Cyclic Peptide Platform as an Approach to Target Validation

Project Information

CPTarget

Grant agreement ID: 101003111

DOI

10.3030/101003111

EC signature date 27 January 2021

Start date 1 October 2021

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 241 271,00

EU contribution

€ 2 241 271,00

Coordinated by

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

Author(s): Oliver D. Coleman, Jessica Macdonald, Ben Thomson, Jennifer A. Ward, Christopher J. Stubbs, Tom E. McAllister, Shane Clark, Siddique Amin, Yimang Cao, Martine I. Abboud, Yijia Zhang, Hitesh Sanganee, Kilian V. M. Huber, Tim D. W. Claridge, Akane Kawamura
Published in: Chemical Science, 2023, Page(s) 7136-7146, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc05944d

Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling

Author(s): Klemensas Šimelis; Hilal Saraç; Eidarus Salah; Kosuke Nishio; Tom E. McAllister; Thomas P. Corner; Anthony Tumber; Roman Belle; Christopher J. Schofield; Hiroaki Suga; Akane Kawamura
Published in: Bioorganic & Medicinal Chemistry, Issue Volume 99, 2024, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2024.117597

The influence of degree of labelling upon cellular internalisation of antibody-cell penetrating peptide conjugates.

Author(s): Toni A. Pringle; Oliver Coleman; Akane Kawamura; James C. Knight
Published in: RSC Advances, 2022, ISSN 1473-7604
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ra05274a

Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate

Author(s): Roman Belle; Hilal Saraç; Eidarus Salah; Bhaskar Bhushan; Aleksandra Szykowska; Grace Roper; Anthony Tumber; Skirmantas Kriaucionis; Nicola Burgess-Brown; Christopher J. Schofield; Tom Brown; Akane Kawamura
Published in: Journal of Medicinal Chemistry, Issue 67 (6), 2024, Page(s) 4525-4540, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c01820

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

Author(s): Takashi Miura; Tika R. Malla; C. David Owen; Anthony Tumber; Lennart Brewitz; Michael A. McDonough; Eidarus Salah; Naohiro Terasaka; Takayuki Katoh; Petra Lukacik; Claire Strain-Damerell; Halina Mikolajek; Martin A. Walsh, Akane Kawamura; Christopher J. Schofield; Hiroaki Suga;
Published in: Nature Chemistry, 2023, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-023-01205-1

Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis

Author(s): Thomas P. Smith; Bhaskar Bhushan; Daniele Granata; Christian S. Kaas; Birgitte Andersen; Klaas W. Decoene; Qiansheng Ren; Haimo Liu; Xinping Qu; Yang Yang; Jia Pan; Quijia Chen; Martin Münzel; Akane Kawamura
Published in: RSC Chemical Biology, Issue Volume 5, Issue 1, 2024, Page(s) 1-64, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cb00168g

Fragment expansion with NUDELs - poised DNA-encoded libraries

Author(s): Catherine LA Salvini, Benoit Darlot, Jack Davison, Mathew Martin, Susan Tudhope, Shannon Turberville, Akane Kawamura, Martin EM Noble, Stephen Wedge, James John Crawford, Michael James Waring,
Published in: Chemical Science, 2023, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc01171b