Descripción del proyecto
Descubrir los secretos de la memoria en el encéfalo
El encéfalo encierra muchos misterios sin resolver, uno de los cuales es el almacenamiento y la recuperación de la memoria. Usando métodos nuevos de imagenología óptica, análisis de datos a gran escala y manipulación de circuitos, el proyecto financiado con fondos europeos DYNAMIC_ENGRAM examinará los mecanismos que controlan la reorganización de la memoria, arrojando luz sobre los factores que rigen la dinámica de circuitos de las representaciones de la memoria. El trabajo del proyecto permitirá conocer la manera en que se consigue la consolidación a escala de sistemas a nivel del código neuronal y cómo se mantiene la memoria estable a largo plazo pese a los cambios constantes en la representación neuronal.
Objetivo
How does the brain store and retrieve information over time? The accepted notion that these processes rely on the neuronal ensembles that were active during learning is now challenged by findings by our lab and others that reveal that different neurons and networks than those that were active during learning support persistent memory. Most notably, we found that the long-term persistence of spatial memory is correlated with the degree to which neuronal activity is spatially informative, but not with the stability of the coding carried by individual neurons. These discoveries—obtained via novel imaging technologies that enable, for the first time, to track large populations of the same neurons over weeks—expose a fundamental gap in our understanding and highlight the need to reveal how neural codes across brain circuits, including the hippocampus, entorhinal cortex, and prefrontal cortex, change over the lifetime of a memory.
Here we propose to investigate the mechanisms that govern the reorganization of memory using innovative methods we recently developed for optical imaging, large-scale data analysis, and circuit manipulation. Key among them is our ability to simultaneously and longitudinally image in two related brain areas the activity of large neuronal populations in freely behaving mice. Using these new tools, we will elucidate the factors governing the circuit dynamics of memory representations (Aim 1); how such dynamics relate to the behavioral manifestation of memory (Aim 2); how hippocampal-cortical and cortical-cortical interactions change over weeks to support remote memory (Aim 3); and what mechanisms could underlie the transfer of learned information between neurons in a network (Aim 4).
Our approach will allow us to resolve how systems-level consolidation is realized at the neural code level, both within and across brain areas, and how a stable memory is maintained over the long term despite an ever-changing neuronal representation.
Palabras clave
Programa(s)
Régimen de financiación
ERC-COG - Consolidator GrantInstitución de acogida
7610001 Rehovot
Israel