MOlecular-Scale Biophysics Research Infrastructure

Información del proyecto

MOSBRI

Identificador del acuerdo de subvención: 101004806

DOI

10.3030/101004806

Fecha de la firma de la CE 16 Marzo 2021

Fecha de inicio 1 Julio 2021

Fecha de finalización 31 Octubre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Research Infrastructures

Coste total

€ 4 996 058,14

Aportación de la UE

€ 4 996 058,00

Coordinado por

INSTITUT PASTEUR
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (4)

Dissemination of novel methodologies via website

Dissemination of novel methodologies via websiteDeliverable to be submitted in M12 M24 and M48

Operational proposal system based on ARIA cloud service
Driving licence specifications and test materials at Operator level
MOSBRI website

Documents, reports (5)

Report on joint events organized with ARBRE and EBSA

Report on joint events organized with ARBRE and EBSADeliverable to be submitted in M18 M30 and M42

Analysis of the mapping of the needs for data standards/formats

Analysis of the mapping of the needs for data standardsformats

Established reference calibration samples
Analysis of the mapping of the needs for repository/database

Analysis of the mapping of the needs for repositorydatabase

Report on joint events organized with INSTRUCT

Report on joint events organized with INSTRUCTDeliverable to be submitted in M18 M30 and M42

Other (1)

Setting-up of a TNA moderator panel and of a TNA reviewer panel

Publicaciones

Peer reviewed articles (34)

Interaction of a Histidine-Rich Antimicrobial Saliva Peptide with Model Cell Membranes: The Role of Histidines

Autores: Skog, A. E., Corucci, G., Tully, M. D., Fragneto, G., Gerelli, Y., Skepö, M.
Publicado en: Langmuir, Edición 39, 2023, Página(s) 7694, ISSN 1520-5827
Editor: ACS Publications
DOI: 10.1021/acs.langmuir.3c00498

Temoneira-1 beta-lactamase is not a metalloenzyme, but its native metal ion binding sites allow for purification by immobilized metal ion affinity chromatography

Autores: Nafaee, Z.H., Hunyadi-Gulyas, E., Gyurcsik, B.
Publicado en: Protein Expression and Purification, 2023, ISSN 1046-5928
Editor: Academic Press
DOI: 10.1016/j.pep.2022.106169

Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex

Autores: Ruedas, R., Vuillemot, R., Tubiana, T., Winter, J. M., Pieri, L., Arteni, A.-A., Samson, C., Jonic, S., Mathieu, M., Bressanelli, S.
Publicado en: Journal of Structural Biology, 2024, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2024.108095

The phosphodiesterase RmcA contributes to the adaptation of Pseudomonas putida to l-arginine

Autores: Scribani-Rossi C, Molina-Henares MA, Angeli S, Cutruzzolà F, Paiardini A, Espinosa-Urgel M, Rinaldo S.
Publicado en: FEMS Microbiology Letters, Edición Volume 370, 2023, ISSN 1574-6968
Editor: Oxford university press
DOI: 10.1093/femsle/fnad077

Electrochemical Kinetics Support a Second Coordination Sphere Mechanism in Metal-Based Formate Dehydrogenase

Autores: Marta Meneghello, Alexandre Uzel, Marianne Broc, Rita R. Manuel, Axel Magalon, Christophe Léger, Inês A. C. Pereira, Anne Walburger, Vincent Fourmond
Publicado en: Angewandte Chemie - International edition, Edición 134, e202299999, 2022, ISSN 1521-3773
Editor: Wiley-VCH GmbH
DOI: 10.1002/anie.202212224

Visualizing Molecular Dynamics by High-Speed Atomic Force Microscopy

Autores: van Ewijk, C., Maity, S., Roos, W.H.
Publicado en: Single Molecule Analysis . Methods in Molecular Biology, 2023, ISSN 1064-3745
Editor: Humana Press, Inc.
DOI: 10.1007/978-1-0716-3377-9_17

Interactions and Insertion of Escherichia coli Hfq into Outer Membrane Vesicles as Revealed by Infrared and Orientated Circular Dichroism Spectroscopies

Autores: Turbant, F., Waeytens, J., Blache, A., Esnouf, E., Raussens, V., Wegrzyn, G., Achouak, W., Wien, F., Arluison, V.
Publicado en: International Journal of Molecular Sciences, Edición 24(14), 11424, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241411424

Despite the odds: formation of the SARS-CoV-2 methylation complex

Autores: Matsuda, A., Plewka, J., Rawski, M., Mourão, A., Zajko, W., Siebenmorgen, T., Kresik, L., Lis, K., Jones, A. N., Pachota, M., Karim, A., Hartman, K., Nirwal, S., Sonani, R., Chykunova,Y., Minia, I., Mak, P., Landthaler, M., Nowotny, M., Dubin, G., Sattler, M., Suder, P., Popowicz, G. M., Pyrć, K., Czarna, A.
Publicado en: Nucleic Acids Research, 2024, ISSN 1362-4962
Editor: Oxford university press
DOI: 10.1093/nar/gkae165

Lateral membrane organization as target of an antimicrobial peptidomimetic compound

Autores: Melcrova, A., Maity, S., Melcr, J., de Kok, N.A.W., Gabler, M., van der Eyden, J., Stensen, W., Svendsen, J.S.M., Driessen, A.J.M., Marrink, S.J., Roos, W.H.
Publicado en: Nature Communications, Edición 14(1) ar4038, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-39726-5

Influence of the enzymatic treatment and pH on the interfacial and emulsifying properties of sunflower and olive protein hydrolysates

Autores: Pérez-Gálvez, R., Maldonado-Valderrama, J., Jones, N. C., Hoffmann, S. V., Guadix, E., García-Moreno, P. J.
Publicado en: Food Hydrocolloids, Edición 154 ar110135, 2024, ISSN 0268-005X
Editor: Elsevier BV
DOI: 10.1016/j.foodhyd.2024.110135

13th EBSA congress, July 24–28, 2021, Vienna, Austria

Autores: 13th EBSA congress
Publicado en: European Biophysics Journal, Edición 50/S1, 2021, Página(s) 1-226, ISSN 0175-7571
Editor: Springer Verlag
DOI: 10.1007/s00249-021-01558-w

ATR-FTIR Biosensors for Antibody Detection and Analysis

Autores: Suys, O., Derenne, A., Goormaghtigh, E.
Publicado en: International Journal of Molecular Sciences, Edición 23(19), 2022, Página(s) 11895, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911895

Biochemical characterization of L-asparaginase isoforms from Rhizobium etli—the boosting effect of zinc

Autores: Sliwiak, J., Worsztynowicz, P., Pokrywka, K., Loch, J. I., Grzechowiak, M., Jaskolski, M.
Publicado en: Frontiers in Chemistry, 2024, ISSN 2296-2646
Editor: Frontiers Media S.A
DOI: 10.3389/fchem.2024.1373312

Protein Structural Denaturation Evaluated by MCR-ALS of Protein Microarray FTIR Spectra

Autores: De Meutter, J., Goormaghtigh, E.
Publicado en: Analytical Chemistry, Edición 93(40), 2021, Página(s) 13441-13449, ISSN 1520-6882
Editor: American Chemical Society publications
DOI: 10.1021/acs.analchem.1c01416

Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa

Autores: Scribani Rossi, C., Eckartt, K., Scarchilli, E., Angeli, S., Price-Whelan, A., Di Matteo, A., Chevreuil, M., Raynal, B., Arcovito, A., Giacon, N., Fiorentino, F., Rotili, D.,
Publicado en: Microbiological Research, Edición Volume 277, 127498, 2023, ISSN 1618-0623
Editor: Elsevier
DOI: 10.1016/j.micres.2023.127498

Synthesis of 3,4-Disubstituted Pyrroline Nitroxides Containing Diphenylphosphane or Diphenylphosphane Oxide Substituents

Autores: Balázsi, A., Bognár, B., Jeko, J., Kálai, T.
Publicado en: SynOpen, 2024, ISSN 2509-9396
Editor: Thieme
DOI: 10.1055/a-2264-8302

Raynals, an online tool for the analysis of dynamic light scattering.

Autores: Burastero, O., Draper-Barr, G., Raynal, B., Chevreuil, M., England, P., Garcia-Alai, M.
Publicado en: Acta Crystallographica Section D, Edición 79, 2023, Página(s) p673–683, ISSN 2059-7983
Editor: IUCr journals
DOI: 10.1107/s2059798323004862

Exploring the Metabolic Response of Pseudomonas putida to L-arginine

Autores: Scribani-Rossi, C., Molina-Henares, M. A., Espinosa-Urgel, M., Rinaldo, S.
Publicado en: Advances in Experimental Medicine and Biology, 2024, ISSN 0065-2598
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/5584_2024_797

Limited high-throughput screening compatibility of the phenuivirus cap-binding domain

Autores: Scherf, J., Vogel, D., Gul, S., Reinshagen, J., Gribbon, P., Rosenthal, M.
Publicado en: Scientific Reports, Edición 13, 2023, Página(s) 22820, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-50158-5

Guidelines for the Simulations of Nitroxide X-Band cw EPR Spectra from Site-Directed Spin Labeling Experiments Using SimLabel

Autores: Etienne, E., Pierro, A., Tamburrini, K. C., Bonucci, A., Mileo, E., Martinho, M., Belle, V.
Publicado en: Molecules, Edición 28, 2023, Página(s) 1348, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28031348

Effect of Cholesterol on Biomimetic Membrane Curvature and Coronavirus Fusion Peptide Encapsulation

Autores: Milogrodzka, I., Pham, D.T.N., Sama, G.R., Samadian, H., Zhai, J.L., de Campo, L., Kirby, N.M., Scott, T.F., Holl, M.M.B., van’t Hag, L.
Publicado en: ACS Nano, Edición 17 (9), 2023, Página(s) 8598-8612, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.3c01095

In-cell investigation of the conformational landscape of the GTPase UreG by SDSL-EPR

Autores: Pierro, A., Tamburrini, K.C., Leguenno, H., Gerbaud, G., Etienne, E., Guigliarelli, B., Belle, V., Zambelli, B., Mileo, E.
Publicado en: iScience, Edición 26(10), 2023, Página(s) 107855, ISSN 2589-0042
Editor: cell press
DOI: 10.1016/j.isci.2023.107855

Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane

Autores: Sutinen, A., Jones, N. C., Hoffmann, S. V., Ruskamo, S., & Kursula, P.
Publicado en: Biophysical Chemistry, Edición 303, 107113, 2023, ISSN 0301-4622
Editor: Elsevier BV
DOI: 10.1016/j.bpc.2023.107113

The Amyloid Assembly of the Bacterial Hfq Is Lipid-Driven and Lipid-Specific

Autores: Turbant, F., Machiels, Q., Waeytens, J., Wien, F., Arluison, V.
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031434

Structural insights into the semiquinone form of human Cytochrome P450 reductase by DEER distance measurements between a native flavin and a spin labelled non-canonical amino acid

Autores: Bizet, M., Byrne, D., Biaso, F., Gerbaud, G., Etienne, E., Briola, G., Guigliarelli, B., Urban, P., Dorlet, P., Kalai, T., Truan, G., Martinho, M.
Publicado en: Chemistry – A European Journal,, Edición 30 e202304307, 2024, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202304307

Pea and soy protein isolate fractal gels: the role of protein composition, structure and solubility on their gelation behaviour

Autores: Tiong, A. Y. J., Crawford, S., Jones, N. C., McKinley, G., Batchelor, W., Hag, L. van ’t
Publicado en: Food Structure, 2024, ISSN 2213-3291
Editor: Elsevier BV
DOI: 10.1016/j.foostr.2024.100374

Molecular dynamics simulations of the adsorption of an intrinsically disordered protein: Force field and water model evaluation in comparison with experiments

Autores: Mona Koder Hamid, Linda K. Månsson, Viktoriia Meklesh, Per Persson and Marie Skepö
Publicado en: Frontiers in Molecular Biosciences, Edición 26 October 2022, 2022, ISSN 2296-889X
Editor: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.958175

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability

Autores: Sutinen, A., Paffenholz, D., Nguyen, G.T.T., Ruskamo, S., Torda, A.E., Kursula, P.
Publicado en: plos One, Edición 18(4) e0284532, 2023, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0284532

Chiroptical properties of membrane glycerophospholipids and their chiral backbones

Autores: Bocková, J., Garcia, A. D., Jones, N. C., Hoffmann, S. V., Meinert, C.
Publicado en: Chirality, Edición 36(3), e23654, 2024, ISSN 0899-0042
Editor: John Wiley & Sons Inc.
DOI: 10.1002/chir.23654

Fluorescence labeling methods influence the aggregation process of α-syn in vitro differently

Autores: Jadavi, S., Dante, S., Civiero, L., Sandre, M., Bubacco, L., Tosatto, L., Bianchini, P., Canale, C., Diaspro, A.
Publicado en: Nanoscale, Edición 15, 2023, Página(s) 8270, ISSN 2040-3372
Editor: royal society of chemistry
DOI: 10.1039/d2nr05487f

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Autores: Lavanya Moparthi, Viktor Sinica, Vamsi K. Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R. Filipovic, Viktorie Vlachova & Peter M. Zygmunt
Publicado en: Nature communications, Edición 13:6113, 17 October 2022, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-33876-8

Antimicrobial Activity of an Fmoc-Plantaricin 149 Derivative Peptide against Multidrug-Resistant Bacteria.

Autores: Righetto, G.M.; Lopes, J.L.d.S.; Bispo, P.J.M.; André, C.; Souza, J.M.; Andricopulo, A.D.; Beltramini, L.M.; Camargo, I.L.B.d.C.
Publicado en: Anitbiotics, Edición 12, 2023, Página(s) 391, ISSN 2079-6382
Editor: MDPI
DOI: 10.3390/antibiotics12020391

Advantages of a synchrotron light source for fluorescence-detected linear dichroism

Autores: Jones, N. C., Rodger, A., Hoffmann, S. V.
Publicado en: Chirality, Edición 36(4) e23667, 2024, ISSN 0899-0042
Editor: John Wiley & Sons Inc.
DOI: 10.1002/chir.23667

An allosteric redox switch involved in oxygen protection in a CO2 reductase

Autores: Oliveira, A.R., Mota, C., Vilela-Alves, G., Manuel, R.R., Pedrosa, N., Fourmond, V., Klymanska, K., Léger, C., Guigliarelli, B., Romão, M.J., Pereira, I.A.C.
Publicado en: Nature Chemical Biology, Edición 20, 111-119, 2024, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41589-023-01484-2

Conference proceedings (8)

Thermodynamic landscape of the redox-centres in the electron-confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima

Autores: Kilian Zuchan, Wolfgang Nitschke, Frauke Baymann, Nina Breuer, James Birell
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición Volume 1863, Supplement, 29, 2022, Página(s) 55, ISSN 0005-2728
Editor: Elsevier
DOI: 10.1016/j.bbabio.2022.148757

MOSBRI- A New European Research Infrastructure for Molecular Biophysics

Autores: Pierre Dorlet, Guillaume Gerbaud, Emilien Etienne, Stéphane Grimaldi, Bruno Guigliarelli, Valérie Belle.
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición Volume 1863, Supplement 29, 2022, Página(s) 28, ISSN 0005-2728
Editor: Elsevier
DOI: 10.1016/j.bbabio.2022.148684

NAD(H)-induced flavosemiquinone stabilization in the electron-confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima

Autores: Kilian Zuchan, Wolfgang Nitschke, Frauke Baymann, Nina Breuer, James Birell
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición Volume 1863, Supplement, 29, 2022, Página(s) 55, ISSN 0005-2728
Editor: Elsevier
DOI: 10.1016/j.bbabio.2022.148758

TNA: Apply for access to laboratories of excellence in molecular scale biophysics research infrastructure (MOSBRI)

Autores: Hoffmann, S., Jones, N., Raynal, B., Von Castelmur, E., Derbyshire, D., Sunnerhagen, M.
Publicado en: Acta Crystallographica A – Foundation and Advances, Edición 78 E350-E350, 2022, ISBN 9780190080112
Editor: John Wiley & Sons
DOI: 10.1107/s2053273322093810

4th EBSA congress, July 31 – August 4, 2023, Stockholm, Sweden. Abstract: The MOlecular-Scale Biophysics Research Infrastructure (MOSBRI): a transnational initiative to structure and consolidate the European molecular biophysics community

Autores: England, P.
Publicado en: European Biophysics Journal with Biophysical Letters, Edición 52 S178-S178, 2023
Editor: Springer Nature
DOI: 10.1007/s00249-023-01668-7

Advanced in-house X-ray diffraction and scattering instruments as a service for structural biology

Autores: Stransky, J., Pavlicek, J., Dohnalek, J.
Publicado en: 2023
Editor: John Wiley & Sons
DOI: 10.1107/s2053273322093111

EPR-MRS site: EPR spectroscopy for the study of biomolecules

Autores: Pierre Dorlet, Guillaume Gerbaud, Emilien Etienne, Stéphane Grimaldi, Bruno Guigliarelli, Valérie Belle
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición Volume 1863, Supplement 29, 2022, Página(s) 29, ISSN 0005-2728
Editor: Elsevier
DOI: 10.1016/j.bbabio.2022.148685

Spectroscopic insights into the mechanism of anamox hydrazine synthase

Autores: Wouter Versantvoort, Rainer Hienerwader, Christina Ferousi, Catherine Berthomieu, Laura van Niftrik, Frauke Baymann
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición Volume 1863, Supplement, 29, 2022, Página(s) 76, ISSN 0005-2728
Editor: Elsevier
DOI: 10.1016/j.bbabio.2022.148818