Integrating biology and behaviour for precision stratification of mental disorders

Información del proyecto

MENTALPRECISION

Identificador del acuerdo de subvención: 101001118

DOI

10.3030/101001118

Fecha de la firma de la CE 8 Abril 2021

Fecha de inicio 1 Junio 2021

Fecha de finalización 30 Noviembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 000 000,00

Aportación de la UE

€ 2 000 000,00

Coordinado por

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Data management plan

Publicaciones

Peer reviewed articles (31)

Functional Network Connectivity Deviation Is Associated With Transdiagnostic Symptomatology: Brain Connectivity Links to Transdiagnostic Symptoms

Autores: Josina D. Kist, Charlotte Fraza, Hannah S. Savage, Peter C.R. Mulders, Janna N. Vrijsen, Rose M. Collard, Indira Tendolkar, Philip van Eijndhoven, Andre F. Marquand
Publicado en: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Editor: Elsevier BV
DOI: 10.1016/j.bpsc.2025.09.014

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

Autores: Hannah S. Savage, Peter C. R. Mulders, Philip F. P. van Eijndhoven, Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen, Christian F. Beckmann, Andre F. Marquand
Publicado en: Communications Biology, Edición 7, 2024, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06573-z

Objective QC for diffusion MRI data: Artefact detection using normative modelling

Autores: Ramona Cirstian, Natalie J. Forde, Jesper L. R. Andersson, Stamatios N. Sotiropoulos, Christian F. Beckmann, Andre F. Marquand
Publicado en: Imaging Neuroscience, 2024, ISSN 2837-6056
Editor: MIT Press
DOI: 10.1162/imag_a_00144

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Autores: Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcís Cardoner, Jeggan Tiego, Murat Yücel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Publicado en: Nature Neuroscience, Edición 26, 2023, Página(s) 1613–1629, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-023-01404-6

Using normative models pre-trained on cross-sectional data to evaluate intra-individual longitudinal changes in neuroimaging data

Autores: Barbora Rehak Buckova, Charlotte Fraza, Rastislav Rehák, Marián Kolenič, Christian F Beckmann, Filip Španiel, Andre F Marquand, Jaroslav Hlinka
Publicado en: eLife, Edición 13, 2025, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.95823.4

Closing the Life-Cycle of Normative Modeling Using Federated Hierarchical Bayesian Regression

Autores: Kia, Seyed Mostafa, Hester Huijsdens, Saige Rutherford, Augustijn de Boer, Richard Dinga, Thomas Wolfers, Pierre Berthet, et al
Publicado en: PLOS ONE, 2022, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0278776

Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features

Autores: Milin Kim, Nitin Sharma, Esten H. Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Aikaterina Manoli, Sofie L. Valk, Dag Alnæs, Christian F. Beckman, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Publicado en: Biological Psychiatry Global Open Science, 2025, ISSN 2667-1743
Editor: Elsevier
DOI: 10.1101/2024.12.10.24318590

Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth

Autores: Rikka Kjelkenes, Thomas Wolfers, Dag Alnæs, Dennis van der Meer, Mads Lund Pedersen, Andreas Dahl, Irene Voldsbekk, Torgeir Moberget, Christian K Tamnes, Ole A Andreassen, Andre F Marquand, Lars T Westlye
Publicado en: Biology Psychiatry Global Open Science, 2023, ISSN 2667-1743
Editor: Elsevier
DOI: 10.1016/j.bpsgos.2022.01.007

Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model

Autores: Charlotte Fraza, Mariam Zabihi, Christian F. Beckmann, Andre F. Marquand
Publicado en: Human Brain Mapping, Edición 46, 2025, ISSN 1065-9471
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hbm.70281

Understanding individual neurodegenerative progression in Parkinson’s disease through normative modelling

Autores: Charlotte Fraza, Barbora Rehák Bučková, Martin E. Johansson, Rick C. Helmich, Andre F. Marquand, Christian F. Beckmann
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-20484-x

Framework for Brain-Derived Dimensions of Psychopathology

Autores: Tristram A. Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Argyris Stringaris, Lea Waller, Zuo Zhang, Jeanne Wintere
Publicado en: JAMA Psychiatry, Edición 82, 2025, Página(s) 778, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2025.1246

Striatal Connectopic Maps Link to Functional Domains across Psychiatric Disorders’

Autores: Mulders, Peter C. R., Philip F. P. van Eijndhoven, Jasper van Oort, Marianne Oldehinkel, Fleur A. Duyser, Josina D. Kist, Rose M. Collard, et al
Publicado en: Translational Psychiatry, 2022, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-022-02273-6

Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models

Autores: Johanna M.M. Bayer, Richard Dinga, Seyed Mostafa Kia, Akhil R. Kottaram, Thomas Wolfers, Jinglei Lv, Andrew Zalesky, Lianne Schmaal, Andre Marquand
Publicado en: Neuroimage, 2022, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2022.119699

Unraveling the link between CNVs, cognition and individual neuroimaging deviation scores from a population-based reference cohort

Autores: Charlotte Fraza, Ida E. Sønderby, Rune Boen, Yingjie Shi, Christian F. Beckmann, Andre F. Marquand
Publicado en: Nature Mental Health, Edición 2, 2024, Página(s) 1451-1463, ISSN 2731-6076
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00322-1

The normative modeling framework for computational psychiatry

Autores: Saige Rutherford, Seyed Mostafa Kia, Thomas Wolfers, Charlotte Fraza, Mariam Zabihi, Richard Dinga, Pierre Berthet, Amanda Worker, Serena Verdi, Henricus G. Ruhe, Christian F. Beckmann & Andre F. Marquand
Publicado en: Nature Protocols, Edición 17, 2022, Página(s) 1711–1734, ISSN 1750-2799
Editor: Springer Nature
DOI: 10.1038/s41596-022-00696-5

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive

Autores: Natalie Remiszewski, James Edward Bryant, Saige E. Rutherford, Andre F. Marquand, Eric Nelson, Ibrahim Askar, Adrienne Carol Lahti, Nina Vanessa Kraguljac
Publicado en: JAMA Psychiatry, 2022, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2022.3010

Charting Brain Growth and Aging at High Spatial Precision

Autores: Rutherford, Saige, Charlotte Fraza, Richard Dinga, Seyed Mostafa Kia, Thomas Wolfers, Mariam Zabihi, Pierre Berthet, et al.
Publicado en: eLife, Edición e72904, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.72904

The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research

Autores: Nilakshi Vaidya, Andre F. Marquand, Frauke Nees, Sebastian Siehl, Gunter Schumann
Publicado en: Molecular Psychiatry, Edición 29, 2024, Página(s) 3245-3267, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-024-02556-y

Non-Gaussian normative modelling with hierarchical Bayesian regression

Autores: Augustijn A. A. de Boer, Johanna M. M. Bayer, Seyed Mostafa Kia, Saige Rutherford, Mariam Zabihi, Charlotte Fraza, Pieter Barkema, Lars T. Westlye, Ole A. Andreassen, Max Hinne, Christian F. Beckmann, Andre Marquand
Publicado en: Imaging Neuroscience, Edición 2, 2024, Página(s) 1-36, ISSN 2837-6056
Editor: MIT Press
DOI: 10.1162/imag_a_00132

From smartphone data to clinically relevant predictions: A systematic review of digital phenotyping methods in depression

Autores: Imogen E. Leaning, Nessa Ikani, Hannah S. Savage, Alex Leow, Christian Beckmann, Henricus G. Ruhé, Andre F. Marquand
Publicado en: Neuroscience & Biobehavioral Reviews, Edición 158, 2024, Página(s) 105541, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105541

A stable and replicable neural signature of lifespan adversity in the adult brain

Autores: Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Publicado en: Nature Neuroscience, Edición 26, 2023, Página(s) 1603–1612, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Evidence for embracing normative modeling

Autores: Saige Rutherford, Pieter Barkema, Ivy F Tso, Chandra Sripada, Christian F Beckmann, Henricus G Ruhe, Andre F Marquand
Publicado en: eLife, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.85082

Smartphone keyboard dynamics predict affect in suicidal ideation

Autores: Loran Knol, Anisha Nagpal, Imogen E. Leaning, Elena Idda, Faraz Hussain, Emma Ning, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Andre F. Marquand & Alex Leow
Publicado en: NPJ Digital Medicine, 2023, ISSN 2398-6352
Editor: Springer Nature
DOI: 10.1038/s41746-024-01048-1

Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis

Autores: Ramona Cirstian, Natalie J. Forde, Hui Zhang, Gerhard S. Hellemann, Christian F. Beckmann, Nina V. Kraguljac, Andre F. Marquand
Publicado en: Biological Psychiatry, 2025, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2025.07.021

Mapping cerebellar anatomical heterogeneity in mental and neurological illnesses

Autores: Milin Kim, Esten Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Christian F. Beckmann, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Publicado en: Nature Mental Health, Edición 2, 2024, Página(s) 1196-1207, ISSN 2731-6076
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00297-z

Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study

Autores: Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Lianne M Reus, Pieter Jelle Visser, Martien J H Kas, Christian F Beckmann, Henricus G Ruhé, Andre F Marquand
Publicado en: Journal of Medical Internet Research, Edición 27, 2025, Página(s) e64007, ISSN 1438-8871
Editor: Journal of medical Internet Research
DOI: 10.2196/64007

Neural correlates of human fear conditioning and sources of variability in 2199 individuals

Autores: Joaquim Radua, Hannah S. Savage, Enric Vilajosana, Alec Jamieson, Birgit Abler, Fredrik Åhs, Tom Beckers, Narcís Cardoner, Josh M. Cisler, Juliana B. Diniz, Dominik R. Bach, Sigrid Elsenbruch, Steven G. Greening, Daphne J. Holt, Antonia N. Kaczkurkin, Andreas Keil, Merel Kindt, Kathrin Koch, Kevin S. LaBar, Charlene L. Lam, Christine L. Larson, Tina B. Lonsdorf, Christian J. Merz, Katie A. McLau
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-63078-x

Warped Bayesian Linear Regression for Normative Modelling of Big Data

Autores: Fraza, Charlotte J., Richard Dinga, Christian F. Beckmann, and Andre F. Marquand
Publicado en: NeuroImage, Edición 245, 2021, Página(s) 118715, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2021.118715

The promise of quantifying individual risk for brain disorders through normative modeling, a narrative review

Autores: Charlotte Fraza, Saige Rutherford, Barbora Rehák Bučková, Christian F. Beckmann, Andre F. Marquand
Publicado en: Neuroscience & Biobehavioral Reviews, Edición 176, 2025, Página(s) 106284, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2025.106284

Exploring brain structural effects of dopaminergic antagonism and partial agonism in antipsychotic‐naïve patients with first‐episode psychosis using normative modeling

Autores: Anna Feveile, Karen S. Ambrosen, Ketevan Shalikashvili, Jayachandra M. Raghava, Mette Ø. Nielsen, Kirsten B. Bojesen, Barbora R. Bučková, Andre F. Marquand, Birte Y. Glenthøj, Warda T. Syeda, Bjørn H. Ebdrup
Publicado en: Psychiatry and Clinical Neurosciences, 2026, ISSN 1323-1316
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pcn.70017

Predictive Clinical Neuroscience Portal (PCNportal): instant online access to research-grade normative models for clinical neuroscientists

Autores: Pieter Barkema, Saige Rutherford, Hurng-Chun Lee, Seyed Mostafa Kia, Hannah Savage, Christian Beckmann, Andre Marquand
Publicado en: Wellcome Open Research, 2023, ISSN 2398-502X
Editor: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.19591.2

Other (4)

Unobtrusive inference of diurnal rhythms from smartphone data

Autores: Loran Knol, Mindy K. Ross, Anisha Nagpal, Andrew P. Burns, Zachery D. Morrissey, Faraz Hussain, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Alex Leow, Andre F. Marquand
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.04.14.25325807

Do you match what I match? A systematic review of 20 years of the emotional face matching task reveals vast inconsistencies in design and implementation.

Autores: Hannah Savage, Linda Schlüter, Imogen Leaning, Christian Beckmann, null Andre
Publicado en: 2024
Editor: Center for Open Science
DOI: 10.31234/osf.io/m5wnq

Did you miss me? Making the most of digital phenotyping data by imputing missingness with point process models

Autores: Imogen E. Leaning, Andrea Costanzo, Raj Jagesar, Loran Knol, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Lianne M Reus, Pieter Jelle Visser, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.05.13.25327521

More than one piece of the puzzle: considering non-clinical factors for personalisation in digital phenotyping

Autores: Imogen E. Leaning, Linda Schlüter, Imke de Wijs, Mila Brandsen, Mila Roozen, Raj Jagesar, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.11.18.25340238