Integrating biology and behaviour for precision stratification of mental disorders

Informacje na temat projektu

MENTALPRECISION

Identyfikator umowy o grant: 101001118

DOI

10.3030/101001118

Data podpisania przez KE 8 Kwietnia 2021

Data rozpoczęcia 1 Czerwca 2021

Data zakończenia 30 Listopada 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 000 000,00

Wkład UE

€ 2 000 000,00

Koordynowany przez

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Open Research Data Pilot (1)

Data Management Plan

Data management plan

Publikacje

Peer reviewed articles (31)

Functional Network Connectivity Deviation Is Associated With Transdiagnostic Symptomatology: Brain Connectivity Links to Transdiagnostic Symptoms

Autorzy: Josina D. Kist, Charlotte Fraza, Hannah S. Savage, Peter C.R. Mulders, Janna N. Vrijsen, Rose M. Collard, Indira Tendolkar, Philip van Eijndhoven, Andre F. Marquand
Opublikowane w: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Wydawca: Elsevier BV
DOI: 10.1016/j.bpsc.2025.09.014

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

Autorzy: Hannah S. Savage, Peter C. R. Mulders, Philip F. P. van Eijndhoven, Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen, Christian F. Beckmann, Andre F. Marquand
Opublikowane w: Communications Biology, Numer 7, 2024, ISSN 2399-3642
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06573-z

Objective QC for diffusion MRI data: Artefact detection using normative modelling

Autorzy: Ramona Cirstian, Natalie J. Forde, Jesper L. R. Andersson, Stamatios N. Sotiropoulos, Christian F. Beckmann, Andre F. Marquand
Opublikowane w: Imaging Neuroscience, 2024, ISSN 2837-6056
Wydawca: MIT Press
DOI: 10.1162/imag_a_00144

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Autorzy: Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcís Cardoner, Jeggan Tiego, Murat Yücel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Opublikowane w: Nature Neuroscience, Numer 26, 2023, Strona(/y) 1613–1629, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-023-01404-6

Using normative models pre-trained on cross-sectional data to evaluate intra-individual longitudinal changes in neuroimaging data

Autorzy: Barbora Rehak Buckova, Charlotte Fraza, Rastislav Rehák, Marián Kolenič, Christian F Beckmann, Filip Španiel, Andre F Marquand, Jaroslav Hlinka
Opublikowane w: eLife, Numer 13, 2025, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.95823.4

Closing the Life-Cycle of Normative Modeling Using Federated Hierarchical Bayesian Regression

Autorzy: Kia, Seyed Mostafa, Hester Huijsdens, Saige Rutherford, Augustijn de Boer, Richard Dinga, Thomas Wolfers, Pierre Berthet, et al
Opublikowane w: PLOS ONE, 2022, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0278776

Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features

Autorzy: Milin Kim, Nitin Sharma, Esten H. Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Aikaterina Manoli, Sofie L. Valk, Dag Alnæs, Christian F. Beckman, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Opublikowane w: Biological Psychiatry Global Open Science, 2025, ISSN 2667-1743
Wydawca: Elsevier
DOI: 10.1101/2024.12.10.24318590

Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth

Autorzy: Rikka Kjelkenes, Thomas Wolfers, Dag Alnæs, Dennis van der Meer, Mads Lund Pedersen, Andreas Dahl, Irene Voldsbekk, Torgeir Moberget, Christian K Tamnes, Ole A Andreassen, Andre F Marquand, Lars T Westlye
Opublikowane w: Biology Psychiatry Global Open Science, 2023, ISSN 2667-1743
Wydawca: Elsevier
DOI: 10.1016/j.bpsgos.2022.01.007

Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model

Autorzy: Charlotte Fraza, Mariam Zabihi, Christian F. Beckmann, Andre F. Marquand
Opublikowane w: Human Brain Mapping, Numer 46, 2025, ISSN 1065-9471
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hbm.70281

Understanding individual neurodegenerative progression in Parkinson’s disease through normative modelling

Autorzy: Charlotte Fraza, Barbora Rehák Bučková, Martin E. Johansson, Rick C. Helmich, Andre F. Marquand, Christian F. Beckmann
Opublikowane w: Scientific Reports, Numer 15, 2025, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-025-20484-x

Framework for Brain-Derived Dimensions of Psychopathology

Autorzy: Tristram A. Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Argyris Stringaris, Lea Waller, Zuo Zhang, Jeanne Wintere
Opublikowane w: JAMA Psychiatry, Numer 82, 2025, Strona(/y) 778, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2025.1246

Striatal Connectopic Maps Link to Functional Domains across Psychiatric Disorders’

Autorzy: Mulders, Peter C. R., Philip F. P. van Eijndhoven, Jasper van Oort, Marianne Oldehinkel, Fleur A. Duyser, Josina D. Kist, Rose M. Collard, et al
Opublikowane w: Translational Psychiatry, 2022, ISSN 2158-3188
Wydawca: Nature Publishing Group
DOI: 10.1038/s41398-022-02273-6

Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models

Autorzy: Johanna M.M. Bayer, Richard Dinga, Seyed Mostafa Kia, Akhil R. Kottaram, Thomas Wolfers, Jinglei Lv, Andrew Zalesky, Lianne Schmaal, Andre Marquand
Opublikowane w: Neuroimage, 2022, ISSN 1053-8119
Wydawca: Academic Press
DOI: 10.1016/j.neuroimage.2022.119699

Unraveling the link between CNVs, cognition and individual neuroimaging deviation scores from a population-based reference cohort

Autorzy: Charlotte Fraza, Ida E. Sønderby, Rune Boen, Yingjie Shi, Christian F. Beckmann, Andre F. Marquand
Opublikowane w: Nature Mental Health, Numer 2, 2024, Strona(/y) 1451-1463, ISSN 2731-6076
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00322-1

The normative modeling framework for computational psychiatry

Autorzy: Saige Rutherford, Seyed Mostafa Kia, Thomas Wolfers, Charlotte Fraza, Mariam Zabihi, Richard Dinga, Pierre Berthet, Amanda Worker, Serena Verdi, Henricus G. Ruhe, Christian F. Beckmann & Andre F. Marquand
Opublikowane w: Nature Protocols, Numer 17, 2022, Strona(/y) 1711–1734, ISSN 1750-2799
Wydawca: Springer Nature
DOI: 10.1038/s41596-022-00696-5

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive

Autorzy: Natalie Remiszewski, James Edward Bryant, Saige E. Rutherford, Andre F. Marquand, Eric Nelson, Ibrahim Askar, Adrienne Carol Lahti, Nina Vanessa Kraguljac
Opublikowane w: JAMA Psychiatry, 2022, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2022.3010

Charting Brain Growth and Aging at High Spatial Precision

Autorzy: Rutherford, Saige, Charlotte Fraza, Richard Dinga, Seyed Mostafa Kia, Thomas Wolfers, Mariam Zabihi, Pierre Berthet, et al.
Opublikowane w: eLife, Numer e72904, 2022, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.72904

The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research

Autorzy: Nilakshi Vaidya, Andre F. Marquand, Frauke Nees, Sebastian Siehl, Gunter Schumann
Opublikowane w: Molecular Psychiatry, Numer 29, 2024, Strona(/y) 3245-3267, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-024-02556-y

Non-Gaussian normative modelling with hierarchical Bayesian regression

Autorzy: Augustijn A. A. de Boer, Johanna M. M. Bayer, Seyed Mostafa Kia, Saige Rutherford, Mariam Zabihi, Charlotte Fraza, Pieter Barkema, Lars T. Westlye, Ole A. Andreassen, Max Hinne, Christian F. Beckmann, Andre Marquand
Opublikowane w: Imaging Neuroscience, Numer 2, 2024, Strona(/y) 1-36, ISSN 2837-6056
Wydawca: MIT Press
DOI: 10.1162/imag_a_00132

From smartphone data to clinically relevant predictions: A systematic review of digital phenotyping methods in depression

Autorzy: Imogen E. Leaning, Nessa Ikani, Hannah S. Savage, Alex Leow, Christian Beckmann, Henricus G. Ruhé, Andre F. Marquand
Opublikowane w: Neuroscience & Biobehavioral Reviews, Numer 158, 2024, Strona(/y) 105541, ISSN 0149-7634
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105541

A stable and replicable neural signature of lifespan adversity in the adult brain

Autorzy: Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Opublikowane w: Nature Neuroscience, Numer 26, 2023, Strona(/y) 1603–1612, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Evidence for embracing normative modeling

Autorzy: Saige Rutherford, Pieter Barkema, Ivy F Tso, Chandra Sripada, Christian F Beckmann, Henricus G Ruhe, Andre F Marquand
Opublikowane w: eLife, 2023, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.85082

Smartphone keyboard dynamics predict affect in suicidal ideation

Autorzy: Loran Knol, Anisha Nagpal, Imogen E. Leaning, Elena Idda, Faraz Hussain, Emma Ning, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Andre F. Marquand & Alex Leow
Opublikowane w: NPJ Digital Medicine, 2023, ISSN 2398-6352
Wydawca: Springer Nature
DOI: 10.1038/s41746-024-01048-1

Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis

Autorzy: Ramona Cirstian, Natalie J. Forde, Hui Zhang, Gerhard S. Hellemann, Christian F. Beckmann, Nina V. Kraguljac, Andre F. Marquand
Opublikowane w: Biological Psychiatry, 2025, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2025.07.021

Mapping cerebellar anatomical heterogeneity in mental and neurological illnesses

Autorzy: Milin Kim, Esten Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Christian F. Beckmann, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget
Opublikowane w: Nature Mental Health, Numer 2, 2024, Strona(/y) 1196-1207, ISSN 2731-6076
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00297-z

Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study

Autorzy: Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Lianne M Reus, Pieter Jelle Visser, Martien J H Kas, Christian F Beckmann, Henricus G Ruhé, Andre F Marquand
Opublikowane w: Journal of Medical Internet Research, Numer 27, 2025, Strona(/y) e64007, ISSN 1438-8871
Wydawca: Journal of medical Internet Research
DOI: 10.2196/64007

Neural correlates of human fear conditioning and sources of variability in 2199 individuals

Autorzy: Joaquim Radua, Hannah S. Savage, Enric Vilajosana, Alec Jamieson, Birgit Abler, Fredrik Åhs, Tom Beckers, Narcís Cardoner, Josh M. Cisler, Juliana B. Diniz, Dominik R. Bach, Sigrid Elsenbruch, Steven G. Greening, Daphne J. Holt, Antonia N. Kaczkurkin, Andreas Keil, Merel Kindt, Kathrin Koch, Kevin S. LaBar, Charlene L. Lam, Christine L. Larson, Tina B. Lonsdorf, Christian J. Merz, Katie A. McLau
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-63078-x

Warped Bayesian Linear Regression for Normative Modelling of Big Data

Autorzy: Fraza, Charlotte J., Richard Dinga, Christian F. Beckmann, and Andre F. Marquand
Opublikowane w: NeuroImage, Numer 245, 2021, Strona(/y) 118715, ISSN 1053-8119
Wydawca: Academic Press
DOI: 10.1016/j.neuroimage.2021.118715

The promise of quantifying individual risk for brain disorders through normative modeling, a narrative review

Autorzy: Charlotte Fraza, Saige Rutherford, Barbora Rehák Bučková, Christian F. Beckmann, Andre F. Marquand
Opublikowane w: Neuroscience & Biobehavioral Reviews, Numer 176, 2025, Strona(/y) 106284, ISSN 0149-7634
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2025.106284

Exploring brain structural effects of dopaminergic antagonism and partial agonism in antipsychotic‐naïve patients with first‐episode psychosis using normative modeling

Autorzy: Anna Feveile, Karen S. Ambrosen, Ketevan Shalikashvili, Jayachandra M. Raghava, Mette Ø. Nielsen, Kirsten B. Bojesen, Barbora R. Bučková, Andre F. Marquand, Birte Y. Glenthøj, Warda T. Syeda, Bjørn H. Ebdrup
Opublikowane w: Psychiatry and Clinical Neurosciences, 2026, ISSN 1323-1316
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/pcn.70017

Predictive Clinical Neuroscience Portal (PCNportal): instant online access to research-grade normative models for clinical neuroscientists

Autorzy: Pieter Barkema, Saige Rutherford, Hurng-Chun Lee, Seyed Mostafa Kia, Hannah Savage, Christian Beckmann, Andre Marquand
Opublikowane w: Wellcome Open Research, 2023, ISSN 2398-502X
Wydawca: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.19591.2

Other (4)

Unobtrusive inference of diurnal rhythms from smartphone data

Autorzy: Loran Knol, Mindy K. Ross, Anisha Nagpal, Andrew P. Burns, Zachery D. Morrissey, Faraz Hussain, Tory A. Eisenlohr-Moul, Christian F. Beckmann, Alex Leow, Andre F. Marquand
Opublikowane w: 2026
Wydawca: openRxiv
DOI: 10.1101/2025.04.14.25325807

Do you match what I match? A systematic review of 20 years of the emotional face matching task reveals vast inconsistencies in design and implementation.

Autorzy: Hannah Savage, Linda Schlüter, Imogen Leaning, Christian Beckmann, null Andre
Opublikowane w: 2024
Wydawca: Center for Open Science
DOI: 10.31234/osf.io/m5wnq

Did you miss me? Making the most of digital phenotyping data by imputing missingness with point process models

Autorzy: Imogen E. Leaning, Andrea Costanzo, Raj Jagesar, Loran Knol, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Lianne M Reus, Pieter Jelle Visser, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Opublikowane w: 2026
Wydawca: openRxiv
DOI: 10.1101/2025.05.13.25327521

More than one piece of the puzzle: considering non-clinical factors for personalisation in digital phenotyping

Autorzy: Imogen E. Leaning, Linda Schlüter, Imke de Wijs, Mila Brandsen, Mila Roozen, Raj Jagesar, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Martien J.H. Kas, Christian F. Beckmann, Henricus G. Ruhé, Andre F. Marquand
Opublikowane w: 2026
Wydawca: openRxiv
DOI: 10.1101/2025.11.18.25340238