Descrizione del progetto
Tossine emergenti nelle acque del Portogallo
Negli ultimi anni, sono state individuate nelle acque costiere dell’Unione europea (UE) tossine provenienti da ambienti tropicali. Questa situazione richiede ulteriori programmi di monitoraggio, una legislazione rafforzata e metodi per l’analisi delle tossine. Tuttavia, a causa dei dati quantitativi e della metodologia analitica limitati, è impossibile determinare il rischio associato all’esposizione delle tossine emergenti nell’UE. Il progetto ETOXPT, finanziato dall’UE, si propone di valutare la situazione attuale lungo le coste del Portogallo attraverso metodi affidabili di cromatografia liquida-spettrometria di massa/spettrometria di massa. Il progetto agevolerà lo sviluppo di modelli predittivi di valutazione del rischio, contribuendo all’integrazione delle tossine emergenti nei programmi di monitoraggio dei crostacei.
Obiettivo
The occurrence of toxins typical from tropical environments in European Union (EU) temperate coastal waters has been sporadically reported in the past years, usually preceded by human intoxication episodes. Therefore, in order to avoid public health impacts, there is a need for adequate monitoring programs, establishing appropriate legislation, and for optimizing effective methods for the analysis of these toxins. However, due to the very limited quantitative data and the lack of validated analytical methodology, risk associated with the exposure to emergent toxins in EU is currently not possible to determine. In ETOXPT, we will assess the current situation on the incidence and routes of exposure of emergent toxins (i.e. ciguatoxins, CTXs; tetrodotoxin, TTX; palytoxins, PLTXs; and ß-methylamino-L-alanine, BMAA) in Portuguese coastal waters using reliable LC-MS/MS methods. Additionally, the relationship of emergent toxins concentrations and profiles within trophic levels will be evaluated. These field data will be complemented with a mesocosm experiment, in which the potential of CTXs transfer, biotransformation and biodegradation along the food web will be predicted. We will also evaluate the cytotoxicity of individual PLTXs and CTXs analogues. Concurrently, we will develop innovative approaches to analyze the emergent toxins using nanocontainers. ETOXPT will be useful to advance understanding of emergent toxins kinetics, both within individuals and among trophic levels and could support the development of predictive models of risk assessment and contribute to the integration of emergent toxins in shellfish monitoring programs.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
8005-139 FARO
Portogallo