Integrating biology and behaviour for precision stratification of mental disorders

Informazioni relative al progetto

MENTALPRECISION

ID dell’accordo di sovvenzione: 101001118

DOI

10.3030/101001118

Data della firma CE 8 Aprile 2021

Data di avvio 1 Giugno 2021

Data di completamento 30 Novembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Data management plan

Pubblicazioni

Peer reviewed articles (31)

Functional Network Connectivity Deviation Is Associated With Transdiagnostic Symptomatology: Brain Connectivity Links to Transdiagnostic Symptoms

Autori: Josina D. Kist, Charlotte Fraza, Hannah S. Savage, Peter C.R. Mulders, Janna N. Vrijsen, Rose M. Collard, Indira Tendolkar, Philip van Eijndhoven, Andre F. Marquand
Pubblicato in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Editore: Elsevier BV
DOI: 10.1016/j.bpsc.2025.09.014

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

Autori: Hannah S. Savage, Peter C. R. Mulders, Philip F. P. van Eijndhoven, Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen, Christian F. Beckmann, Andre F. Marquand
Pubblicato in: Communications Biology, Numero 7, 2024, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06573-z

Objective QC for diffusion MRI data: Artefact detection using normative modelling

Autori: Ramona Cirstian, Natalie J. Forde, Jesper L. R. Andersson, Stamatios N. Sotiropoulos, Christian F. Beckmann, Andre F. Marquand
Pubblicato in: Imaging Neuroscience, 2024, ISSN 2837-6056
Editore: MIT Press
DOI: 10.1162/imag_a_00144

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Autori: Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcís Cardoner, Jeggan Tiego, Murat Yücel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Pubblicato in: Nature Neuroscience, Numero 26, 2023, Pagina/e 1613–1629, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-023-01404-6

Using normative models pre-trained on cross-sectional data to evaluate intra-individual longitudinal changes in neuroimaging data

Autori: Barbora Rehak Buckova, Charlotte Fraza, Rastislav Rehák, Marián Kolenič, Christian F Beckmann, Filip Španiel, Andre F Marquand, Jaroslav Hlinka
Pubblicato in: eLife, Numero 13, 2025, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.95823.4

Closing the Life-Cycle of Normative Modeling Using Federated Hierarchical Bayesian Regression

Autori: Kia, Seyed Mostafa, Hester Huijsdens, Saige Rutherford, Augustijn de Boer, Richard Dinga, Thomas Wolfers, Pierre Berthet, et al
Pubblicato in: PLOS ONE, 2022, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0278776

Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features

Autori: Milin Kim, Nitin Sharma, Esten H. Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Aikaterina Manoli, Sofie L. Valk, Dag Alnæs, Christian F. Beckman, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Pubblicato in: Biological Psychiatry Global Open Science, 2025, ISSN 2667-1743
Editore: Elsevier
DOI: 10.1101/2024.12.10.24318590

Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth

Autori: Rikka Kjelkenes, Thomas Wolfers, Dag Alnæs, Dennis van der Meer, Mads Lund Pedersen, Andreas Dahl, Irene Voldsbekk, Torgeir Moberget, Christian K Tamnes, Ole A Andreassen, Andre F Marquand, Lars T Westlye
Pubblicato in: Biology Psychiatry Global Open Science, 2023, ISSN 2667-1743
Editore: Elsevier
DOI: 10.1016/j.bpsgos.2022.01.007

Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model

Autori: Charlotte Fraza, Mariam Zabihi, Christian F. Beckmann, Andre F. Marquand
Pubblicato in: Human Brain Mapping, Numero 46, 2025, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.70281

Understanding individual neurodegenerative progression in Parkinson’s disease through normative modelling

Autori: Charlotte Fraza, Barbora Rehák Bučková, Martin E. Johansson, Rick C. Helmich, Andre F. Marquand, Christian F. Beckmann
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-20484-x

Framework for Brain-Derived Dimensions of Psychopathology

Autori: Tristram A. Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Argyris Stringaris, Lea Waller, Zuo Zhang, Jeanne Wintere
Pubblicato in: JAMA Psychiatry, Numero 82, 2025, Pagina/e 778, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2025.1246

Striatal Connectopic Maps Link to Functional Domains across Psychiatric Disorders’

Autori: Mulders, Peter C. R., Philip F. P. van Eijndhoven, Jasper van Oort, Marianne Oldehinkel, Fleur A. Duyser, Josina D. Kist, Rose M. Collard, et al
Pubblicato in: Translational Psychiatry, 2022, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-022-02273-6

Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models

Autori: Johanna M.M. Bayer, Richard Dinga, Seyed Mostafa Kia, Akhil R. Kottaram, Thomas Wolfers, Jinglei Lv, Andrew Zalesky, Lianne Schmaal, Andre Marquand
Pubblicato in: Neuroimage, 2022, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2022.119699

Unraveling the link between CNVs, cognition and individual neuroimaging deviation scores from a population-based reference cohort

Autori: Charlotte Fraza, Ida E. Sønderby, Rune Boen, Yingjie Shi, Christian F. Beckmann, Andre F. Marquand
Pubblicato in: Nature Mental Health, Numero 2, 2024, Pagina/e 1451-1463, ISSN 2731-6076
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00322-1

The normative modeling framework for computational psychiatry

Autori: Saige Rutherford, Seyed Mostafa Kia, Thomas Wolfers, Charlotte Fraza, Mariam Zabihi, Richard Dinga, Pierre Berthet, Amanda Worker, Serena Verdi, Henricus G. Ruhe, Christian F. Beckmann & Andre F. Marquand
Pubblicato in: Nature Protocols, Numero 17, 2022, Pagina/e 1711–1734, ISSN 1750-2799
Editore: Springer Nature
DOI: 10.1038/s41596-022-00696-5

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive

Autori: Natalie Remiszewski, James Edward Bryant, Saige E. Rutherford, Andre F. Marquand, Eric Nelson, Ibrahim Askar, Adrienne Carol Lahti, Nina Vanessa Kraguljac
Pubblicato in: JAMA Psychiatry, 2022, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2022.3010

Charting Brain Growth and Aging at High Spatial Precision

Autori: Rutherford, Saige, Charlotte Fraza, Richard Dinga, Seyed Mostafa Kia, Thomas Wolfers, Mariam Zabihi, Pierre Berthet, et al.
Pubblicato in: eLife, Numero e72904, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.72904

The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research

Autori: Nilakshi Vaidya, Andre F. Marquand, Frauke Nees, Sebastian Siehl, Gunter Schumann
Pubblicato in: Molecular Psychiatry, Numero 29, 2024, Pagina/e 3245-3267, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02556-y

Non-Gaussian normative modelling with hierarchical Bayesian regression

Autori: Augustijn A. A. de Boer, Johanna M. M. Bayer, Seyed Mostafa Kia, Saige Rutherford, Mariam Zabihi, Charlotte Fraza, Pieter Barkema, Lars T. Westlye, Ole A. Andreassen, Max Hinne, Christian F. Beckmann, Andre Marquand
Pubblicato in: Imaging Neuroscience, Numero 2, 2024, Pagina/e 1-36, ISSN 2837-6056
Editore: MIT Press
DOI: 10.1162/imag_a_00132

From smartphone data to clinically relevant predictions: A systematic review of digital phenotyping methods in depression

Autori: Imogen E. Leaning, Nessa Ikani, Hannah S. Savage, Alex Leow, Christian Beckmann, Henricus G. Ruhé, Andre F. Marquand
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 158, 2024, Pagina/e 105541, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105541

A stable and replicable neural signature of lifespan adversity in the adult brain

Autori: Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Pubblicato in: Nature Neuroscience, Numero 26, 2023, Pagina/e 1603–1612, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Evidence for embracing normative modeling

Autori: Saige Rutherford, Pieter Barkema, Ivy F Tso, Chandra Sripada, Christian F Beckmann, Henricus G Ruhe, Andre F Marquand
Pubblicato in: eLife, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.85082

Smartphone keyboard dynamics predict affect in suicidal ideation

Autori: Loran Knol, Anisha Nagpal, Imogen E. Leaning, Elena Idda, Faraz Hussain, Emma Ning, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Andre F. Marquand & Alex Leow
Pubblicato in: NPJ Digital Medicine, 2023, ISSN 2398-6352
Editore: Springer Nature
DOI: 10.1038/s41746-024-01048-1

Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis

Autori: Ramona Cirstian, Natalie J. Forde, Hui Zhang, Gerhard S. Hellemann, Christian F. Beckmann, Nina V. Kraguljac, Andre F. Marquand
Pubblicato in: Biological Psychiatry, 2025, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2025.07.021

Mapping cerebellar anatomical heterogeneity in mental and neurological illnesses

Autori: Milin Kim, Esten Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Christian F. Beckmann, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Pubblicato in: Nature Mental Health, Numero 2, 2024, Pagina/e 1196-1207, ISSN 2731-6076
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00297-z

Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study

Autori: Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Lianne M Reus, Pieter Jelle Visser, Martien J H Kas, Christian F Beckmann, Henricus G Ruhé, Andre F Marquand
Pubblicato in: Journal of Medical Internet Research, Numero 27, 2025, Pagina/e e64007, ISSN 1438-8871
Editore: Journal of medical Internet Research
DOI: 10.2196/64007

Neural correlates of human fear conditioning and sources of variability in 2199 individuals

Autori: Joaquim Radua, Hannah S. Savage, Enric Vilajosana, Alec Jamieson, Birgit Abler, Fredrik Åhs, Tom Beckers, Narcís Cardoner, Josh M. Cisler, Juliana B. Diniz, Dominik R. Bach, Sigrid Elsenbruch, Steven G. Greening, Daphne J. Holt, Antonia N. Kaczkurkin, Andreas Keil, Merel Kindt, Kathrin Koch, Kevin S. LaBar, Charlene L. Lam, Christine L. Larson, Tina B. Lonsdorf, Christian J. Merz, Katie A. McLau
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-63078-x

Warped Bayesian Linear Regression for Normative Modelling of Big Data

Autori: Fraza, Charlotte J., Richard Dinga, Christian F. Beckmann, and Andre F. Marquand
Pubblicato in: NeuroImage, Numero 245, 2021, Pagina/e 118715, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.118715

The promise of quantifying individual risk for brain disorders through normative modeling, a narrative review

Autori: Charlotte Fraza, Saige Rutherford, Barbora Rehák Bučková, Christian F. Beckmann, Andre F. Marquand
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 176, 2025, Pagina/e 106284, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2025.106284

Exploring brain structural effects of dopaminergic antagonism and partial agonism in antipsychotic‐naïve patients with first‐episode psychosis using normative modeling

Autori: Anna Feveile, Karen S. Ambrosen, Ketevan Shalikashvili, Jayachandra M. Raghava, Mette Ø. Nielsen, Kirsten B. Bojesen, Barbora R. Bučková, Andre F. Marquand, Birte Y. Glenthøj, Warda T. Syeda, Bjørn H. Ebdrup
Pubblicato in: Psychiatry and Clinical Neurosciences, 2026, ISSN 1323-1316
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pcn.70017

Predictive Clinical Neuroscience Portal (PCNportal): instant online access to research-grade normative models for clinical neuroscientists

Autori: Pieter Barkema, Saige Rutherford, Hurng-Chun Lee, Seyed Mostafa Kia, Hannah Savage, Christian Beckmann, Andre Marquand
Pubblicato in: Wellcome Open Research, 2023, ISSN 2398-502X
Editore: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.19591.2

Other (4)

Unobtrusive inference of diurnal rhythms from smartphone data

Autori: Loran Knol, Mindy K. Ross, Anisha Nagpal, Andrew P. Burns, Zachery D. Morrissey, Faraz Hussain, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Alex Leow, Andre F. Marquand
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2025.04.14.25325807

Do you match what I match? A systematic review of 20 years of the emotional face matching task reveals vast inconsistencies in design and implementation.

Autori: Hannah Savage, Linda Schlüter, Imogen Leaning, Christian Beckmann, null Andre
Pubblicato in: 2024
Editore: Center for Open Science
DOI: 10.31234/osf.io/m5wnq

Did you miss me? Making the most of digital phenotyping data by imputing missingness with point process models

Autori: Imogen E. Leaning, Andrea Costanzo, Raj Jagesar, Loran Knol, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Lianne M Reus, Pieter Jelle Visser, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2025.05.13.25327521

More than one piece of the puzzle: considering non-clinical factors for personalisation in digital phenotyping

Autori: Imogen E. Leaning, Linda Schlüter, Imke de Wijs, Mila Brandsen, Mila Roozen, Raj Jagesar, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2025.11.18.25340238