Published in: eLife, Issue e72904, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.72904

The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research

Author(s): Nilakshi Vaidya, Andre F. Marquand, Frauke Nees, Sebastian Siehl, Gunter Schumann
Published in: Molecular Psychiatry, Issue 29, 2024, Page(s) 3245-3267, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02556-y

Non-Gaussian normative modelling with hierarchical Bayesian regression

Author(s): Augustijn A. A. de Boer, Johanna M. M. Bayer, Seyed Mostafa Kia, Saige Rutherford, Mariam Zabihi, Charlotte Fraza, Pieter Barkema, Lars T. Westlye, Ole A. Andreassen, Max Hinne, Christian F. Beckmann, Andre Marquand
Published in: Imaging Neuroscience, Issue 2, 2024, Page(s) 1-36, ISSN 2837-6056
Publisher: MIT Press
DOI: 10.1162/imag_a_00132

From smartphone data to clinically relevant predictions: A systematic review of digital phenotyping methods in depression

Author(s): Imogen E. Leaning, Nessa Ikani, Hannah S. Savage, Alex Leow, Christian Beckmann, Henricus G. Ruhé, Andre F. Marquand
Published in: Neuroscience & Biobehavioral Reviews, Issue 158, 2024, Page(s) 105541, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105541

A stable and replicable neural signature of lifespan adversity in the adult brain

Author(s): Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Published in: Nature Neuroscience, Issue 26, 2023, Page(s) 1603–1612, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Evidence for embracing normative modeling

Author(s): Saige Rutherford, Pieter Barkema, Ivy F Tso, Chandra Sripada, Christian F Beckmann, Henricus G Ruhe, Andre F Marquand
Published in: eLife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85082

Smartphone keyboard dynamics predict affect in suicidal ideation

Author(s): Loran Knol, Anisha Nagpal, Imogen E. Leaning, Elena Idda, Faraz Hussain, Emma Ning, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Andre F. Marquand & Alex Leow
Published in: NPJ Digital Medicine, 2023, ISSN 2398-6352
Publisher: Springer Nature
DOI: 10.1038/s41746-024-01048-1

Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis

Author(s): Ramona Cirstian, Natalie J. Forde, Hui Zhang, Gerhard S. Hellemann, Christian F. Beckmann, Nina V. Kraguljac, Andre F. Marquand
Published in: Biological Psychiatry, 2025, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2025.07.021

Mapping cerebellar anatomical heterogeneity in mental and neurological illnesses

Author(s): Milin Kim, Esten Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Christian F. Beckmann, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Published in: Nature Mental Health, Issue 2, 2024, Page(s) 1196-1207, ISSN 2731-6076
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00297-z

Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study

Author(s): Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Lianne M Reus, Pieter Jelle Visser, Martien J H Kas, Christian F Beckmann, Henricus G Ruhé, Andre F Marquand
Published in: Journal of Medical Internet Research, Issue 27, 2025, Page(s) e64007, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/64007

Neural correlates of human fear conditioning and sources of variability in 2199 individuals

Author(s): Joaquim Radua, Hannah S. Savage, Enric Vilajosana, Alec Jamieson, Birgit Abler, Fredrik Åhs, Tom Beckers, Narcís Cardoner, Josh M. Cisler, Juliana B. Diniz, Dominik R. Bach, Sigrid Elsenbruch, Steven G. Greening, Daphne J. Holt, Antonia N. Kaczkurkin, Andreas Keil, Merel Kindt, Kathrin Koch, Kevin S. LaBar, Charlene L. Lam, Christine L. Larson, Tina B. Lonsdorf, Christian J. Merz, Katie A. McLau
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-63078-x

Warped Bayesian Linear Regression for Normative Modelling of Big Data

Author(s): Fraza, Charlotte J., Richard Dinga, Christian F. Beckmann, and Andre F. Marquand
Published in: NeuroImage, Issue 245, 2021, Page(s) 118715, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2021.118715

The promise of quantifying individual risk for brain disorders through normative modeling, a narrative review

Author(s): Charlotte Fraza, Saige Rutherford, Barbora Rehák Bučková, Christian F. Beckmann, Andre F. Marquand
Published in: Neuroscience & Biobehavioral Reviews, Issue 176, 2025, Page(s) 106284, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2025.106284

Exploring brain structural effects of dopaminergic antagonism and partial agonism in antipsychotic‐naïve patients with first‐episode psychosis using normative modeling

Author(s): Anna Feveile, Karen S. Ambrosen, Ketevan Shalikashvili, Jayachandra M. Raghava, Mette Ø. Nielsen, Kirsten B. Bojesen, Barbora R. Bučková, Andre F. Marquand, Birte Y. Glenthøj, Warda T. Syeda, Bjørn H. Ebdrup
Published in: Psychiatry and Clinical Neurosciences, 2026, ISSN 1323-1316
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pcn.70017

Predictive Clinical Neuroscience Portal (PCNportal): instant online access to research-grade normative models for clinical neuroscientists

Author(s): Pieter Barkema, Saige Rutherford, Hurng-Chun Lee, Seyed Mostafa Kia, Hannah Savage, Christian Beckmann, Andre Marquand
Published in: Wellcome Open Research, 2023, ISSN 2398-502X
Publisher: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.19591.2

Other (4)

Unobtrusive inference of diurnal rhythms from smartphone data

Author(s): Loran Knol, Mindy K. Ross, Anisha Nagpal, Andrew P. Burns, Zachery D. Morrissey, Faraz Hussain, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Alex Leow, Andre F. Marquand
Published in: 2026
Publisher: openRxiv
DOI: 10.1101/2025.04.14.25325807

Do you match what I match? A systematic review of 20 years of the emotional face matching task reveals vast inconsistencies in design and implementation.

Author(s): Hannah Savage, Linda Schlüter, Imogen Leaning, Christian Beckmann, null Andre
Published in: 2024
Publisher: Center for Open Science
DOI: 10.31234/osf.io/m5wnq

Did you miss me? Making the most of digital phenotyping data by imputing missingness with point process models

Author(s): Imogen E. Leaning, Andrea Costanzo, Raj Jagesar, Loran Knol, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Lianne M Reus, Pieter Jelle Visser, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Published in: 2026
Publisher: openRxiv
DOI: 10.1101/2025.05.13.25327521

More than one piece of the puzzle: considering non-clinical factors for personalisation in digital phenotyping

Author(s): Imogen E. Leaning, Linda Schlüter, Imke de Wijs, Mila Brandsen, Mila Roozen, Raj Jagesar, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Published in: 2026
Publisher: openRxiv
DOI: 10.1101/2025.11.18.25340238