Cyclic Peptide Platform as an Approach to Target Validation

Informazioni relative al progetto

CPTarget

ID dell’accordo di sovvenzione: 101003111

DOI

10.3030/101003111

Data della firma CE 27 Gennaio 2021

Data di avvio 1 Ottobre 2021

Data di completamento 31 Marzo 2028

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 241 271,00

Contributo UE

€ 2 241 271,00

Coordinato da

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (11)

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

Autori: Oliver D. Coleman, Jessica Macdonald, Ben Thomson, Jennifer A. Ward, Christopher J. Stubbs, Tom E. McAllister, Shane Clark, Siddique Amin, Yimang Cao, Martine I. Abboud, Yijia Zhang, Hitesh Sanganee, Kilian V. M. Huber, Tim D. W. Claridge, Akane Kawamura
Pubblicato in: Chemical Science, 2023, Pagina/e 7136-7146, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sc05944d

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity

Autori: Jasmine K. Bickel, Ammar. I. S. Ahmed, Aidan B. Pidd, Rhodri M. Morgan, Tom E. McAllister, Sam Horrell, Emma C. Couves, Hemavathi Nagaraj, Edward J. Bartlett, Kamel El Omari, Akane Kawamura, Doryen Bubeck, Edward W. Tate
Pubblicato in: Angewandte Chemie, Numero 137, 2026, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ange.202422673

Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling

Autori: Klemensas Šimelis; Hilal Saraç; Eidarus Salah; Kosuke Nishio; Tom E. McAllister; Thomas P. Corner; Anthony Tumber; Roman Belle; Christopher J. Schofield; Hiroaki Suga; Akane Kawamura
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero Volume 99, 2024, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2024.117597

Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes

Autori: Klemensas Šimelis, Roman Belle, Akane Kawamura
Pubblicato in: Communications Chemistry, Numero 7, 2024, ISSN 2399-3669
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42004-024-01382-1

KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9

Autori: Roman Belle, John-Paul Bukowski, Rachel Schiller, Ronald Cutler, Eidarus Salah, Robert S. Dawber, Anthony Tumber, Joanna Bonnici, Jessica D. Kindrick, Loane Serrano, Patrick Rabe, Catrine Johansson, Marie-Hélène Ruchaud, Richard J. Hopkinson, William D. Figg, Sr, Paul E. Brennan, David R. Mole, Simone Sidoli, Akane Kawamura, Christopher J. Schofield
Pubblicato in: Nature Chemistry, Numero 18, 2026, Pagina/e 823-834, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-026-02112-x

Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease

Autori: Takashi Miura, Tika R Malla, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Kang Ju Lee, Naohiro Terasaka, C David Owen, Claire Strain-Damerell, Petra Lukacik, Martin A Walsh, Akane Kawamura, Christopher J Schofield, Takayuki Katoh, Hiroaki Suga
Pubblicato in: Bulletin of the Chemical Society of Japan, Numero 97, 2024, ISSN 0009-2673
Editore: Chemical Society of Japan/Nippon Kagakukai
DOI: 10.1093/bulcsj/uoae018

The influence of degree of labelling upon cellular internalisation of antibody-cell penetrating peptide conjugates.

Autori: Toni A. Pringle; Oliver Coleman; Akane Kawamura; James C. Knight
Pubblicato in: RSC Advances, 2022, ISSN 1473-7604
Editore: Royal Society of Chemistry
DOI: 10.1039/d2ra05274a

Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate

Autori: Roman Belle; Hilal Saraç; Eidarus Salah; Bhaskar Bhushan; Aleksandra Szykowska; Grace Roper; Anthony Tumber; Skirmantas Kriaucionis; Nicola Burgess-Brown; Christopher J. Schofield; Tom Brown; Akane Kawamura
Pubblicato in: Journal of Medicinal Chemistry, Numero 67 (6), 2024, Pagina/e 4525-4540, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c01820

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

Autori: Takashi Miura; Tika R. Malla; C. David Owen; Anthony Tumber; Lennart Brewitz; Michael A. McDonough; Eidarus Salah; Naohiro Terasaka; Takayuki Katoh; Petra Lukacik; Claire Strain-Damerell; Halina Mikolajek; Martin A. Walsh, Akane Kawamura; Christopher J. Schofield; Hiroaki Suga;
Pubblicato in: Nature Chemistry, 2023, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-023-01205-1

Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis

Autori: Thomas P. Smith; Bhaskar Bhushan; Daniele Granata; Christian S. Kaas; Birgitte Andersen; Klaas W. Decoene; Qiansheng Ren; Haimo Liu; Xinping Qu; Yang Yang; Jia Pan; Quijia Chen; Martin Münzel; Akane Kawamura
Pubblicato in: RSC Chemical Biology, Numero Volume 5, Numero 1, 2024, Pagina/e 1-64, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cb00168g

Fragment expansion with NUDELs - poised DNA-encoded libraries

Autori: Catherine LA Salvini, Benoit Darlot, Jack Davison, Mathew Martin, Susan Tudhope, Shannon Turberville, Akane Kawamura, Martin EM Noble, Stephen Wedge, James John Crawford, Michael James Waring,
Pubblicato in: Chemical Science, 2023, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc01171b