MOlecular-Scale Biophysics Research Infrastructure

Project Information

MOSBRI

Grant agreement ID: 101004806

DOI

10.3030/101004806

EC signature date 16 March 2021

Start date 1 July 2021

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - Research Infrastructures

Total cost

€ 4 996 058,14

EU contribution

€ 4 996 058,00

Coordinated by

INSTITUT PASTEUR
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (4)

Dissemination of novel methodologies via website

Dissemination of novel methodologies via websiteDeliverable to be submitted in M12 M24 and M48

Operational proposal system based on ARIA cloud service
Driving licence specifications and test materials at Operator level
MOSBRI website

Documents, reports (5)

Report on joint events organized with ARBRE and EBSA

Report on joint events organized with ARBRE and EBSADeliverable to be submitted in M18 M30 and M42

Analysis of the mapping of the needs for data standards/formats

Analysis of the mapping of the needs for data standardsformats

Established reference calibration samples
Analysis of the mapping of the needs for repository/database

Analysis of the mapping of the needs for repositorydatabase

Report on joint events organized with INSTRUCT

Report on joint events organized with INSTRUCTDeliverable to be submitted in M18 M30 and M42

Other (1)

Setting-up of a TNA moderator panel and of a TNA reviewer panel

Publications

Peer reviewed articles (34)

Interaction of a Histidine-Rich Antimicrobial Saliva Peptide with Model Cell Membranes: The Role of Histidines

Author(s): Skog, A. E., Corucci, G., Tully, M. D., Fragneto, G., Gerelli, Y., Skepö, M.
Published in: Langmuir, Issue 39, 2023, Page(s) 7694, ISSN 1520-5827
Publisher: ACS Publications
DOI: 10.1021/acs.langmuir.3c00498

Temoneira-1 beta-lactamase is not a metalloenzyme, but its native metal ion binding sites allow for purification by immobilized metal ion affinity chromatography

Author(s): Nafaee, Z.H., Hunyadi-Gulyas, E., Gyurcsik, B.
Published in: Protein Expression and Purification, 2023, ISSN 1046-5928
Publisher: Academic Press
DOI: 10.1016/j.pep.2022.106169

Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex

Author(s): Ruedas, R., Vuillemot, R., Tubiana, T., Winter, J. M., Pieri, L., Arteni, A.-A., Samson, C., Jonic, S., Mathieu, M., Bressanelli, S.
Published in: Journal of Structural Biology, 2024, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2024.108095

The phosphodiesterase RmcA contributes to the adaptation of Pseudomonas putida to l-arginine

Author(s): Scribani-Rossi C, Molina-Henares MA, Angeli S, Cutruzzolà F, Paiardini A, Espinosa-Urgel M, Rinaldo S.
Published in: FEMS Microbiology Letters, Issue Volume 370, 2023, ISSN 1574-6968
Publisher: Oxford university press
DOI: 10.1093/femsle/fnad077

Electrochemical Kinetics Support a Second Coordination Sphere Mechanism in Metal-Based Formate Dehydrogenase

Author(s): Marta Meneghello, Alexandre Uzel, Marianne Broc, Rita R. Manuel, Axel Magalon, Christophe Léger, Inês A. C. Pereira, Anne Walburger, Vincent Fourmond
Published in: Angewandte Chemie - International edition, Issue 134, e202299999, 2022, ISSN 1521-3773
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anie.202212224

Visualizing Molecular Dynamics by High-Speed Atomic Force Microscopy

Author(s): van Ewijk, C., Maity, S., Roos, W.H.
Published in: Single Molecule Analysis . Methods in Molecular Biology, 2023, ISSN 1064-3745
Publisher: Humana Press, Inc.
DOI: 10.1007/978-1-0716-3377-9_17

Interactions and Insertion of Escherichia coli Hfq into Outer Membrane Vesicles as Revealed by Infrared and Orientated Circular Dichroism Spectroscopies

Author(s): Turbant, F., Waeytens, J., Blache, A., Esnouf, E., Raussens, V., Wegrzyn, G., Achouak, W., Wien, F., Arluison, V.
Published in: International Journal of Molecular Sciences, Issue 24(14), 11424, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241411424

Despite the odds: formation of the SARS-CoV-2 methylation complex

Author(s): Matsuda, A., Plewka, J., Rawski, M., Mourão, A., Zajko, W., Siebenmorgen, T., Kresik, L., Lis, K., Jones, A. N., Pachota, M., Karim, A., Hartman, K., Nirwal, S., Sonani, R., Chykunova,Y., Minia, I., Mak, P., Landthaler, M., Nowotny, M., Dubin, G., Sattler, M., Suder, P., Popowicz, G. M., Pyrć, K., Czarna, A.
Published in: Nucleic Acids Research, 2024, ISSN 1362-4962
Publisher: Oxford university press
DOI: 10.1093/nar/gkae165

Lateral membrane organization as target of an antimicrobial peptidomimetic compound

Author(s): Melcrova, A., Maity, S., Melcr, J., de Kok, N.A.W., Gabler, M., van der Eyden, J., Stensen, W., Svendsen, J.S.M., Driessen, A.J.M., Marrink, S.J., Roos, W.H.
Published in: Nature Communications, Issue 14(1) ar4038, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39726-5

Influence of the enzymatic treatment and pH on the interfacial and emulsifying properties of sunflower and olive protein hydrolysates

Author(s): Pérez-Gálvez, R., Maldonado-Valderrama, J., Jones, N. C., Hoffmann, S. V., Guadix, E., García-Moreno, P. J.
Published in: Food Hydrocolloids, Issue 154 ar110135, 2024, ISSN 0268-005X
Publisher: Elsevier BV
DOI: 10.1016/j.foodhyd.2024.110135

13th EBSA congress, July 24–28, 2021, Vienna, Austria

Author(s): 13th EBSA congress
Published in: European Biophysics Journal, Issue 50/S1, 2021, Page(s) 1-226, ISSN 0175-7571
Publisher: Springer Verlag
DOI: 10.1007/s00249-021-01558-w

ATR-FTIR Biosensors for Antibody Detection and Analysis

Author(s): Suys, O., Derenne, A., Goormaghtigh, E.
Published in: International Journal of Molecular Sciences, Issue 23(19), 2022, Page(s) 11895, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911895

Biochemical characterization of L-asparaginase isoforms from Rhizobium etli—the boosting effect of zinc

Author(s): Sliwiak, J., Worsztynowicz, P., Pokrywka, K., Loch, J. I., Grzechowiak, M., Jaskolski, M.
Published in: Frontiers in Chemistry, 2024, ISSN 2296-2646
Publisher: Frontiers Media S.A
DOI: 10.3389/fchem.2024.1373312

Protein Structural Denaturation Evaluated by MCR-ALS of Protein Microarray FTIR Spectra

Author(s): De Meutter, J., Goormaghtigh, E.
Published in: Analytical Chemistry, Issue 93(40), 2021, Page(s) 13441-13449, ISSN 1520-6882
Publisher: American Chemical Society publications
DOI: 10.1021/acs.analchem.1c01416

Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa

Author(s): Scribani Rossi, C., Eckartt, K., Scarchilli, E., Angeli, S., Price-Whelan, A., Di Matteo, A., Chevreuil, M., Raynal, B., Arcovito, A., Giacon, N., Fiorentino, F., Rotili, D.,
Published in: Microbiological Research, Issue Volume 277, 127498, 2023, ISSN 1618-0623
Publisher: Elsevier
DOI: 10.1016/j.micres.2023.127498

Synthesis of 3,4-Disubstituted Pyrroline Nitroxides Containing Diphenylphosphane or Diphenylphosphane Oxide Substituents

Author(s): Balázsi, A., Bognár, B., Jeko, J., Kálai, T.
Published in: SynOpen, 2024, ISSN 2509-9396
Publisher: Thieme
DOI: 10.1055/a-2264-8302

Raynals, an online tool for the analysis of dynamic light scattering.

Author(s): Burastero, O., Draper-Barr, G., Raynal, B., Chevreuil, M., England, P., Garcia-Alai, M.
Published in: Acta Crystallographica Section D, Issue 79, 2023, Page(s) p673–683, ISSN 2059-7983
Publisher: IUCr journals
DOI: 10.1107/s2059798323004862

Exploring the Metabolic Response of Pseudomonas putida to L-arginine

Author(s): Scribani-Rossi, C., Molina-Henares, M. A., Espinosa-Urgel, M., Rinaldo, S.
Published in: Advances in Experimental Medicine and Biology, 2024, ISSN 0065-2598
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/5584_2024_797

Limited high-throughput screening compatibility of the phenuivirus cap-binding domain

Author(s): Scherf, J., Vogel, D., Gul, S., Reinshagen, J., Gribbon, P., Rosenthal, M.
Published in: Scientific Reports, Issue 13, 2023, Page(s) 22820, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-50158-5

Guidelines for the Simulations of Nitroxide X-Band cw EPR Spectra from Site-Directed Spin Labeling Experiments Using SimLabel

Author(s): Etienne, E., Pierro, A., Tamburrini, K. C., Bonucci, A., Mileo, E., Martinho, M., Belle, V.
Published in: Molecules, Issue 28, 2023, Page(s) 1348, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28031348

Effect of Cholesterol on Biomimetic Membrane Curvature and Coronavirus Fusion Peptide Encapsulation

Author(s): Milogrodzka, I., Pham, D.T.N., Sama, G.R., Samadian, H., Zhai, J.L., de Campo, L., Kirby, N.M., Scott, T.F., Holl, M.M.B., van’t Hag, L.
Published in: ACS Nano, Issue 17 (9), 2023, Page(s) 8598-8612, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c01095

In-cell investigation of the conformational landscape of the GTPase UreG by SDSL-EPR

Author(s): Pierro, A., Tamburrini, K.C., Leguenno, H., Gerbaud, G., Etienne, E., Guigliarelli, B., Belle, V., Zambelli, B., Mileo, E.
Published in: iScience, Issue 26(10), 2023, Page(s) 107855, ISSN 2589-0042
Publisher: cell press
DOI: 10.1016/j.isci.2023.107855

Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane

Author(s): Sutinen, A., Jones, N. C., Hoffmann, S. V., Ruskamo, S., & Kursula, P.
Published in: Biophysical Chemistry, Issue 303, 107113, 2023, ISSN 0301-4622
Publisher: Elsevier BV
DOI: 10.1016/j.bpc.2023.107113

The Amyloid Assembly of the Bacterial Hfq Is Lipid-Driven and Lipid-Specific

Author(s): Turbant, F., Machiels, Q., Waeytens, J., Wien, F., Arluison, V.
Published in: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031434

Structural insights into the semiquinone form of human Cytochrome P450 reductase by DEER distance measurements between a native flavin and a spin labelled non-canonical amino acid

Author(s): Bizet, M., Byrne, D., Biaso, F., Gerbaud, G., Etienne, E., Briola, G., Guigliarelli, B., Urban, P., Dorlet, P., Kalai, T., Truan, G., Martinho, M.
Published in: Chemistry – A European Journal,, Issue 30 e202304307, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202304307

Pea and soy protein isolate fractal gels: the role of protein composition, structure and solubility on their gelation behaviour

Author(s): Tiong, A. Y. J., Crawford, S., Jones, N. C., McKinley, G., Batchelor, W., Hag, L. van ’t
Published in: Food Structure, 2024, ISSN 2213-3291
Publisher: Elsevier BV
DOI: 10.1016/j.foostr.2024.100374

Molecular dynamics simulations of the adsorption of an intrinsically disordered protein: Force field and water model evaluation in comparison with experiments

Author(s): Mona Koder Hamid, Linda K. Månsson, Viktoriia Meklesh, Per Persson and Marie Skepö
Published in: Frontiers in Molecular Biosciences, Issue 26 October 2022, 2022, ISSN 2296-889X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.958175

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability

Author(s): Sutinen, A., Paffenholz, D., Nguyen, G.T.T., Ruskamo, S., Torda, A.E., Kursula, P.
Published in: plos One, Issue 18(4) e0284532, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0284532

Chiroptical properties of membrane glycerophospholipids and their chiral backbones

Author(s): Bocková, J., Garcia, A. D., Jones, N. C., Hoffmann, S. V., Meinert, C.
Published in: Chirality, Issue 36(3), e23654, 2024, ISSN 0899-0042
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/chir.23654

Fluorescence labeling methods influence the aggregation process of α-syn in vitro differently

Author(s): Jadavi, S., Dante, S., Civiero, L., Sandre, M., Bubacco, L., Tosatto, L., Bianchini, P., Canale, C., Diaspro, A.
Published in: Nanoscale, Issue 15, 2023, Page(s) 8270, ISSN 2040-3372
Publisher: royal society of chemistry
DOI: 10.1039/d2nr05487f

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Author(s): Lavanya Moparthi, Viktor Sinica, Vamsi K. Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R. Filipovic, Viktorie Vlachova & Peter M. Zygmunt
Published in: Nature communications, Issue 13:6113, 17 October 2022, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33876-8

Antimicrobial Activity of an Fmoc-Plantaricin 149 Derivative Peptide against Multidrug-Resistant Bacteria.

Author(s): Righetto, G.M.; Lopes, J.L.d.S.; Bispo, P.J.M.; André, C.; Souza, J.M.; Andricopulo, A.D.; Beltramini, L.M.; Camargo, I.L.B.d.C.
Published in: Anitbiotics, Issue 12, 2023, Page(s) 391, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics12020391

Advantages of a synchrotron light source for fluorescence-detected linear dichroism

Author(s): Jones, N. C., Rodger, A., Hoffmann, S. V.
Published in: Chirality, Issue 36(4) e23667, 2024, ISSN 0899-0042
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/chir.23667

An allosteric redox switch involved in oxygen protection in a CO2 reductase

Author(s): Oliveira, A.R., Mota, C., Vilela-Alves, G., Manuel, R.R., Pedrosa, N., Fourmond, V., Klymanska, K., Léger, C., Guigliarelli, B., Romão, M.J., Pereira, I.A.C.
Published in: Nature Chemical Biology, Issue 20, 111-119, 2024, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-023-01484-2

Conference proceedings (8)

Thermodynamic landscape of the redox-centres in the electron-confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima

Author(s): Kilian Zuchan, Wolfgang Nitschke, Frauke Baymann, Nina Breuer, James Birell
Published in: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Issue Volume 1863, Supplement, 29, 2022, Page(s) 55, ISSN 0005-2728
Publisher: Elsevier
DOI: 10.1016/j.bbabio.2022.148757

MOSBRI- A New European Research Infrastructure for Molecular Biophysics

Author(s): Pierre Dorlet, Guillaume Gerbaud, Emilien Etienne, Stéphane Grimaldi, Bruno Guigliarelli, Valérie Belle.
Published in: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Issue Volume 1863, Supplement 29, 2022, Page(s) 28, ISSN 0005-2728
Publisher: Elsevier
DOI: 10.1016/j.bbabio.2022.148684

NAD(H)-induced flavosemiquinone stabilization in the electron-confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima

Author(s): Kilian Zuchan, Wolfgang Nitschke, Frauke Baymann, Nina Breuer, James Birell
Published in: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Issue Volume 1863, Supplement, 29, 2022, Page(s) 55, ISSN 0005-2728
Publisher: Elsevier
DOI: 10.1016/j.bbabio.2022.148758

TNA: Apply for access to laboratories of excellence in molecular scale biophysics research infrastructure (MOSBRI)

Author(s): Hoffmann, S., Jones, N., Raynal, B., Von Castelmur, E., Derbyshire, D., Sunnerhagen, M.
Published in: Acta Crystallographica A – Foundation and Advances, Issue 78 E350-E350, 2022, ISBN 9780190080112
Publisher: John Wiley & Sons
DOI: 10.1107/s2053273322093810

4th EBSA congress, July 31 – August 4, 2023, Stockholm, Sweden. Abstract: The MOlecular-Scale Biophysics Research Infrastructure (MOSBRI): a transnational initiative to structure and consolidate the European molecular biophysics community

Author(s): England, P.
Published in: European Biophysics Journal with Biophysical Letters, Issue 52 S178-S178, 2023
Publisher: Springer Nature
DOI: 10.1007/s00249-023-01668-7

Advanced in-house X-ray diffraction and scattering instruments as a service for structural biology

Author(s): Stransky, J., Pavlicek, J., Dohnalek, J.
Published in: 2023
Publisher: John Wiley & Sons
DOI: 10.1107/s2053273322093111

EPR-MRS site: EPR spectroscopy for the study of biomolecules

Author(s): Pierre Dorlet, Guillaume Gerbaud, Emilien Etienne, Stéphane Grimaldi, Bruno Guigliarelli, Valérie Belle
Published in: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Issue Volume 1863, Supplement 29, 2022, Page(s) 29, ISSN 0005-2728
Publisher: Elsevier
DOI: 10.1016/j.bbabio.2022.148685

Spectroscopic insights into the mechanism of anamox hydrazine synthase

Author(s): Wouter Versantvoort, Rainer Hienerwader, Christina Ferousi, Catherine Berthomieu, Laura van Niftrik, Frauke Baymann
Published in: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Issue Volume 1863, Supplement, 29, 2022, Page(s) 76, ISSN 0005-2728
Publisher: Elsevier
DOI: 10.1016/j.bbabio.2022.148818